Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alka A. Vyas"'
Publikováno v:
ResearcherID
Schwann cells in the distal stump of transected nerve upregulate growth factors that support regeneration on a modality-specific basis. It is unclear, however, which of these preferentially support motor axon regeneration. Identification of these fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121b74806c5de981ade1c20c79a69850
https://doi.org/10.1016/j.jneumeth.2014.05.005
https://doi.org/10.1016/j.jneumeth.2014.05.005
Autor:
Nicole Reed, Alka A. Vyas, Ahmet Hoke, Daniel H. Geschwind, Emmalynn Connor, Manula Alspalter, Ruifa Mi, Giovanni Coppola, Thomas M. Brushart, Megan C. Wright
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34, iss 5
Previous studies demonstrated that Schwann cells (SCs) express distinct motor and sensory phenotypes, which impact the ability of these pathways to selectively support regenerating neurons. In the present study, unbiased microarray analysis was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672cadd069f36bb37ecf030a44a3c757
https://doi.org/10.1523/jneurosci.3822-13.2014
https://doi.org/10.1523/jneurosci.3822-13.2014
Publikováno v:
Experimental Neurology. 249:1-7
Preferential motor reinnervation (PMR) is the tendency for motor axons regenerating after repair of mixed nerve to reinnervate muscle nerve and/or muscle rather than cutaneous nerve or skin. PMR may occur in response to the peripheral nerve pathway a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d646edd54c9952d1c78b328461cebb37
https://doi.org/10.1016/j.expneurol.2013.07.019
https://doi.org/10.1016/j.expneurol.2013.07.019
Publikováno v:
Journal of Biological Chemistry. 282:27875-27886
In the injured nervous system, myelin-associated glycoprotein (MAG) on residual myelin binds to receptors on axons, inhibits axon outgrowth, and limits functional recovery. Conflicting reports identify gangliosides (GD1a and GT1b) and glycosylphospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ad83b31c9295003057f8ed14cd285b
https://doi.org/10.1074/jbc.m704055200
https://doi.org/10.1074/jbc.m704055200
Publikováno v:
Journal of Biological Chemistry. 280:16305-16310
Myelin-associated glycoprotein (MAG, Siglec-4) is one of several endogenous axon regeneration inhibitors that limit recovery from central nervous system injury and disease. Molecules that block such inhibitors may enhance axon regeneration and functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b37311a76088ff22bc41fb3facf619
https://doi.org/10.1074/jbc.m500250200
https://doi.org/10.1074/jbc.m500250200
Autor:
Himatkumar V. Patel, Ronald L. Schnaar, Susan Fromholt, Alka A. Vyas, Kavita A. Vyas, Melitta Schachner, Jiyoung M. Dang, Marija Heffer-Lauc
Publikováno v:
Proceedings of the National Academy of Sciences. 99:8412-8417
Myelin-associated glycoprotein (MAG) binds to the nerve cell surface and inhibits nerve regeneration. The nerve cell surface ligand(s) for MAG are not established, although sialic acid-bearing glycans have been implicated. We identify the nerve cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018caee05547ba91ce422ab3ebdc9175
https://doi.org/10.1073/pnas.072211699
https://doi.org/10.1073/pnas.072211699
Autor:
Dawn M. Wayman, Hideharu Ishida, John W. Griffin, Wouter Laroy, Ronald L. Schnaar, Marija Heffer-Lauc, Alka A. Vyas, Kazim A. Shiekh, Hiromi Ito, Yanping Gong, Susan Fromholt, Makoto Kiso
Publikováno v:
Analytical Biochemistry. 302:276-284
Mice genetically engineered to lack complex gangliosides are improved hosts for raising antibodies against those gangliosides. We report the generation and characterization of nine immunoglobulin G (IgG)-class monoclonal antibodies (mAbs) raised agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c1de1b309c7393abd8b553b65b1b23
https://doi.org/10.1006/abio.2001.5540
https://doi.org/10.1006/abio.2001.5540
Autor:
Ronald L. Schnaar, Alka A. Vyas
Publikováno v:
Biochimie. 83:677-682
Gangliosides, sialylated glycosphingolipids which are the predominant glycans on vertebrate nerve cell surfaces, are emerging as components of membrane rafts, where they can mediate important physiological functions. Myelin associated glycoprotein (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bea815416c38ce8f0474db6abb589a3
https://doi.org/10.1016/s0300-9084(01)01308-6
https://doi.org/10.1016/s0300-9084(01)01308-6
Autor:
You Cheng Sheu, Wen-guey Wu, Himatkumar V. Patel, Jenn-Kang Hwang, Chien-Min Chiang, Jiann Jong Pan, Kavita A. Vyas, Alka A. Vyas
Publikováno v:
Journal of Biological Chemistry. 272:9661-9670
Heparin and heparan sulfate have recently been shown to bind to snake cardiotoxin (CTX) and to potentiate its penetration into phospholipid monolayer under physiological ionic conditions. Herein we analyze the heparin-binding domain of CTX using 10 C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1affff90d006acb4009775739472e92
https://doi.org/10.1074/jbc.272.15.9661
https://doi.org/10.1074/jbc.272.15.9661
Autor:
Lang Ming Chi, Chien-Min Chiang, Wen-guey Wu, Alka A. Vyas, Himatkumar V. Patel, Kavita A. Vyas, Yi Shiuan Liu
Publikováno v:
Journal of Biological Chemistry. 272:1484-1492
Cardiotoxins (CTXs) from cobra venom show cytotoxicity toward several cell types. They cause systolic heart arrest and severe tissue necrosis. Their interaction with phospholipids is established but by itself fails to explain the specificity of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37acda83fc3b02f6351b85e2f59699d4
https://doi.org/10.1074/jbc.272.3.1484
https://doi.org/10.1074/jbc.272.3.1484