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Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severity

Autor: Andina, Nicola, de Meuron, Louise, Schnegg-Kaufmann, Annatina Sarah, Ansermet, Camille, Bombaci, Giuseppe, Keller, Nino, Porret, Naomi, Angelillo-Scherrer, Anne, Bonadies, Nicolas, Allam, Ramanjaneyulu

Publikováno v: Andina, Nicola; de Meuron, Louise; Schnegg-Kaufmann, Annatina Sarah; Ansermet, Camille; Bombaci, Giuseppe; Keller, Nino; Porret, Naomi; Angelillo-Scherrer, Anne; Bonadies, Nicolas; Allam, Ramanjaneyulu (31 January 2022). Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severity (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2022.01.27.477992

Aging causes chronic low-grade inflammation known as inflamm-aging. It is a risk factor for chronic myelomonocytic leukemia (CMML), a hematological malignancy that is most prevalent in older people. Recent studies suggest a critical role for the NLRP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8ff91a6423e690c17e6dcdfdf348f3

LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity

Autor: Bombaci, Giuseppe, Sarangdhar, Mayuresh Anant, Andina, Nicola, Tardivel, Aubry, Yu, Eric Chi-Wang, Mackie, Gillian M, Pugh, Matthew, Ozan, Vedat Burak, Banz, Yara, Spinetti, Thibaud, Hirzel, Cedric, Youd, Esther, Schefold, Joerg C, Taylor, Graham, Gazdhar, Amiq, Bonadies, Nicolas, Angelillo-Scherrer, Anne, Schneider, Pascal, Maslowski, Kendle M, Allam, Ramanjaneyulu

Publikováno v: Life science alliance, vol. 5, no. 6, pp. e202101226
Bombaci, Giuseppe; Sarangdhar, Mayuresh Anant; Andina, Nicola; Tardivel, Aubry; Yu, Eric Chi-Wang; Mackie, Gillian M; Pugh, Matthew; Ozan, Vedat Burak; Banz, Yara; Spinetti, Thibaud; Hirzel, Cédric; Youd, Esther; Schefold, Joerg C; Taylor, Graham; Gazdhar, Amiq; Bonadies, Nicolas; Angelillo-Scherrer, Anne; Schneider, Pascal; Maslowski, Kendle M and Allam, Ramanjaneyulu (2022). LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. Life science alliance, 5(6) EMBO Press 10.26508/lsa.202101226

Inflammasomes are cytosolic innate immune sensors of pathogen infection and cellular damage that induce caspase-1-mediated inflammation upon activation. Although inflammation is protective, uncontrolled excessive inflammation can cause inflammatory d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488bbd9efd7f819f11109a566511bb94
https://pubmed.ncbi.nlm.nih.gov/35256513

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