Výsledky vyhledávání - "Allan F. Mock"

Akademický článek

Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development

Autor: Fadi A. Issa, Allan F. Mock, Alvaro Sagasti, Diane M. Papazian

Publikováno v: Disease Models & Mechanisms, Vol 5, Iss 6, Pp 921-929 (2012)

SUMMARY Spinocerebellar ataxia type 13 (SCA13) is an autosomal dominant disease caused by mutations in the Kv3.3 voltage-gated potassium (K+) channel. SCA13 exists in two forms: infant onset is characterized by severe cerebellar atrophy, persistent m

Externí odkaz: https://doaj.org/article/c69954009fee4873b0c6763005ee4637

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R1 in the Shaker S4 occupies the gating charge transfer center in the resting state

Autor: Meng-chin A. Lin, Allan F. Mock, Jui-Yi Hsieh, Diane M. Papazian

Publikováno v: The Journal of General Physiology

During voltage-dependent activation in Shaker channels, four arginine residues in the S4 segment (R1-R4) cross the transmembrane electric field. It has been proposed that R1-R4 movement is facilitated by a "gating charge transfer center" comprising a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598319d0a6fc12500a84ef918eb5990d
https://doi.org/10.1085/jgp.201110642

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Spinocerebellar Ataxia Type 13 Mutant Potassium Channel Alters Neuronal Excitability and Causes Locomotor Deficits in Zebrafish

Autor: Christopher Mazzochi, Allan F. Mock, Fadi A. Issa, Diane M. Papazian

Publikováno v: The Journal of Neuroscience. 31:6831-6841

Whether changes in neuronal excitability can cause neurodegenerative disease in the absence of other factors such as protein aggregation is unknown. Mutations in the Kv3.3 voltage-gated K+channel cause spinocerebellar ataxia type 13 (SCA13), a human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3de767a5a3d9825b0151e5a70c01a5a
https://doi.org/10.1523/jneurosci.6572-10.2011

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Atomic Proximity between S4 Segment and Pore Domain in Shaker Potassium Channels

Autor: Muriel Laine, Benoît Roux, Meng-chin A. Lin, Diane M. Papazian, Allan F. Mock, John P. Bannister, William R. Silverman

Publikováno v: Neuron. 39(3):467-481

A recently proposed model for voltage-dependent activation in K+ channels, largely influenced by the KvAP X-ray structure, suggests that S4 is located at the periphery of the channel and moves through the lipid bilayer upon depolarization. To investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398c3da0afa5d06f4776af75a56ab27a

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Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio)

Autor: Yali Zhao, Nancy L. Wayne, Meng-chin A. Lin, Allan F. Mock, Ming Yang

Publikováno v: Zhao, Y; Lin, MCA; Mock, A; Yang, M; & Wayne, NL. (2014). Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). PLoS ONE, 9(8). doi: 10.1371/journal.pone.0104330. UCLA: Retrieved from: http://www.escholarship.org/uc/item/65b49223
PloS one, vol 9, iss 8
PLoS ONE, Vol 9, Iss 8, p e104330 (2014)
PLoS ONE

Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals. Inactivating mutations in Kiss1 and the kisspeptin receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba114897fb3c5f08cebe7f58472cbd4e
http://www.escholarship.org/uc/item/65b49223

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Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits

Autor: Allan F. Mock, Christine T. Schulteis, Seema K. Tiwari-Woodruff, Diane M. Papazian

Publikováno v: Biophysical Journal. 72(4):1489-1500

In voltage-dependent Shaker K+ channels, charged residues E293 in transmembrane segment S2 and R365, R368, and R371 in S4 contribute significantly to the gating charge movement that accompanies activation. Using an intragenic suppression strategy, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b47cad2114df6fb7418132fbde2420e

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Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development

Autor: Alvaro Sagasti, Allan F. Mock, Fadi A. Issa, Diane M. Papazian

Publikováno v: Disease Models & Mechanisms, Vol 5, Iss 6, Pp 921-929 (2012)
Disease Models & Mechanisms

Summary Spinocerebellar ataxia type 13 (SCA13) is an autosomal dominant disease caused by mutations in the Kv3.3 voltage-gated potassium (K+) channel. SCA13 exists in two forms: infant onset is characterized by severe cerebellar atrophy, persistent m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f2123b0752c7e4ebb3ee86fefa0dde
https://doi.org/10.1242/dmm.010157

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Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes

Autor: Diane M. Papazian, Ngatali A. Minassian, Alexandra Durr, Stefan M. Pulst, Virgilio Gerald H. Evidente, Allan F. Mock, Michael F. Waters, John P. Bannister, Giovanni Stevanin, Dominic B. Fee, Alexis Brice, Karla P. Figueroa, Dagmar Nolte, Ulrich Müller

Publikováno v: Nature genetics. 38(4)

Potassium channel mutations have been described in episodic neurological diseases. We report that K+ channel mutations cause disease phenotypes with neurodevelopmental and neurodegenerative features. In a Filipino adult-onset ataxia pedigree, the cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3370f48c66a72b0f065d9b3aaa0ace19
https://pubmed.ncbi.nlm.nih.gov/16501573

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Mg(2+) modulates voltage-dependent activation in ether-à-go-go potassium channels by binding between transmembrane segments S2 and S3

Autor: Allan F. Mock, Chih Yung Tang, Diane M. Papazian, William R. Silverman, Kyung-Bong Huh

Publikováno v: The Journal of General Physiology

Extracellular Mg(2+) directly modulates voltage-dependent activation in ether-à-go-go (eag) potassium channels, slowing the kinetics of ionic and gating currents (Tang, C.-Y., F. Bezanilla, and D.M. Papazian. 2000. J. Gen. Physiol. 115:319-337). To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38526cbbd28d01412a27e87cdaf7208b
https://pubmed.ncbi.nlm.nih.gov/11055995

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Electrostatic interactions of S4 voltage sensor in Shaker K+ channel

Autor: Yu Huang, Diane M. Papazian, Allan F. Mock, Daniel H Wainstock, Sang-Ah Seoh, Xuesi M. Shao

Publikováno v: Neuron. 14(6)

The S4 segment comprises part of the voltage sensor in Shaker K + channels. We have used a strategy similar to intragenic suppression, but without a genetic selection, to identify electrostatic interactions of the S4 segment that may be important in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7754df7c1ef324200adf176b532eeeec
https://pubmed.ncbi.nlm.nih.gov/7605638

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