Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Aljoscha Wahl"'
Publikováno v:
Metabolites, Vol 4, Iss 2, Pp 347-372 (2014)
Microorganisms are constantly exposed to rapidly changing conditions, under natural as well as industrial production scale environments, especially due to large-scale substrate mixing limitations. In this work, we present an experimental approach bas
Externí odkaz:
https://doaj.org/article/b58fe519be49418eab993fb800f96b61
Publikováno v:
Metabolites, Vol 4, Iss 2, Pp 281-299 (2014)
Pichia pastoris has been recognized as an effective host for recombinant protein production. In this work, we combine metabolomics and instationary 13C metabolic flux analysis (INST 13C-MFA) using GC-MS and LC-MS/MS to evaluate the potential impact o
Externí odkaz:
https://doaj.org/article/b0d08b55050740fe9820cbd3fd37a236
Publikováno v:
Metabolites, Vol 6, Iss 2, p 12 (2016)
Ammonium (NH4+) is the most common N-source for yeast fermentations, and N-limitation is frequently applied to reduce growth and increase product yields. While there is significant molecular knowledge on NH4+ transport and assimilation, there have be
Externí odkaz:
https://doaj.org/article/7ff566c719f0412da5b083c560b1e946
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 4, Pp 629-639 (2023)
Utilizing anaerobic metabolisms for the production of biotechnologically relevant products presents potential advantages, such as increased yields and reduced energy dissipation. However, lower energy dissipation may indicate that certain reactions a
Externí odkaz:
https://doaj.org/article/8c93bb8f0b5546ce9c848669f4f450e7
Autor:
Joan Sebastián Gallego-Murillo, Nurcan Yağcı, Eduardo Machado Pinho, Sebastian Aljoscha Wahl, Emile van den Akker, Marieke von Lindern
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Iron, supplemented as iron-loaded transferrin (holotransferrin), is an essential nutrient in mammalian cell cultures, particularly for erythroid cultures. The high cost of human transferrin represents a challenge for large scale production o
Externí odkaz:
https://doaj.org/article/9aa35987239441b981f2fef086726568
Autor:
Carla Inês Soares Rodrigues, Maxime den Ridder, Martin Pabst, Andreas K. Gombert, Sebastian Aljoscha Wahl
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Both the identity and the amount of a carbon source present in laboratory or industrial cultivation media have major impacts on the growth and physiology of a microbial species. In the case of the yeast Saccharomyces cerevisiae, sucrose is a
Externí odkaz:
https://doaj.org/article/d5073d0320884bfbbf134e3cfe2d1638
Autor:
Karel Olavarria, Yared O. Pijman, Ricardo Cabrera, Mark C. M. van Loosdrecht, S. Aljoscha Wahl
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The coupling of PHB generation with NADH reoxidation is required to generate PHB as a fermentation product. A fundamental trait to accomplish this feature is to express a functional NADH-preferring acetoacetyl-CoA reductase, engaged in PHB a
Externí odkaz:
https://doaj.org/article/488e8e01839d4771acfc70f5de3ccfb1
Autor:
David Lao-Martil, Koen J. A. Verhagen, Ana H. Valdeira Caetano, Ilse H. Pardijs, Natal A. W. van Riel, S. Aljoscha Wahl
Publikováno v:
Metabolites, Vol 13, Iss 1, p 88 (2023)
Microbial metabolism is strongly dependent on the environmental conditions. While these can be well controlled under laboratory conditions, large-scale bioreactors are characterized by inhomogeneities and consequently dynamic conditions for the organ
Externí odkaz:
https://doaj.org/article/3a62b617fbb6469797c7fc99152a0a72
Autor:
David Lao-Martil, Koen J. A. Verhagen, Joep P. J. Schmitz, Bas Teusink, S. Aljoscha Wahl, Natal A. W. van Riel
Publikováno v:
Metabolites, Vol 12, Iss 1, p 74 (2022)
Central carbon metabolism comprises the metabolic pathways in the cell that process nutrients into energy, building blocks and byproducts. To unravel the regulation of this network upon glucose perturbation, several metabolic models have been develop
Externí odkaz:
https://doaj.org/article/1359d294128b492c8b2aa93b12a75af8
Autor:
Carla Inês Soares Rodrigues, Maxime den Ridder, Martin Pabst, Andreas K. Gombert, Sebastian Aljoscha Wahl
Both the identity and the amount of a carbon source present in laboratory or industrial cultivation media have major impacts on the growth and physiology of a microbial species. In the case of the yeastSaccharomyces cerevisiae, sucrose is arguably th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a31cdbfcbd04ca7bb9994d80be827d49
https://doi.org/10.1101/2022.11.03.515096
https://doi.org/10.1101/2022.11.03.515096
