Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alla, Pryyma"'
Autor:
Alla Pryyma, David M. Perrin, Yong Jia Bu, Helen Merkens, Francois Benard, Zhengxing Zhang, Kaveh Matinkhoo
Publikováno v:
RSC Chemical Biology
Targeted cancer therapy represents a paradigm-shifting approach that aims to deliver a toxic payload selectively to target-expressing cells thereby sparing normal tissues the off-target effects associated with traditional chemotherapeutics. Since mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9780a4dfdb21b9c3769d74e52efc071a
https://doi.org/10.1039/d1cb00036e
https://doi.org/10.1039/d1cb00036e
Publikováno v:
The Journal of Organic Chemistry. 86:5362-5370
Here we report a scalable synthesis of the key amino acid residue, (2S,3R,4R)-4,5-dihydroxyisoleucine (DHIle) in α-amanitin, that in turn enables the scalable synthesis of an equipotent analogue, Asn(N-ethylazide)-S,6'-dideoxy-α-amanitin, suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de961133eb8b13fe7eef932da54baecb
https://doi.org/10.1021/acs.joc.0c03022
https://doi.org/10.1021/acs.joc.0c03022
Autor:
Mihajlo Todorovic, Paul Rivollier, Antonio A. W. L. Wong, Zhou Wang, Alla Pryyma, Tuan Trung Nguyen, Kayla C. Newell, Juliette Froelich, David M. Perrin
Publikováno v:
Journal of medicinal chemistry. 65(15)
For 70 years, α-amanitin, the most cytotoxic peptide in its class, has been without a synthetic rival; through synthesis, we address the structure-activity relationships to inform the design of new amatoxins and disclose analogues that are more cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49543a0f84695a59e77bf9210066ab09
https://pubmed.ncbi.nlm.nih.gov/35696491
https://pubmed.ncbi.nlm.nih.gov/35696491
Publikováno v:
Chemical communications (Cambridge, England). 57(75)
Amanitin is used extensively as a research tool to inhibit RNA Pol II thereby implicating its role in mRNA transcription. Recently, amanitin has gained traction as a toxic payload for targeted therapy. Here we report the first-ever photocaged amaniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5c74f72efb965a0b652db46395f3d48
https://pubmed.ncbi.nlm.nih.gov/34477193
https://pubmed.ncbi.nlm.nih.gov/34477193
Autor:
Jinhe Pan, Zhibo Liu, Áron Roxin, Helen Merkens, Hsiou-Ting Kuo, Chengcheng Zhang, Francois Benard, Alla Pryyma, Kuo-Shyan Lin, Mathieu L. Lepage, David M. Perrin, Zhengxing Zhang
Publikováno v:
Journal of Nuclear Medicine. 60:1160-1166
After the identification of the high-affinity glutamate-ureido scaffold, the design of several potent 18F- and 68Ga-labeled tracers has allowed spectacular progress in imaging recurrent prostate cancer by targeting the prostate-specific membrane anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6eea4853aeae3edb629a6d180d67db5
https://doi.org/10.2967/jnumed.118.216598
https://doi.org/10.2967/jnumed.118.216598
Publikováno v:
Chemical Science
Appreciating the need to access synthetic analogs of amanitin, here we report the synthesis of 5′-hydroxy-6′-deoxy-amanitin, a novel, rationally-designed bioactive analog and constitutional isomer of α-amanitin, that is anticipated to be used as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60896f79ed1c390436c9396265cce77
https://pubmed.ncbi.nlm.nih.gov/34094418
https://pubmed.ncbi.nlm.nih.gov/34094418
Publikováno v:
The Journal of organic chemistry. 86(7)
Here we report a scalable synthesis of the key amino acid residue, (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ad10886c2e30edc6cc8d771286c5f16
https://pubmed.ncbi.nlm.nih.gov/33710901
https://pubmed.ncbi.nlm.nih.gov/33710901
Publikováno v:
Journal of the American Chemical Society. 140:6513-6517
α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells. Recent interest in α-amanitin arises from its prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb5a291832ff26810ff0e66c42cfa83
https://doi.org/10.1021/jacs.7b12698
https://doi.org/10.1021/jacs.7b12698
Publikováno v:
Organic letters. 21(20)
Indole dearomatization of tryptophan represents a key approach in the synthesis of indole containing alkaloids. Although the reactivity of C-3a-bromo-, 3a-iodo-, and 3a-chloropyrroloindolines has been explored, the utility and reactivity of C-3a-fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b57643cceeec9e93430c9758162d9b
https://pubmed.ncbi.nlm.nih.gov/31596101
https://pubmed.ncbi.nlm.nih.gov/31596101
Autor:
Hsiou-Ting, Kuo, Mathieu L, Lepage, Kuo-Shyan, Lin, Jinhe, Pan, Zhengxing, Zhang, Zhibo, Liu, Alla, Pryyma, Chengcheng, Zhang, Helen, Merkens, Aron, Roxin, David M, Perrin, François, Bénard
Publikováno v:
Journal of Nuclear Medicine
After the identification of the high-affinity glutamate-ureido scaffold, the design of several potent 18F- and 68Ga-labeled tracers has allowed spectacular progress in imaging recurrent prostate cancer by targeting the prostate-specific membrane anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2625bce34398598bb409e379ad2cbf78
https://pubmed.ncbi.nlm.nih.gov/30737299
https://pubmed.ncbi.nlm.nih.gov/30737299