Výsledky vyhledávání - "Aljona Borschewski"

Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms

Autor: Sebastian Bachmann, Michael Bader, Robert Labes, Kerim Mutig, James A. McCormick, Alexander Paliege, Aljona Borschewski, Christin Boldt, David H. Ellison, Katharina I. Blankenstein

Publikováno v: American Journal of Physiology-Renal Physiology. 312:F489-F501

Calcineurin dephosphorylates nuclear factor of activated T cells transcription factors, thereby facilitating T cell-mediated immune responses. Calcineurin inhibitors are instrumental for immunosuppression after organ transplantation but may cause sid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6284c4bba184d5a0a1011607e898e66
https://doi.org/10.1152/ajprenal.00575.2016

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Demonstration of the functional impact of vasopressin signaling in the thick ascending limb by a targeted transgenic rat approach

Autor: Sebastian Bachmann, Michael Bader, Elena Popova, Christin Boldt, Kerim Mutig, Aljona Borschewski, Alexander Paliege, Tordis Borowski

Publikováno v: American Journal of Physiology-Renal Physiology. 311:F411-F423

The antidiuretic hormone vasopressin (AVP) regulates renal salt and water reabsorption along the distal nephron and collecting duct system. These effects are mediated by vasopressin 2 receptors (V2R) and release of intracellular Gs-mediated cAMP to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf73d97ee77273b0b89abcdfe51de5bf
https://doi.org/10.1152/ajprenal.00126.2016

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Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na+-K+-2Cl− Cotransporter

Autor: Nina Himmerkus, Sebastian Bachmann, David H. Ellison, Vera Jankowski, Thomas E. Willnow, Markus Bleich, Rebecca A. Lazelle, Allein Plain, Kerim Mutig, James A. McCormick, Katharina I. Blankenstein, Christin Boldt, Aljona Borschewski

Publikováno v: Journal of the American Society of Nephrology. 27:107-119

The furosemide-sensitive Na+-K+-2Cl(-)-cotransporter (NKCC2) is crucial for NaCl reabsorption in kidney thick ascending limb (TAL) and drives the urine concentrating mechanism. NKCC2 activity is modulated by N-terminal phosphorylation and dephosphory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162d5bb055f3489b5dda24450ecbae6b
https://doi.org/10.1681/asn.2014070728

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Caveolin 1 Promotes Renal Water and Salt Reabsorption

Autor: Carsten Dittmayer, Sebastian Bachmann, Markus Schuelke, Andreas Patzak, Yan Willière, Aljona Borschewski, Kerim Mutig, Tatiana Nikitina, Anna L. Daigeler

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Caveolin-1 (Cav1) is essential for the formation of caveolae. Little is known about their functional role in the kidney. We tested the hypothesis that caveolae modulate renal salt and water reabsorption. Wild-type (WT) and Cav1-deficient (Cav1−/−

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0509af49b1da31ba9e81ac8a2e19a505
https://pubmed.ncbi.nlm.nih.gov/29323234

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Molecular Analysis of Varicella Vaccines and Varicella-Zoster Virus from Vaccine-Related Skin Lesions

Autor: Sebastian Voigt, Bernhard Ehlers, Aljona Borschewski, Judit Küchler, Sonja Thiele, Marc Bieberbach

Publikováno v: Clinical and Vaccine Immunology. 18:1058-1066

To prevent complications that might follow an infection with varicella-zoster virus (VZV), the live attenuated Oka strain (V-Oka) is administered to children in many developed countries. Three vaccine brands (Varivax from Sanofi Pasteur MSD; Varilrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a51bcb54e6c8515a2000ac8a1a7042
https://doi.org/10.1128/cvi.05021-11

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Calcineurin signalling in the thick ascending limb of the kidney (892.30)

Autor: Kerim Mutig, Rebecca A. Lazelle, James A. McCormick, Sebastian Bachmann, Thomas E. Willnow, Christin Dathe, Susanne Mathia, David H. Ellison, Vera Jankowski, Christian Rosenberger, Aljona Borschewski

Publikováno v: The FASEB Journal. 28

The calcineurin inhibitors cyclosporine and tacrolimus are widely used for immunosuppressive therapy but hypertension and electrolyte disorders often complicate their application. Hypertension duri...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9fe26bb4002517c816b3de583fc4db2
https://doi.org/10.1096/fasebj.28.1_supplement.892.30

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