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In vitro modulator responsiveness of 655 CFTR variants found in people with cystic fibrosis.

Autor: Bihler H; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Sivachenko A; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Millen L; University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Bhatt P; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Patel AT; Rosalind Franklin University Medical School, Chicago, IL 60064, USA., Chin J; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Bailey V; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Musisi I; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., LaPan A; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Allaire NE; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Conte J; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA., Simon NR; University of Washington, Seattle, WA 98195-9300, USA., Magaret AS; University of Washington, Seattle, WA 98195-9300, USA., Raraigh KS; Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA., Cutting GR; Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA., Skach WR; Cystic Fibrosis Foundation, Bethesda, MD 20814, USA., Bridges RJ; Rosalind Franklin University Medical School, Chicago, IL 60064, USA., Thomas PJ; University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mense M; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA. Electronic address: mmense@cff.org.

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2024 Jul; Vol. 23 (4), pp. 664-675. Date of Electronic Publication: 2024 Feb 22.

Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation.

Autor: Delbridge ARD; Multiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States., Huh D; Translational Biology, Biogen, Cambridge, MA, United States., Brickelmaier M; Multiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States., Burns JC; Multiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States., Roberts C; Translational Biology, Biogen, Cambridge, MA, United States., Challa R; Translational Biology, Biogen, Cambridge, MA, United States., Raymond N; Multiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States., Cullen P; Translational Biology, Biogen, Cambridge, MA, United States., Carlile TM; Translational Biology, Biogen, Cambridge, MA, United States., Ennis KA; Genetic and Neurodevelopmental Disorders, Biogen, Cambridge, MA, United States., Liu M; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States., Sun C; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States., Allaire NE; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States., Foos M; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA, United States., Tsai HH; Multiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States., Franchimont N; MS Immunology Development Unit, Biogen, Cambridge, MA, United States., Ransohoff RM; Multiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States., Butts C; Digital & Quantitative Medicine, Biogen, Cambridge, MA, United States., Mingueneau M; Multiple Sclerosis and Neuroimmunology Research Unit, Biogen, Cambridge, MA, United States.

Publikováno v: Frontiers in cellular neuroscience [Front Cell Neurosci] 2020 Dec 21; Vol. 14, pp. 592005. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).

Isogenic cell models of cystic fibrosis-causing variants in natively expressing pulmonary epithelial cells.

Autor: Valley HC; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Bukis KM; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Bell A; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Cheng Y; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Wong E; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Jordan NJ; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Allaire NE; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Sivachenko A; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Liang F; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Bihler H; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Thomas PJ; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA; University of Texas - Southwestern, UT Southwestern Medical Ctr., 6001 Forrest Park Rd ND12.126B, Dallas, TX 75390-9040, USA., Mahiou J; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA., Mense M; Cystic Fibrosis Foundation, CFFT Lab, 44 Hartwell Ave., Lexington, MA 02421, USA. Electronic address: mmense@cff.org.

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2019 Jul; Vol. 18 (4), pp. 476-483. Date of Electronic Publication: 2018 Dec 15.