Endoscopic ultrasound-guided fine-needle aspiration plus KRAS and GNAS mutation in malignant intraductal papillary mucinous neoplasm of the pancreas

Autor: Barbara Bournet, Alix Vignolle-Vidoni, David Grand, Céline Roques, Florence Breibach, Jérome Cros, Fabrice Muscari, Nicolas Carrère, Janick Selves, Pierre Cordelier, Louis Buscail

Publikováno v: Endoscopy International Open, Vol 04, Iss 12, Pp E1228-E1235 (2016)

Background: KRAS and GNAS mutations are common in intraductal papillary mucinous neoplasia of the pancreas (IPMN). The aims of this study were to assess the role of pre-therapeutic cytopathology combined with KRAS and GNAS mutation assays within cyst

Externí odkaz: https://doaj.org/article/7586aadef93c4cc99900377f27979cf3

First-in-man Phase 1 Clinical Trial of Gene Therapy for Advanced Pancreatic Cancer: Safety, Biodistribution, and Preliminary Clinical Findings

Autor: Fabienne Vernejoul, Gérard Tiraby, Frédéric Martins, Naïma Hanoun, Laetitia Ligat, Hubert Lulka, Pierre Cordelier, Barbara Bournet, Aline Meulle, Sébastien Déjean, Odile Barbey, Rosine Guimbaud, Marion Gayral, Gilles Cambois, Marlène Dufresne, Philippe Otal, Louis Buscail, Fabian Gross, Frédéric Lopez, Frédéric Pont, Jérôme Torrisani, Nathalie Saint-Laurent, Alix Vignolle-Vidoni

Publikováno v: Molecular Therapy
Molecular Therapy, Nature Publishing Group, 2015, 23 (4), pp.779-789. ⟨10.1038/mt.2015.1⟩
Molecular Therapy, Cell Press, 2015, 23 (4), pp.779-789. ⟨10.1038/mt.2015.1⟩
Molecular Therapy, 2015, 23 (4), pp.779-789. ⟨10.1038/mt.2015.1⟩

This phase 1 trial was aimed to determine the safety, pharmacokinetics, and preliminary clinical activity of CYL-02, a nonviral gene therapy product that sensitizes pancreatic cancer cells to chemotherapy. CYL-02 was administrated using endoscopic ul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0e64ca922749e83e2cb7778a98c272

Endoscopic ultrasound-guided fine-needle aspiration plus KRAS and GNAS mutation in malignant intraductal papillary mucinous neoplasm of the pancreas

Autor: Pierre Cordelier, Alix Vignolle-Vidoni, Florence Breibach, Nicolas Carrere, Janick Selves, Céline Roques, Jérôme Cros, Fabrice Muscari, Barbara Bournet, Louis Buscail, David Grand

Publikováno v: Endoscopy International Open, Vol 04, Iss 12, Pp E1228-E1235 (2016)
Endoscopy International Open

Background: KRAS and GNAS mutations are common in intraductal papillary mucinous neoplasia of the pancreas (IPMN). The aims of this study were to assess the role of pre-therapeutic cytopathology combined with KRAS and GNAS mutation assays within cyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2306e98770eefe82ee2b4695a389c6
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-117216

Targeted oncolytic herpes simplex virus type 1 eradicates experimental pancreatic tumors

Autor: Alberto L. Epstein, Naïma Hanoun, Coline Biollay, Hubert Lulka, Jean-Luc Béjot, Louis Buscail, Alix Vignolle-Vidoni, Pierre Cordelier, Pascal Trempat, Herve Berthomme, Marion Gayral, Janick Selves

Publikováno v: Human gene therapy. 26(2)

As many other cancers, pancreatic ductal adenocarcinoma (PDAC) progression is associated with a series of hallmark changes for cancer cells to secure their own growth success. Yet, these very changes render cancer cells highly sensitive to viral infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a94a4c645cf00076e4d182a1f8547e0
https://pubmed.ncbi.nlm.nih.gov/25423447

Abstract B96: Non-viral gene therapy for pancreatic cancer, from preclinical models to phase II clinical trial

Autor: Gilles Cambois, Fabienne Vernejoul, Naïma Hanoun, Louis Buscail, Rosine Guimbaud, Aline Meulle, Alix Vignolle-Vidoni, Barbara Bournet, Fabian Gross, Pierre Cordelier, Gérard Tiraby, Odile Barbey, Philippe Ottal, Hubert Lulka

Publikováno v: Cancer Research. 75:B96-B96

To date, pancreatic adenocarcinoma (PDAC) can’t be diagnosed early. Consequently, a majority of patient (80%) display an advanced disease that results in a low resection rate leading to a dismal overall median survival of less than 6 months. We ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::205a5a7887f7e2684e07bf6be9025c94
https://doi.org/10.1158/1538-7445.panca2014-b96