Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism

Autor: Ladiwala, Pranay, Cai, Xiangchen, Naik, Harnish Mukesh, Aliyu, Lateef, Schilling, Martin, Antoniewicz, Maciek R., Betenbaugh, Michael J.

Publikováno v: In Metabolic Engineering September 2024 85:105-115

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Application of the CRISPR/Cas9 Gene Editing Method for Modulating Antibody Fucosylation in CHO Cells.

Autor: Wang Q; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Aliyu L; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Chung CY; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Rosenberg JN; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Yu G; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Betenbaugh MJ; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA. beten@jhu.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2810, pp. 249-271.