Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice

Autor: Allain-Thibeault Ferhat, Elisabeth Verpy, Anne Biton, Benoît Forget, Fabrice De Chaumont, Florian Mueller, Anne-Marie Le Sourd, Sabrina Coqueran, Julien Schmitt, Christelle Rochefort, Laure Rondi-Reig, Aziliz Leboucher, Anne Boland, Bertrand Fin, Jean-François Deleuze, Tobias M. Boeckers, Elodie Ey, Thomas Bourgeron

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Autism is characterized by atypical social communication and stereotyped behaviors. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are detected in 1–2% of patients with autism and intellectual disability, but the mechanisms

Externí odkaz: https://doaj.org/article/1f5100953b6448ccaffca7973b2673db

Social communication in mice--are there optimal cage conditions?

Autor: Allain-Thibeault Ferhat, Anne-Marie Le Sourd, Fabrice de Chaumont, Jean-Christophe Olivo-Marin, Thomas Bourgeron, Elodie Ey

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121802 (2015)

Social communication is heavily affected in patients with neuropsychiatric disorders. Accordingly, mouse models designed to study the mechanisms leading to these disorders are tested for this phenotypic trait. Test conditions vary between different m

Externí odkaz: https://doaj.org/article/aa741c030773410a8129a5d48a8e3965

Shank2 Mutant Mice Display Hyperactivity Insensitive to Methylphenidate and Reduced Flexibility in Social Motivation, but Normal Social Recognition

Autor: Fabrice de Chaumont, Tobias M. Boeckers, Nicolas Torquet, Thomas Bourgeron, Anne-Marie Le Sourd, Julie Lévi-Strauss, Elodie Ey, Allain-Thibeault Ferhat

Publikováno v: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Frontiers Media, 2018, 11, pp.365. ⟨10.3389/fnmol.2018.00365⟩
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Frontiers in Molecular Neuroscience, 2018, 11, pp.365. ⟨10.3389/fnmol.2018.00365⟩

International audience; Mouse models of autism can be used to study evolutionarily conserved mechanisms underlying behavioral abnormalities in social communication and repetitive behaviors. SHANK genes code for synaptic scaffolding proteins at excita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f0874517df4ad6d7814e7212d24155
https://hal-pasteur.archives-ouvertes.fr/pasteur-02344332/file/ey-et-al_2018_shank2_mph_social_motivation.pdf

Social communication in mice--are there optimal cage conditions?

Autor: Jean-Christophe Olivo-Marin, Anne-Marie Le Sourd, Elodie Ey, Allain-Thibeault Ferhat, Fabrice de Chaumont, Thomas Bourgeron

Publikováno v: PLoS ONE
PLoS ONE, 2015, 10 (3), pp.e0121802. ⟨10.1371/journal.pone.0121802⟩
PLoS ONE, Vol 10, Iss 3, p e0121802 (2015)
PLoS ONE, Public Library of Science, 2015, 10 (3), pp.e0121802. ⟨10.1371/journal.pone.0121802⟩

International audience; Social communication is heavily affected in patients with neuropsychiatric disorders. Accordingly, mouse models designed to study the mechanisms leading to these disorders are tested for this phenotypic trait. Test conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced123e01286ec05e4ef6c7b15027a2c
https://hal-pasteur.archives-ouvertes.fr/pasteur-01470225/file/ferhat-et-al_2015_social_com_cages.pdf