Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway

Autor: Pascale A, Amadio M, Scapagnini G, Lanni C, Racchi M, Provenzani A, Govoni S, Alkon DL, Quattrone A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 12065–12070.
info:cnr-pdr/source/autori:Pascale A, Amadio M, Scapagnini G, Lanni C, Racchi M, Provenzani A, Govoni S, Alkon DL, Quattrone A./titolo:Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway./doi:/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2005/pagina_da:12065/pagina_a:12070/intervallo_pagine:12065–12070/volume:102

More than 1 in 20 human genes bear in the mRNA 3' UTR a specific motif called the adenine- and uridine-rich element (ARE), which posttranscriptionally determines its expression in response to cell environmental signals. ELAV (embryonic lethal abnorma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0adb00f4f74771ce5f1bd6e7b038b000
http://hdl.handle.net/11695/7950

Regional rat brain distribution of heme oxygenase-1 and manganese superoxide dismutase mRNA: relevance of redox homeostasis in the aging processes

Autor: Colombrita C 2, Calabrese V 2, Stella AM 2, Mattei F 2, Alkon DL 2, Scapagnini G 1

Publikováno v: 228 (2003): 517–524.
info:cnr-pdr/source/autori:Colombrita C 2, Calabrese V 2, Stella AM 2, Mattei F 2, Alkon DL 2, Scapagnini G 1/titolo:Regional rat brain distribution of heme oxygenase-1 and manganese superoxide dismutase mRNA: relevance of redox homeostasis in the aging processes./doi:/rivista:/anno:2003/pagina_da:517/pagina_a:524/intervallo_pagine:517–524/volume:228

Increasing evidence supports the notion that reduction of cellular expression and activity of antioxidant proteins and the resulting increase of oxidative stress are fundamental causes in the aging processes and neurodegenerative diseases. In the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::03d10e17ea85a07134dfcf5653f4f6ac
http://www.cnr.it/prodotto/i/49894

Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain

Autor: Zhoar O 1, Cavallaro 2, V D'Agata 2, Alkon DL 1

Publikováno v: Brain research 115 (2003): 63–68.
info:cnr-pdr/source/autori:Zhoar O 1, Cavallaro 2, V D'Agata 2, Alkon DL 1/titolo:Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain/doi:/rivista:Brain research/anno:2003/pagina_da:63/pagina_a:68/intervallo_pagine:63–68/volume:115

Beta-amyloid (Abeta) is formed by sequential cleaving of the amyloid precursor protein by two proteolytic enzymes, beta- and gamma-secretases. Beta-secretase (BACE) is a type I transmembrane aspartic proteinase that is highly expressed in the mammali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::eaa17012143d2bc345f8b1d9fc154443
http://www.cnr.it/prodotto/i/49850

[12] Identification of ion channel regulating proteins by patch-clamp analysis

Autor: Alkon Dl, Thomas J. Nelson, Gusev Pa

Publisher Summary Microinjection of proteins into living cells permits measurement of physiologic activity under conditions in which the normal electrical activity of the cell is preserved. Alternatively, sections of membrane can be analyzed by the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e75058acae4e62400f52cf66b39bf00e
https://doi.org/10.1016/s0076-6879(98)93015-4

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