Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Allan B Okey"'
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e18337 (2011)
Rat is a major model organism in toxicogenomics and pharmacogenomics. Hepatic mRNA profiles after treatment with xenobiotic chemicals are used to predict and understand drug toxicity and mechanisms. Surprisingly, neither inter- and intra-strain varia
Externí odkaz:
https://doaj.org/article/830cde9a27824d7ba7a9e2b831c15394
Autor:
Stephenie D. Prokopec, Sandy Che Eun S. Lee, Amy X. Lu, Allan B. Okey, Rabah Soliymani, Cindy Q. Yao, John Douglas Mcpherson, Philip C. Zuzarte, John D. Watson, Michelle Sam, Raimo Pohjanvirta, Richard de Borja, Paul C. Boutros, Ren X. Sun, Ada Wong
The aryl hydrocarbon receptor (AHR) mediates many toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, the AHR alone does not explain the widely different outcomes among organisms. To identify the other factors involved, we evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59200aa2652ac064c46d809770637bc8
http://hdl.handle.net/10138/306416
http://hdl.handle.net/10138/306416
Autor:
Amy X. Lu, Sandy Che Eun S. Lee, Allan B. Okey, Ada Wong, Stephenie D. Prokopec, Ren X. Sun, John Douglas Mcpherson, Philip C. Zuzarte, Richard de Borja, John D. Watson, Michelle Sam, Cindy Q. Yao, Raimo Pohjanvirta, Paul C. Boutros
The aryl hydrocarbon receptor (AHR) mediates many of the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, the AHR alone is insufficient to explain the widely different outcomes among organisms. Attempts to identify unknown factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f3afa96c39d252d39109b98c0e19a4
Autor:
Kathleen E. Houlahan, Sanna Lensu, Paul C. Boutros, Stephenie D. Prokopec, Allan B. Okey, Ivy D. Moffat, Jere Lindén, Raimo Pohjanvirta
Publikováno v:
Toxicology. 328:93-101
In some mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as significant weight loss associated with lethal outcomes. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-r-dioxin (TCDD), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aa430328b3570a7778b03e7a18d54b
https://doi.org/10.1016/j.tox.2014.12.016
https://doi.org/10.1016/j.tox.2014.12.016
Autor:
Ivy D. Moffat, Cindy Q. Yao, Stephenie D. Prokopec, Ren X. Sun, Kathleen E. Houlahan, Christine P'ng, Paul C. Boutros, Renee Pang, Sanna Lensu, Lauren C. Chong, Ashley B. Smith, Jere Lindén, Alexander H. Wu, Allan B. Okey, Raimo Pohjanvirta, Jamie Lee, Nicholas J. Harding, John D. Watson
Publikováno v:
BMC genomics, vol 18, iss 1
BMC Genomics
BMC Genomics
Background 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e4c13ca0a2b47dfe7f3c7d824a29a8
https://escholarship.org/uc/item/081677v9
https://escholarship.org/uc/item/081677v9
Autor:
Stephenie D. Prokopec, Raimo Pohjanvirta, John D. Watson, Allan B. Okey, Ashley B. Smith, Paul C. Boutros
Publikováno v:
Archives of toxicology, vol 91, iss 1
Archives of Toxicology
Archives of Toxicology
2,3,7,8 Tetrachlorodibenzo-p-dioxin (TCDD) is an aromatic, long-lived environmental contaminant. While the pathogenesis of TCDD-induced toxicity is poorly understood, it has been shown that the aryl hydrocarbon receptor (AHR) is required. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50722dee8c1ece3950a545a8335d3a7b
https://escholarship.org/uc/item/4vw5q4cv
https://escholarship.org/uc/item/4vw5q4cv
Autor:
Nicholas J. Harding, Stephenie D. Prokopec, Raimo Pohjanvirta, Allan B. Okey, Cindy Q. Yao, Christine P'ng, John D. Watson, Lauren C. Chong, Paul C. Boutros, Renee Pang
Publikováno v:
Toxicology and Applied Pharmacology. 260:135-145
The biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been the subject of intense study for decades. It is now clear that essentially all TCDD-induced toxicities are mediated by DNA–protein interactions involving the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e0e529c7bde0c648d0b05bcbf1ecb3
https://doi.org/10.1016/j.taap.2012.02.001
https://doi.org/10.1016/j.taap.2012.02.001
Autor:
Allan B. Okey, Andrea Pansoy, Jason Matthews, Sharon K. Krueger, David E. Williams, Trine Celius, Marilyn C. Henderson
Publikováno v:
Toxicology and Applied Pharmacology. 247:60-69
Flavin-containing monooxygenases often are thought not to be inducible but we recently demonstrated aryl hydrocarbon receptor (AHR)-dependent induction of FMO mRNAs in mouse liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Celius et al., Drug Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::361d76459794ed06ac76146978249d0d
https://doi.org/10.1016/j.taap.2010.05.018
https://doi.org/10.1016/j.taap.2010.05.018
Autor:
Michelle Cotterchio, Michael Manno, Patricia A. Harper, Beatrice A. Boucher, Allan B. Okey, Steven Gallinger
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 17:3098-3107
Colorectal cancer literature regarding the interaction between polymorphisms in carcinogen-metabolizing enzymes and red meat intake/doneness is inconsistent. A case-control study was conducted to evaluate the interaction between red meat consumption,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f61de4e64b9e18838ee853e7c68486
https://doi.org/10.1158/1055-9965.epi-08-0341
https://doi.org/10.1158/1055-9965.epi-08-0341
Publikováno v:
Molecular Pharmacology. 72:956-966
The AHR locus encodes the aryl hydrocarbon receptor (AHR), a transcriptional regulator of multiple drug-metabolizing enzymes and mediator of toxicity of dioxin-like chemicals. The Han/Wistar (Kuopio) rat strain (H/W) is remarkably resistant to lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c59e64f738387bf89011a15f0be2a6
https://doi.org/10.1124/mol.107.037218
https://doi.org/10.1124/mol.107.037218