Are Tangles as Toxic as They Look?

Autor: Bradley T. Hyman, Alix de Calignon, Robert M. Koffie, Tara L. Spires-Jones, Katherine J. Kopeikina

Publikováno v: Spires-Jones, T L, Kopeikina, K J, Koffie, R M, de Calignon, A & Hyman, B T 2011, ' Are tangles as toxic as they look? ', Journal of Molecular Neuroscience, vol. 45, no. 3, pp. 438-44 . https://doi.org/10.1007/s12031-011-9566-7

Neurofibrillary tangles are intracellular accumulations of hyperphosphorylated and misfolded tau protein characteristic of Alzheimer's disease and other tauopathies. Classic cross-sectional studies of Alzheimer patient brains showed associations of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2aed52fb64db492ba7803632c7d0751
https://doi.org/10.1007/s12031-011-9566-7

Reversal of Neurofibrillary Tangles and Tau-Associated Phenotype in the rTgTauEC Model of Early Alzheimer's Disease

Autor: Alix de Calignon, Manuela Polydoro, Kevin R Kay, Allyson D. Roe, Rose Pitstick, Marc Suárez-Calvet, Laura Sanchez, Bradley T. Hyman, George A. Carlson, Teresa Gomez-Isla, Tara L. Spires-Jones, Samantha B. Nicholls

Publikováno v: Polydoro, M, de Calignon, A, Suárez-Calvet, M, Sanchez, L, Kay, K R, Nicholls, S B, Roe, A D, Pitstick, R, Carlson, G A, Gómez-Isla, T, Spires-Jones, T L & Hyman, B T 2013, ' Reversal of Neurofibrillary Tangles and Tau-Associated Phenotype in the rTgTauEC Model of Early Alzheimer's Disease ', Journal of Neuroscience, vol. 33, no. 33, pp. 13300-11 . https://doi.org/10.1523/JNEUROSCI.0881-13.2013
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Neurofibrillary tangles (NFTs), a marker of neuronal alterations in Alzheimer's disease (AD) and other tauopathies, are comprised of aggregates of hyperphosphorylated tau protein. We recently studied the formation of NFTs in the entorhinal cortex (EC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793a16c14baf826dd807e7174b4ae101
https://www.pure.ed.ac.uk/ws/files/13530721/Reversal_of_Neurofibrillary_Tangles_and_Tau_Associated_Phenotype_in_the_rTgTauEC_Model_of_Early_Alzheimer_s_Disease.pdf

Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging

Autor: Alix de Calignon, Bradley T. Hyman, Melanie Meyer-Luehmann, Brian J. Bacskai, Tara L. Spires-Jones

Publikováno v: Spires-Jones, T L, de Calignon, A, Meyer-Luehmann, M, Bacskai, B J & Hyman, B T 2011, ' Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging ', Methods, vol. 53, no. 3, pp. 201-7 . https://doi.org/10.1016/j.ymeth.2010.12.009

Aggregation of amyloid beta peptide into senile plaques and hyperphosphorylated tau protein into neurofibrillary tangles in the brain are the pathological hallmarks of Alzheimer's disease. Despite over a century of research into these lesions, the ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2900bcc96823b1cb95fa19d078c3d0b5
https://www.pure.ed.ac.uk/ws/files/11939056/Monitoring_protein_aggregation_and_toxicity_in_Alzheimer_s_disease_mouse_models_using_in_vivo_imaging.pdf

Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy

Autor: Rose Pitstick, Bradley T. Hyman, George A. Carlson, Alix de Calignon, Tara L. Spires-Jones

Publikováno v: de Calignon, A, Spires-Jones, T L, Pitstick, R, Carlson, G A & Hyman, B T 2009, ' Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy ', Journal of Neuropathology and Experimental Neurology, vol. 68, no. 7, pp. 757-61 . https://doi.org/10.1097/NEN.0b013e3181a9fc66

Neurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear. We studied cell death in Tg4510 mice that reversibly express P301L muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54be06119e30a42e691c1a1369976bdd
https://europepmc.org/articles/PMC2756569/

Tau pathophysiology in neurodegeneration: a tangled issue

Autor: Alix de Calignon, Phillip B. Jones, William H. Stoothoff, Tara L. Spires-Jones, Bradley T. Hyman

Publikováno v: Trends in neurosciences. 32(3)

Neurodegenerative tauopathies are marked by their common pathologic feature of aggregates formed of hyperphosphorylated tau protein, which are associated with synapse and neuronal loss. Changes in tau conformation result in both loss of normal functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cec14a86ee533f8971111f62c359e73
https://pubmed.ncbi.nlm.nih.gov/19162340