Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Allan Doctor"'
Autor:
Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Katherine Sward, J. Michael Dean, H. J. Park, Joseph A. Carcillo
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to obtain rationale for
Externí odkaz:
https://doaj.org/article/dc1f2d5909cd4b9fa2e610b7b3a2910d
Autor:
Stephen C. Rogers, Mary Brummet, Zohreh Safari, Qihong Wang, Tobi Rowden, Tori Boyer, Allan Doctor
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Introduction: Coronavirus disease 2019 (COVID-19) is characterized by impaired oxygen (O2) homeostasis, including O2 sensing, uptake, transport/delivery, and consumption. Red blood cells (RBCs) are central to maintaining O2 homeostasis and undergo di
Externí odkaz:
https://doaj.org/article/29b8feb7ee5b44c1ab1ab62de65bdc89
Autor:
Saini Setua, Kiruphagaran Thangaraju, Monika Dzieciatkowska, Rebecca B. Wilkerson, Travis Nemkov, Derek R. Lamb, Yutaka Tagaya, Tori Boyer, Tobi Rowden, Allan Doctor, Angelo D’Alessandro, Paul W. Buehler
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Extracellular vesicles (EVs) participate in cell-to-cell communication and contribute toward homeostasis under physiological conditions. But EVs can also contribute toward a wide array of pathophysiology like cancer, sepsis, sickle cell dise
Externí odkaz:
https://doaj.org/article/9109a47715684d99bb8b3708551337b1
Autor:
Gurneet S. Sangha, Callie M. Weber, Ryan M. Sapp, Saini Setua, Kiruphagaran Thangaraju, Morgan Pettebone, Stephen C. Rogers, Allan Doctor, Paul W. Buehler, Alisa M. Clyne
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Generating physiologically relevant red blood cell extracellular vesicles (RBC-EVs) for mechanistic studies is challenging. Herein, we investigated how to generate and isolate high concentrations of RBC-EVs in vitro via shear stress and
Externí odkaz:
https://doaj.org/article/ee4b96be5fa1485fbb67ad70e659724a
Autor:
Yidi Qin, Kate F. Kernan, Zhenjiang Fan, Hyun-Jung Park, Soyeon Kim, Scott W. Canna, John A. Kellum, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Russell Banks, Ron W. Reeder, Richard Holubkov, Daniel A. Notterman, J. Michael Dean, Joseph A. Carcillo
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-16 (2022)
Abstract Background Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that are often missed or have delay
Externí odkaz:
https://doaj.org/article/97816617627644b9825463ea1be360f3
Autor:
Fiona Muttalib, Ellis Ballard, Josephine Langton, Sara Malone, Yudy Fonseca, Andreas Hansmann, Kenneth Remy, Peter Hovmand, Allan Doctor
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Group model building (GMB) is a method to facilitate shared understanding of structures and relationships that determine system behaviors. This project aimed to determine the feasibility of GMB in a resource-limited setting and to
Externí odkaz:
https://doaj.org/article/d501fce7387d491bb5a437e3bca5c03a
Autor:
Katherine M. Steffen, Philip C. Spinella, Laura M. Holdsworth, Mackenzie A. Ford, Grace M. Lee, Steven M. Asch, Enola K. Proctor, Allan Doctor
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Purpose: Risks of red blood cell transfusion may outweigh benefits for many patients in Pediatric Intensive Care Units (PICUs). The Transfusion and Anemia eXpertise Initiative (TAXI) recommendations seek to limit unnecessary and potentially harmful t
Externí odkaz:
https://doaj.org/article/aad62c9a35b54124bb4768a0ef37935f
Autor:
John C. Lin, Lauren M. Barron, Adam M. Vogel, Ryan M. Colvin, Sirine A. Baltagi, Allan Doctor, Avihu Z. Gazit, Mary Mehegan, Nicole O'Connor, Ahmed S. Said, Mark Shepard, Michael Wallendorf, Philip C. Spinella
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Purpose: We sought to determine the impact of a comprehensive, context-responsive anticoagulation and transfusion guideline on bleeding and thrombotic complication rates and blood product utilization during extracorporeal membrane oxygenation (ECMO).
Externí odkaz:
https://doaj.org/article/d4b4919559914d5a847c720ba11d63df
Autor:
Aaron Issaian, Ariel Hay, Monika Dzieciatkowska, Domenico Roberti, Silverio Perrotta, Zsuzsanna Darula, Jasmina Redzic, Micheal P. Busch, Grier P. Page, Stephen C. Rogers, Allan Doctor, Kirk C. Hansen, Elan Z. Eisenmesser, James C. Zimring, Angelo D’Alessandro
Publikováno v:
Haematologica, Vol 106, Iss 11 (2021)
Band 3 (anion exchanger 1; AE1) is the most abundant membrane protein in red blood cells, which in turn are the most abundant cells in the human body. A compelling model posits that, at high oxygen saturation, the N-terminal cytosolic domain of AE1 b
Externí odkaz:
https://doaj.org/article/62266c7a47f34d6da98e2ad9ab1f4975
Autor:
Andrea H. Gillespie, Allan Doctor
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Red Blood Cells (RBCs) have been increasingly recognized to play important roles in hemostasis and the mechanisms by which they do so continue to be elucidated. First and foremost, RBC biomechanics are the principal determinant of viscosity and flow
Externí odkaz:
https://doaj.org/article/df9f5718de4e4605be20101a90244375