Výsledky vyhledávání - "Alka Raj, Pandey"

Akademický článek

A standardized extract of Coleus forskohlii root protects rats from ovariectomy-induced loss of bone mass and strength, and impaired bone material by osteogenic and anti-resorptive mechanisms

Autor: Chirag Kulkarni, Shivani Sharma, Konica Porwal, Swati Rajput, Sreyanko Sadhukhan, Vaishnavi Singh, Akanksha Singh, Sanjana Baranwal, Saroj Kumar, Aboli Girme, Alka Raj Pandey, Suriya Pratap Singh, Koneni V. Sashidhara, Navin Kumar, Lal Hingorani, Naibedya Chattopadhyay

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

IntroductionIn obese humans, Coleus forskohlii root extract (CF) protects against weight gain owing to the presence of forskolin, an adenylate cyclase (AC) activator. As AC increases intracellular cyclic adenosine monophosphate (cAMP) levels in osteo

Externí odkaz: https://doaj.org/article/295d04eac52e41c1bf0082aace7536a9

Zobrazit plný text záznamu

Antileishmanial evaluation of triazole–butenolide conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions

Autor: Alka Raj Pandey, Suriya Pratap Singh, Karthik Ramalingam, Kanchan Yadav, Amol Chhatrapati Bisen, Rabi Sankar Bhatta, Mrigank Srivastava, Renu Tripathi, Neena Goyal, Koneni V. Sashidhara

Publikováno v: RSC Medicinal Chemistry.

Synthesis of a novel series of 23 triazole–butenolide conjugates utilizing click chemistry and their antileishmanial, antimalarial, and antifilarial activity along with SAR, ADME predictions and pharmacokinetic study are discussed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85fb339c56ee833b9a1a6471d7170059
https://doi.org/10.1039/d2md00464j

Zobrazit plný text záznamu

Moringa oleifera impedes protein glycation and exerts reno-protective effects in streptozotocin-induced diabetic rats

Autor: Shadab Ahmad, Alka Raj Pandey, Amit K. Rai, Suriya P. Singh, Pawan Kumar, Sushmita Singh, Farah Gulzar, Ishbal Ahmad, Koneni V. Sashidhara, Akhilesh K. Tamrakar

Publikováno v: Journal of ethnopharmacology. 305

Moringa oleifera is a valued plant with wide distribution in tropical and subtropical regions of the world. It is traditionally used for the treatment of fever, infections, rheumatism, cancer, improving cardiac, renal and hepatic functions, and regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5c3aefb8d59d6e4a1876fc3b8d5ecf
https://pubmed.ncbi.nlm.nih.gov/36584917

Zobrazit plný text záznamu

Synthesis and Evaluation of Galloyl Conjugates of Flavanones as BMP-2 Upregulators with Promising Bone Anabolic and Fracture Healing Properties

Autor: Suriya P. Singh, Divya Rai, Alka Raj Pandey, Mohammad Imran Siddiqi, Alisha Ansari, Rabi Sankar Bhatta, Anjali Mishra, Ashish Kumar Tripathi, Naibedya Chattopadhyay, Ritu Trivedi, Anirban Sardar, Koneni V. Sashidhara, Sudha Bhagwati

Publikováno v: Journal of Medicinal Chemistry. 64:12487-12505

The molecular hybridization concept led us to design a series of galloyl conjugates of flavanones that have potent osteoblast differentiation ability in vitro and promote bone formation in vivo. An array of in vitro studies, especially gene expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9213af6cc29ca4ede7e8ea228202f0
https://doi.org/10.1021/acs.jmedchem.1c00112

Zobrazit plný text záznamu

A novel BMP2 secretagogue ameliorates glucocorticoid induced oxidative stress in osteoblasts by activating NRF2 dependent survival while promoting Wnt/β-catenin mediated osteogenesis

Autor: Divya Rai, Ashish Kumar Tripathi, Anirban Sardar, Alka Raj Pandey, Shradha Sinha, Kunal Chutani, Geeta Dhaniya, Priyanka Kothari, Koneni V. Sashidhara, Ritu Trivedi

Publikováno v: Free radical biologymedicine. 190

In our previous study, a novel BMP2 secretagogue was synthesized belonging to a class of galloyl conjugates of flavanones, with remarkable osteogenic potential that promoted bone regeneration. We aimed to establish the protective effect of our compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf4b0e920290e6f971db2f0d361f470
https://pubmed.ncbi.nlm.nih.gov/35963563

Zobrazit plný text záznamu

Furostanol saponins from Asparagus racemosus as potential hypoglycemic agents

Autor: Alka Raj Pandey, Shadab Ahmad, Suriya Pratap Singh, Anjali Mishra, Amol Chhatrapati Bisen, Gaurav Sharma, Ishbal Ahmad, Sanjeev K. Shukla, Rabi Sankar Bhatta, Sanjeev Kanojiya, Akhilesh Kumar Tamrakar, Koneni V. Sashidhara

Publikováno v: Phytochemistry. 201

Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877f19bbdbd173fcf5c2a5b254f1e740
https://pubmed.ncbi.nlm.nih.gov/35752344

Zobrazit plný text záznamu

Antiglycation activity of

Autor: Shadab, Ahmad, Alka Raj, Pandey, Suriya Pratap, Singh, Sushmita, Singh, Koneni V, Sashidhara, Akhilesh K, Tamrakar

Publikováno v: Natural product research. 36(24)

The increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in pathogenesis of various chronic ailments, including diabetes-associated secondary complications, atherosclerosis, aging, inflammatory and neurod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f14127f746e40ff85b899eb750595e1b
https://pubmed.ncbi.nlm.nih.gov/35021947

Zobrazit plný text záznamu

Antiglycation activity of β-glucogallin from Asparagus racemosus

Autor: Shadab Ahmad, Alka Raj Pandey, Suriya Pratap Singh, Sushmita Singh, Koneni V. Sashidhara, Akhilesh K. Tamrakar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6bb99ec07c3833d2cd3339c5e683e5

Zobrazit plný text záznamu

Flavonoids from Polyalthia longifolia prevents advanced glycation end products formation and protein oxidation aligned with fructose-induced protein glycation

Autor: Koneni V. Sashidhara, Alisha Ansari, Shadab Ahmad, Alka Raj Pandey, Amit K. Rai, Akhilesh K. Tamrakar, Suriya P. Singh

Publikováno v: Natural Product Research. 35:2921-2925

Advanced glycation end products (AGEs) are reactive chemical entities formed by non-enzymatic reaction between reducing sugars and amino group of proteins. Enhanced accumulation of AGEs and associa...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a149479aa057eca3f5c9e4fb658c69a4
https://doi.org/10.1080/14786419.2019.1672690

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání