Zobrazeno 1 - 10
of 628
pro vyhledávání: '"Allan D Struthers"'
Autor:
Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D Struthers, Alan G Begg, Li Wei, Anthony J Avery, Jaspal S Taggar, Andrew Walker, Suzanne L Duce, Rebecca J Barr, Jennifer S Dumbleton, Evelien D Rooke, Jonathan N Townend, Lewis D Ritchie, Thomas M MacDonald
Publikováno v:
Health Technology Assessment, Vol 28, Iss 18 (2024)
Abstract Background Allopurinol is a xanthine oxidase inhibitor that lowers serum uric acid and is used to prevent acute gout flares in patients with gout. Observational and small interventional studies have suggested beneficial cardiovascular effect
Externí odkaz:
https://doaj.org/article/fe11fb9eb1a34d309ffcfa360082b971
Autor:
Alvin Shrestha, Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M Band, Louise A Burton, Vera Cvoro, Peter T Donnan, Gordon W Duncan, Jacob George, Adam L Gordon, Celia L Gregson, Adrian Hapca, Cheryl Hume, Thomas A Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C Roberts, Avan A Sayer, Christos Rossios, Karen T Smith, Roy L Soiza, Claire J Steves, Allan D Struthers, Divya Tiwari, Julie Whitney, Miles D Witham, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0307268 (2024)
IntroductionUnderstanding genetic contributors to sarcopenia (age-related loss of muscle strength and mass) is key to finding effective therapies. Variants of the bradykinin receptor 2 (BDKRB2) have been linked to athletic and muscle performance. The
Externí odkaz:
https://doaj.org/article/729f9642b39144fe86a84ce912c50d84
Autor:
Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M Band, Louise A Burton, Vera Cvoro, Peter T Donnan, Gordon W Duncan, Jacob George, Adam L Gordon, Celia L Gregson, Adrian Hapca, Cheryl Hume, Thomas A Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C Roberts, Christos Rossios, Avan A Sayer, Karen T Smith, Roy L Soiza, Claire J Steves, Allan D Struthers, Divya Tiwari, Julie Whitney, Miles D Witham, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294330 (2023)
BackgroundAgeing is associated with changes in body composition including an overall reduction in muscle mass and a proportionate increase in fat mass. Sarcopenia is characterised by losses in both muscle mass and strength. Body composition and muscl
Externí odkaz:
https://doaj.org/article/c30fb2aff4ea4c5a9943bf38e3bcd800
Autor:
Christos Rossios, Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M Band, Louise A Burton, Vera Cvoro, Peter T Donnan, Gordon W Duncan, Jacob George, Adam L Gordon, Celia L Gregson, Adrian Hapca, Cheryl Hume, Thomas A Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C Roberts, Avan A Sayer, Karen T Smith, Roy L Soiza, Claire J Steves, Allan D Struthers, Divya Tiwari, Julie Whitney, Miles D Witham, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292402 (2023)
BackgroundAngiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial was designed t
Externí odkaz:
https://doaj.org/article/8651c39bcec645eeb9cc2a0bb488cd15
Autor:
Miles D Witham, Simon Adamson, Alison Avenell, Margaret M Band, Tufail Bashir, Peter T Donnan, Jacob George, Adrian Hapca, Cheryl Hume, Paul Kemp, Emma McKenzie, Kristina Pilvinyte, Christos Rossios, Karen Smith, Allan D Struthers, Deepa Sumukadas
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 9, Iss 8 (2022)
Background: Angiotensin-converting enzyme inhibitors and leucine are promising potential treatments for sarcopenia. Neither has yet been tested in adequately powered randomised trials in patients with sarcopenia. Objectives: To determine the efficacy
Externí odkaz:
https://doaj.org/article/6cbf95e5be004745bf2b2a08f3047014
