Výsledky vyhledávání - "Alla Klyuyeva"

Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes

Autor: Olga V. Belyaeva, Wojciech Krezel, Kelli R. Goggans, Kirill M. Popov, Natalia Y. Kedishvili, Alla Klyuyeva

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2021, 296, ⟨10.1016/j.jbc.2021.100323⟩
The Journal of Biological Chemistry

Liver is the central metabolic hub that coordinates carbohydrate and lipid metabolism. The bioactive derivative of vitamin A, retinoic acid (RA), was shown to regulate major metabolic genes including phosphoenolpyruvate carboxykinase, fatty acid synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482164d931d63e8619988426a47c4614
https://hal.science/hal-03708081

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Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids

Autor: Kelli R. Goggans, Alla Klyuyeva, Natalia Y. Kedishvili, Olga V. Belyaeva

Several human enzymes of the short-chain dehydrogenase/reductase (SDR) superfamily of proteins exhibit catalytic oxidoreductive activity toward retinoid substrates in vitro. For some retinoid-active enzymes, their physiological significance for retin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7e44f9219cf5d79cbb69bfeee9057bb
https://doi.org/10.1016/bs.mie.2020.02.013

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Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex

Autor: Alina Tuganova, Alla Klyuyeva, Kirill M. Popov, Natalia Y. Kedishvili

The pyruvate dehydrogenase complex (PDC) is a multienzyme assembly that converts pyruvate to acetyl-CoA. As pyruvate and acetyl-CoA play central roles in cellular metabolism, understanding PDC regulation is pivotal to understanding the larger metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7374d3dd5c092c299c138b8f8ada49d3
https://europepmc.org/articles/PMC6341403/

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Allosteric Coupling in Pyruvate Dehydrogenase Kinase 2

Autor: Alla Klyuyeva, Alina Tuganova, Kirill M. Popov

Publikováno v: Biochemistry. 47:8358-8366

Mitochondrial pyruvate dehydrogenase kinase 2 (PDHK2) phosphorylates the pyruvate dehydrogenase multienzyme complex (PDC) and thereby controls the rate of oxidative decarboxylation of pyruvate. The activity of PDHK2 is regulated by a variety of metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76aaad8e5bd74358fa9758f354de4141
https://doi.org/10.1021/bi800631h

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Structural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2

Autor: Alina Tuganova, Ming Luo, Todd Green, Alla Klyuyeva, Alexei Grigorian, Kirill M. Popov

Publikováno v: Journal of Biological Chemistry. 283:15789-15798

PDHK2 is a mitochondrial protein kinase that phosphorylates pyruvate dehydrogenase complex, thereby down-regulating the oxidation of pyruvate. Here, we present the crystal structure of PDHK2 bound to the inner lipoyl-bearing domain of dihydrolipoamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ce7695e68c4a5c67eaa7183ccb830b
https://doi.org/10.1074/jbc.m800311200

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Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2

Autor: Alina Tuganova, and Alla Klyuyeva, Kirill M. Popov

Publikováno v: Biochemistry. 46(29)

Pyruvate dehydrogenase kinase 2 (PDHK2) is a unique mitochondrial protein kinase that regulates the activity of the pyruvate dehydrogenase multienzyme complex (PDC). PDHK2 is an integral component of PDC tightly bound to the inner lipoyl-bearing doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e413694f1c9e7a142ac8518a8d6e74
https://pubmed.ncbi.nlm.nih.gov/17602666

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Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2

Autor: Alina Tuganova, Alla Klyuyeva, Kirill M. Popov

Publikováno v: FEBS letters. 581(16)

Dichloroacetate (DCA) is a promising anticancer and antidiabetic compound targeting the mitochondrial pyruvate dehydrogenase kinase (PDHK). This study was undertaken in order to map the DCA-binding site of PDHK2. Here, we present evidence that R114,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ecf099aa4168ed02de1391ef0e01f6
https://pubmed.ncbi.nlm.nih.gov/17544412

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