The genetic nomenclature of recessive cerebellar ataxias

Autor: Rossi, Malco, Anheim, Mathieu, Durr, Alexandra, Klein, Christine, Koenig, Michel, Synofzik, Matthis, Marras, Connie, van de Warrenburg, Bart P, Disorders, International Parkinson and Movement Disorder Society Task Force on Classification and Nomenclature of Genetic Movement

Publikováno v: Movement Disorders, 33, 1056-1076
Movement Disorders
Movement Disorders, Wiley, 2018, 33 (7), pp.1056--1076. ⟨10.1002/mds.27415⟩
Movement Disorders, 33, 7, pp. 1056-1076
Movement disorders 33(7), 1056-1076 (2018). doi:10.1002/mds.27415

International audience; The recessive cerebellar ataxias are a large group of degenerative and metabolic disorders, the diagnostic management of which is difficult because of the enormous clinical and genetic heterogeneity. Because of several limitat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cd40aaed9254eb3aa183566117ceb693
http://hdl.handle.net/2066/196558

Optimization of a Pipemidic Acid Autotaxin Inhibitor

Autor: Daniel L. Baker, Angela L. Howard, Irene W. Wanjala, Heidi E. Bostic, Michael D. Best, Abby L. Parrill, Adrienne B. Hoeglund

Publikováno v: Journal of Medicinal Chemistry. 53:1056-1066

Autotaxin (ATX, NPP2) has recently been shown to be the lysophospholipase D responsible for synthesis of the bioactive lipid lysophosphatidic acid (LPA). LPA has a well-established role in cancer, and the production of LPA is consistent with the canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339ead79ee3c8cd117cde4f000f53710
https://doi.org/10.1021/jm9012328

Production of Lysophosphatidic Acid in Blister Fluid: Involvement of a Lysophospholipase D Activity

Autor: Josette Fauvel, Madie Fanguin, Sandra Grès, Hugues Chap, Jean-Pierre Salles, Jean-Sébastien Saulnier-Blache, Clotilde Cariven, Bertrand Perret, Juliette Mazereeuw-Hautier

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2005, 125 (3), pp.421-7. ⟨10.1111/j.0022-202X.2005.23855.x⟩
Journal of Investigative Dermatology, 2005, 125 (3), pp.421-7. ⟨10.1111/j.0022-202X.2005.23855.x⟩

Lysophosphatidic acid (LPA) is present in abundance in serum resulting from platelet activation and is also found in other biological fluids. LPA controls numerous cellular responses and plays a role in specific functions such as wound healing, espec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699e8b86b581fe4a09006a24103d89c7

Production of Lysophosphatidic Acids by Lysophospholipase D in Human Follicular Fluids of In Vitro Fertilization Patients1

Autor: Yuko Nishioka, Maki Miyake, Toshihiro Aono, Kenji Fukuzawa, Akira Tokumura, Shuji Yamano

Publikováno v: Biology of Reproduction. 61:195-199

Lysophosphatidic acids (LPAs) are known to be normal constituents of mammalian serum, and they mimic some biological effects of the serum. We previously reported that lysophospholipase D (LPLD) was involved in the accumulation of LPAs in incubated ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4804f88035ed0b5ec64de5d160daac0
https://doi.org/10.1095/biolreprod61.1.195

The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells

Autor: Jens Wulfaenger, Friedrich Haag, Cuong Hoang-Vu, Thomas Klonisch, Henning Dralle, Anja Seifert, Jürgen Langner, Astrid Kehlen

Publikováno v: Oncology reports. 19(6)

Autotaxin (ATX/NPP2) shows a nucleotide pyrophosphatase/phosphodiesterase and lysophospholipase D (lysoPLD) activity and is a member of a family of structurally-related mammalian ecto-nucleotide pyrophosphate/phosphodiesterases (E-NPP1-3). ATX is uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6eb8c408906e2dc6a2ec4b5b8ee7f4
https://pubmed.ncbi.nlm.nih.gov/18497954