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Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics.

Autor: Jager SA; Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands., Shapovalova IV, Jekel PA, Alkema WB, Svedas VK, Janssen DB

Publikováno v: Journal of biotechnology [J Biotechnol] 2008 Jan 01; Vol. 133 (1), pp. 18-26. Date of Electronic Publication: 2007 Aug 30.

MSCAN: identification of functional clusters of transcription factor binding sites.

Autor: Alkema WB; Center for Genomics and Bioinformatics, Karolinska Institutet, SE-17177 Stockholm, Sweden., Johansson O, Lagergren J, Wasserman WW

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2004 Jul 01; Vol. 32 (Web Server issue), pp. W195-8.

Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.

Autor: Alkema WB; Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG, The Netherlands., Hensgens CM, Snijder HJ, Keizer E, Dijkstra BW, Janssen DB

Publikováno v: Protein engineering, design & selection : PEDS [Protein Eng Des Sel] 2004 May; Vol. 17 (5), pp. 473-80. Date of Electronic Publication: 2004 Jul 14.

Role of alphaArg145 and betaArg263 in the active site of penicillin acylase of Escherichia coli.

Autor: Alkema WB; Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands., Prins AK, de Vries E, Janssen DB

Publikováno v: The Biochemical journal [Biochem J] 2002 Jul 01; Vol. 365 (Pt 1), pp. 303-9.