Autor:
Jonathan R Weir-McCall, Faisel Khan, Matthew A Lambert, Carly L Adamson, Michael Gardner, Stephen J Gandy, Prasad Guntur Ramkumar, Jill J F Belch, Allan D Struthers, Petra Rauchhaus, Andrew D Morris, J Graeme Houston
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99190 (2014)
Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic bur
Externí odkaz:
https://doaj.org/article/7d61aa1063714777972bf91a175cdab5
Autor:
Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D Struthers, Alan G Begg, Li Wei, Anthony J Avery, Jaspal S Taggar, Andrew Walker, Suzanne L Duce, Rebecca J Barr, Jennifer S Dumbleton, Evelien D Rooke, Jonathan N Townend, Lewis D Ritchie, Thomas M MacDonald, Husnat Ahmed, Peter Arthur, Jane Aziz, Lawrence Barnes, Sarah Boyle, Tom Brighton, Morris Brown, Mark Caulfield, Jesse Dawson, Martin Denvir, Alexander SF Doney, Sagar Doshi, Moira Dryburgh, Michael Eddleston, Jim Finlayson, Ahmet Fuat, Jacqueline Furnace, JW Kerr Grieve, Greg Guthrie, Sharon Ham, Emma Isaard, Claudine Jennings, Richard Johnson, Claire Kerr, Sohail Khan, Kailash Krishnan, Susan Long, Anne Mackintosh, Mary Joan Macleod, Terry McCormack, Paul McEleny, Monique Morar, Adnan Nadir, David Newby, Colin Petrie, David Preiss, Stuart Ralston, Marc Randall, Helen Routledge, Saad Shakir, Raj Sharma, Bridget Shepherd, Don Sims, Gordon Snedden, Jasper Trevelyan, Christopher Weir, Robin Weir, Kirsty Wetherall, Robbie Wilson, Adam Wilson, Kris Zutis
Publikováno v:
Lancet (London, England). 400(10359)
Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed to determine whether allopurinol therapy impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb79695443ce89635b502ddd2ccf20f
https://pubmed.ncbi.nlm.nih.gov/36215992
https://pubmed.ncbi.nlm.nih.gov/36215992
Autor:
Deepa Sumukadas, S. Richard Nicholas, Clare Clarke, Miles D. Witham, Anita Hutcheon, Christopher Gingles, Jacob George, Allan D. Struthers, Lukasz Priba, Ian Cavin, Rebecca R. Chungath, Stephen J. Gandy
Publikováno v:
JCSM Clinical Reports. 6:71-79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b9025dc24dd21834c49cfa3ef46673c
https://doi.org/10.1002/crt2.33
https://doi.org/10.1002/crt2.33
Autor:
Alan G. Jardine, Allan D. Struthers, J. Graeme Houston, Rosemary Woodward, Elaine Rutherford, Graham A. Stewart, Sheila Ireland, Stephen J. Gandy, Petra Rauchhaus, Miles D. Witham, Kenneth Mangion, Giles Roditi, Patrick B. Mark, Mark S. MacGregor
Publikováno v:
Kidney International Reports
Introduction Increased left ventricular mass index (LVMI) is associated with mortality in end-stage renal disease. LVMI regression may improve outcomes. Allopurinol has reduced LVMI in randomized controlled trials in chronic kidney disease, diabetes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f20e2ecb88a9aeeb79fb0c90052ac78
http://europepmc.org/articles/PMC7783562
http://europepmc.org/articles/PMC7783562
Autor:
Rory J. McCrimmon, Ify R. Mordi, Allan D. Struthers, Jagdeep Singh, Natalie A. Mordi, Chim C. Lang
Publikováno v:
Circulation
Supplemental Digital Content is available in the text.
Background: SGLT2 (sodium-glucose cotransporter-2) inhibitors improve heart failure–associated outcomes in patients with type 2 diabetes. In patients with heart failure, SGLT2 inhibitors w
Background: SGLT2 (sodium-glucose cotransporter-2) inhibitors improve heart failure–associated outcomes in patients with type 2 diabetes. In patients with heart failure, SGLT2 inhibitors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4810d6ea1dc4b88601ffdbd78b79bc21
https://doi.org/10.1161/circulationaha.120.048739
https://doi.org/10.1161/circulationaha.120.048739