Výsledky vyhledávání - "Alkeiver Cannon"

Akademický článek

Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs

Autor: Bryan Latrell Holloman, Kiesha Wilson, Alkeiver Cannon, Mitzi Nagarkatti, Prakash S. Nagarkatti

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionIndole-3-carbinol (I3C) is found in cruciferous vegetables and used as a dietary supplement. It is known to act as a ligand for aryl hydrocarbon receptor (AhR). In the current study, we investigated the role of AhR and the ability of I3C

Externí odkaz: https://doaj.org/article/4698350205fc4d7f82129aeec4a0a887

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Akademický článek

Aryl Hydrocarbon Receptor Activation Ameliorates Acute Respiratory Distress Syndrome through Regulation of Th17 and Th22 Cells in the Lungs

Autor: Bryan Latrell Holloman, Alkeiver Cannon, Kiesha Wilson, Prakash Nagarkatti, Mitzi Nagarkatti

Publikováno v: mBio, Vol 14, Iss 2 (2023)

ABSTRACT Acute respiratory distress syndrome (ARDS) is triggered by a variety of insults, including bacterial and viral infections, and this leads to high mortality. While the role of the aryl hydrocarbon receptor (AhR) in mucosal immunity is being i

Externí odkaz: https://doaj.org/article/dc872711a43549d0b68fa4c1b7eaf0f7

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Targeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases

Autor: Mitzi Nagarkatti, Prakash Nagarkatti, Alkeiver Cannon

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 288, p 288 (2022)
International Journal of Molecular Sciences

For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from consideration as a therapeutic approach due to the potential toxic effects of AhR ligands and the induction of the cytochrome P450 enzyme, Cyp1a1, following AhR activation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3fca9a114c0d1a137102a1a7d32004
https://www.mdpi.com/1422-0067/23/1/288

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