Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alla Kachko"'
Publikováno v:
EBioMedicine, Vol 2, Iss 8, Pp 859-867 (2015)
Vaccine reverse engineering is emerging as an important approach to vaccine antigen identification, recently focusing mainly on structural characterization of interactions between neutralizing monoclonal antibodies (mAbs) and antigens. Using mAbs tha
Externí odkaz:
https://doaj.org/article/cf5a6f0ff5d64e8fbb67641eb40a45d4
Autor:
Wendy G Tan, Iryna Zubkova, Alla Kachko, Frances Wells, Heiko Adler, Gerd Sutter, Marian E Major
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181578 (2017)
T-cell based vaccines have been considered as attractive candidates for prevention of hepatitis C virus (HCV) infections. In this study we compared the magnitude and phenotypic characteristics of CD8+ T-cells induced by three commonly used viral vect
Externí odkaz:
https://doaj.org/article/2229ae1085654a6284af5f2bf284757e
Autor:
Alexander Gutfraind, Basmattee Boodram, Kimberly Page, Qingwen Cui, Behzad Hajarizadeh, Rachel Sacks-Davis, Harel Dahari, Alla Kachko, Louis M. Shekhtman, Scott J. Cotler, Marian E. Major
Publikováno v:
Science Translational Medicine. 10
The major route of hepatitis C virus (HCV) transmission in the United States is injection drug use. We hypothesized that if a HCV vaccine was available, vaccination could impact HCV transmission among people who inject drugs by reducing HCV titers af
Autor:
Marian E. Major, Iryna Zubkova, Maria Isabel Costafreda, Frances Wells, Kazuyo Takeda, Jerome Jacques, Alla Kachko, Gerardo G. Kaplan
Publikováno v:
Journal of Virology. 92
Hepatitis C virus (HCV) is the leading cause of chronic hepatitis in humans. Several host molecules participate in HCV cell entry, but this process remains unclear. The complete unraveling of the HCV entry process is important to further understand v
Autor:
Sharon E. Frey, Pei Zhang, Frances Wells, Alla Kachko, Lev Sirota, Marian E. Major, Ranjit Ray, Iryna Zubkova
Publikováno v:
Hepatology
Hepatitis C virus (HCV) neutralization occurring at the E2 region 412-426 (EP-I) could be enhanced when antibodies directed specifically to the E2 region 434-446 (EP-II) were removed from serum samples of persistently infected patients and vaccinated
Publikováno v:
EBioMedicine
EBioMedicine, Vol 2, Iss 8, Pp 859-867 (2015)
EBioMedicine, Vol 2, Iss 8, Pp 859-867 (2015)
Vaccine reverse engineering is emerging as an important approach to vaccine antigen identification, recently focusing mainly on structural characterization of interactions between neutralizing monoclonal antibodies (mAbs) and antigens. Using mAbs tha
Autor:
Gerd Sutter, Iryna Zubkova, Marian E. Major, Wendy G. Tan, Frances Wells, Alla Kachko, Heiko Adler
Publikováno v:
PLoS ONE 12:e0181578 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181578 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181578 (2017)
T-cell based vaccines have been considered as attractive candidates for prevention of hepatitis C virus (HCV) infections. In this study we compared the magnitude and phenotypic characteristics of CD8+ T-cells induced by three commonly used viral vect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cf25e33348cccd10576e6cf39596ae
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51566
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51566
Autor:
Steven A. Rubin, Iryna Zubkova, Carole A. Bewley, Marian E. Major, Syed Shahzad-ul-Hussan, Kazuyo Takeda, Sandra Loesgen, Wendy G. Tan, Alla Kachko, Frances Wells
Publikováno v:
Molecular pharmaceutics. 10(12)
Plant or microbial lectins are known to exhibit potent antiviral activities against viruses with glycosylated surface proteins, yet the mechanism(s) by which these carbohydrate-binding proteins exert their antiviral activities is not fully understood
Autor:
Michael Merchlinsky, Aleksander Shvalov, Alla Kachko, Sergei Netesov, Iryna Zubkova, Marian E. Major, Frances Wells, G. F. Sivolobova, Ollie Williams, Valeriy Loktev, Hisayoshi Watanabe, A. V. Ivanova, A. A. Grazhdantseva, Galina V. Kochneva, Tatyana Lupan
Publikováno v:
Publons
ResearcherID
ResearcherID
One of the greatest challenges to HCV vaccine development is the induction of effective immune responses using recombinant proteins or vectors. In order to better understand which vaccine-induced antibodies contribute to neutralization of HCV the qua
Publikováno v:
Virus research. 153(1)
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in primates, whereas in guinea pigs it induces a nonlethal infection with a mild fever and subsequent recovery. We performed 7 selective passages in guinea pigs resulted in obtaining of guinea