Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): A prospective observational cohort study

Autor: Matthay, Michael, Orwoll, BE, Spicer, AC, Zinter, MS, Alkhouli, MF, Khemani, RG, Flori, HR, Neuhaus, JM, Calfee, CS, Matthay, MA, Sapru, A

Publikováno v: Matthay, Michael; Orwoll, BE; Spicer, AC; Zinter, MS; Alkhouli, MF; Khemani, RG; et al.(2015). Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): A prospective observational cohort study. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6vc1x0gs

© 2015 Orwoll et al.Introduction: The significance of endothelial injury in children with the acute respiratory distress syndrome (ARDS) has not been well studied. Plasma levels of soluble thrombomodulin (sTM), an endothelial surface protein involve

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Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome

Autor: Sapru, A, Calfee, CS, Liu, KD, Kangelaris, K, Hansen, H, Pawlikowska, L, Ware, LB, Alkhouli, MF, Abbot, J, Matthay, MA, The, NAN

Publikováno v: Intensive care medicine, vol 41, iss 3
Sapru, A; Calfee, CS; Liu, KD; Kangelaris, K; Hansen, H; Pawlikowska, L; et al.(2015). Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Medicine. doi: 10.1007/s00134-015-3648-x. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7bq8q4qk

ObjectiveThombomodulin (TM) is an activator of protein C and a biomarker for endothelial injury. We hypothesized that (1) elevated plasma levels would be associated with clinical outcomes and (2) polymorphisms in the TM gene would be associated with

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The association of immediate post cardiac arrest diastolic hypertension and survival following pediatric cardiac arrest.

Autor: Topjian AA; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: topjian@email.chop.edu., Sutton RM; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Reeder RW; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Telford R; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Meert KL; Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI, United States., Yates AR; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, United States., Morgan RW; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Berger JT; Department of Pediatrics, Children's National Medical Center, Washington D.C., United States., Newth CJ; Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, United States., Carcillo JA; Department of Critical Care Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States., McQuillen PS; Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, United States., Harrison RE; Department of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, United States., Moler FW; Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, MI, United States., Pollack MM; Department of Pediatrics, Children's National Medical Center, Washington D.C., United States; Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ, United States., Carpenter TC; Department of Pediatrics, Denver Children's Hospital, University of Colorado, Denver, CO, United States., Notterman DA; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States., Holubkov R; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Dean JM; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Nadkarni VM; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Berg RA; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Zuppa AF; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Graham K; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Twelves C; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Diliberto MA; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Landis WP; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States., Tomanio E; Department of Pediatrics, Children's National Medical Center, Washington D.C., United States., Kwok J; Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, United States., Bell MJ; Department of Pediatrics, Children's National Medical Center, Washington D.C., United States; Department of Critical Care Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States., Abraham A; Department of Critical Care Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States., Sapru A; Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, United States; Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, United States., Alkhouli MF; Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, United States., Heidemann S; Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI, United States., Pawluszka A; Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI, United States., Hall MW; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, United States., Steele L; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, United States., Shanley TP; Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, MI, United States; Department of Pediatrics, Lurie Children's Hospital, Northwestern University, Chicago, IL, United States., Weber M; Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, MI, United States., Dalton HJ; Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ, United States., Bell A; Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ, United States., Mourani PM; Department of Pediatrics, Denver Children's Hospital, University of Colorado, Denver, CO, United States., Malone K; Department of Pediatrics, Denver Children's Hospital, University of Colorado, Denver, CO, United States., Locandro C; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Coleman W; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Peterson A; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Thelen J; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States., Doctor A; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States.

Publikováno v: Resuscitation [Resuscitation] 2019 Aug; Vol. 141, pp. 88-95. Date of Electronic Publication: 2019 Jun 06.

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.

Autor: Alkhouli MF; Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA., Hung J; Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA., Squire M; Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA., Anderson M; Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA., Castro M; Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA., Babu JR; Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, USA., Al-Nakkash L; Department of Physiology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA., Broderick TL; Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA., Plochocki JH; Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA. Jeffrey.plochocki@ucf.edu.; Department of Medical Education, University of Central Florida, College of Medicine, 6850 Lake Nona Blvd, Orlando, FL, 85308, USA. Jeffrey.plochocki@ucf.edu.

Publikováno v: BMC complementary and alternative medicine [BMC Complement Altern Med] 2019 Feb 04; Vol. 19 (1), pp. 39. Date of Electronic Publication: 2019 Feb 04.

Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.

Autor: Zinter MS; 1Division of Critical Care, Department of Pediatrics, UCSF School of Medicine, Benioff Children's Hospital, San Francisco, CA. 2Departments of Medicine and Anesthesia, UCSF School of Medicine, Cardiovascular Research Institute, San Francisco, CA. 3Division of Critical Care, Department of Pediatrics, UCLA Geffen School of Medicine, Mattel Children's Hospital, Los Angeles, CA., Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A

Publikováno v: Critical care medicine [Crit Care Med] 2017 May; Vol. 45 (5), pp. 858-866.