Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Alla Grishok"'
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-27 (2022)
Abstract Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the triplication of the critical region of human chromosome 21 (HSA21). Major studies were conducted in recent years to gain an understanding about the
Externí odkaz:
https://doaj.org/article/d3556d7e9d724bfcbb0bc845bba457ce
Publikováno v:
BBA Advances, Vol 3, Iss , Pp 100080- (2023)
Methylation of histone H3 at lysine 79 (H3K79) is conserved from yeast to humans and is accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C. elegans enzyme DOT-1.1 and its interacting partners are similar to the mammal
Externí odkaz:
https://doaj.org/article/cfc86ec5313c4a9b85d04dbc8f50672a
Autor:
Nava Zaarur, Kathleen Desevin, James Mackenzie, Avery Lord, Alla Grishok, Konstantin V. Kandror
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp 75-82 (2019)
Objective: Animal lifespan is controlled through genetic pathways that are conserved from nematodes to humans. Lifespan-promoting conditions in nematodes include fasting and a reduction of insulin/IGF signaling. Here we aimed to investigate the input
Externí odkaz:
https://doaj.org/article/ac94fd6ec3d54561be7ba3fe150bb6db
Autor:
Laura I Lascarez-Lagunas, Esther Herruzo, Alla Grishok, Pedro A San-Segundo, Mónica P Colaiácovo
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009171 (2020)
Epigenetic modifiers are emerging as important regulators of the genome. However, how they regulate specific processes during meiosis is not well understood. Methylation of H3K79 by the histone methyltransferase Dot1 has been shown to be involved in
Externí odkaz:
https://doaj.org/article/1d2bc3070aa04de7829edcf062d6d680
Autor:
Ruben Esse, Alla Grishok
Publikováno v:
Cells, Vol 9, Iss 8, p 1846 (2020)
The methylation of histone H3 at lysine 79 is a feature of open chromatin. It is deposited by the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 methylation (H3K79me) have been correlated with enhancers in C. elegans
Externí odkaz:
https://doaj.org/article/270efdad5a06415f879b9ee9ffb987f5
Autor:
Alla Grishok
Publikováno v:
DNA
DNA is central to the propagation and evolution of most living organisms due to the essential process of its self-replication. Yet it also encodes factors that permit epigenetic (not included in DNA sequence) flow of information from parents to their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0056601168007a2554f021efb1c34ceb
http://europepmc.org/articles/PMC8556531
http://europepmc.org/articles/PMC8556531
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 996-1009 (2013)
Neuronal migration is essential for nervous system development in all organisms and is regulated in the nematode, C. elegans, by signaling pathways that are conserved in humans. Here, we demonstrate that the insulin/IGF-1-PI3K signaling pathway modul
Externí odkaz:
https://doaj.org/article/2150068a6ebd4df6829dad0ecb6e9ba8
Autor:
Germano Cecere, Alla Grishok
Publikováno v:
Bio-Protocol, Vol 4, Iss 24 (2014)
The RNA chromatin immunoprecipitation assay (RNA-ChIP) allows detection and quantification of RNA–protein interactions using in vivo cross-linking with formaldehyde followed by immunoprecipitation of the RNA–protein complexes. Here we describe th
Externí odkaz:
https://doaj.org/article/097f50a6cb154a77b6d4fac5aa58d2d0
Publikováno v:
RNA. 25:1259-1273
Methylation of histone H3 on lysine 79 (H3K79) by DOT1L is associated with actively transcribed genes. Earlier, we described that DOT-1.1, the Caenorhabditis elegans homolog of mammalian DOT1L, cooperates with the chromatin-binding protein ZFP-1 (AF1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f28877bb8b321eaad92a52fb63f66c9e
https://doi.org/10.1261/rna.070292.119
https://doi.org/10.1261/rna.070292.119
Autor:
Andres R Mansisidor, Germano Cecere, Sebastian Hoersch, Morten B Jensen, Trupti Kawli, Lisa M Kennedy, Violeta Chavez, Man-Wah Tan, Jason D Lieb, Alla Grishok
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002299 (2011)
Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studyin
Externí odkaz:
https://doaj.org/article/952a7a01c6164bd3a0e7659bb4b9b77f