Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Alistair Mathie"'
Autor:
Margot A. Cousin, Emma L. Veale, Nikita R. Dsouza, Swarnendu Tripathi, Robyn G. Holden, Maria Arelin, Geoffrey Beek, Mir Reza Bekheirnia, Jasmin Beygo, Vikas Bhambhani, Martin Bialer, Stefania Bigoni, Cyrus Boelman, Jenny Carmichael, Thomas Courtin, Benjamin Cogne, Ivana Dabaj, Diane Doummar, Laura Fazilleau, Alessandra Ferlini, Ralitza H. Gavrilova, John M. Graham, Tobias B. Haack, Jane Juusola, Sarina G. Kant, Saima Kayani, Boris Keren, Petra Ketteler, Chiara Klöckner, Tamara T. Koopmann, Teresa M. Kruisselbrink, Alma Kuechler, Laëtitia Lambert, Xénia Latypova, Robert Roger Lebel, Magalie S. Leduc, Emanuela Leonardi, Andrea M. Lewis, Wendy Liew, Keren Machol, Samir Mardini, Kirsty McWalter, Cyril Mignot, Julie McLaughlin, Alessandra Murgia, Vinodh Narayanan, Caroline Nava, Sonja Neuser, Mathilde Nizon, Davide Ognibene, Joohyun Park, Konrad Platzer, Céline Poirsier, Maximilian Radtke, Keri Ramsey, Cassandra K. Runke, Maria J. Guillen Sacoto, Fernando Scaglia, Marwan Shinawi, Stephanie Spranger, Ee Shien Tan, John Taylor, Anne-Sophie Trentesaux, Filippo Vairo, Rebecca Willaert, Neda Zadeh, Raul Urrutia, Dusica Babovic-Vuksanovic, Michael T. Zimmermann, Alistair Mathie, Eric W. Klee
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-19 (2022)
Abstract Background Genomics enables individualized diagnosis and treatment, but large challenges remain to functionally interpret rare variants. To date, only one causative variant has been described for KCNK9 imprinting syndrome (KIS). The genotypi
Externí odkaz:
https://doaj.org/article/e3306fa1990545148f66b913263d56ba
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Objective: Numerous pathogenic variants in KCNB1, which encodes the voltage-gated potassium channel, KV2.1, are linked to developmental and epileptic encephalopathies and associated with loss-of-function, -regulation, and -expression of the channel.
Externí odkaz:
https://doaj.org/article/48d5df39250d4195bac5fee05793b7ee
Autor:
Tatjana Lalic, Aiste Steponenaite, Liting Wei, Sridhar R. Vasudevan, Alistair Mathie, Stuart N. Peirson, Gurprit S. Lall, M. Zameel Cader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state
Externí odkaz:
https://doaj.org/article/92d80056b5bc4ccbb603e1addb6b05b5
Publikováno v:
Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 101021- (2021)
TREK and TRESK K2P channels are widely expressed in the nervous system, particularly in sensory neurons, where they regulate neuronal excitability. In this study, using whole-cell patch-clamp electrophysiology, we characterise the inhibitory effect o
Externí odkaz:
https://doaj.org/article/4f921aa9afae4c03aa88615f89c1e064
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Pulmonary arterial hypertension (PAH) is an aggressive vascular remodeling disease that carries a high morbidity and mortality rate. Treprostinil (Remodulin) is a stable prostacyclin analogue with potent vasodilatory and anti-proliferative activity,
Externí odkaz:
https://doaj.org/article/dae73fd34d874cd3b61b18fba329d3e3
Autor:
Sandra Medrano-Garcia, Daniel Morales-Cano, Bianca Barreira, Alba Vera-Zambrano, Rahul Kumar, Djuro Kosanovic, Ralph Theo Schermuly, Brian B. Graham, Francisco Perez-Vizcaino, Alistair Mathie, Rajkumar Savai, Soni Pullamseti, Ghazwan Butrous, Edgar Fernández-Malavé, Angel Cogolludo
Publikováno v:
Cells, Vol 11, Iss 15, p 2414 (2022)
HIV and Schistosoma infections have been individually associated with pulmonary vascular disease. Co-infection with these pathogens is very common in tropical areas, with an estimate of six million people co-infected worldwide. However, the effects o
Externí odkaz:
https://doaj.org/article/ea63a3af06fc4a9ead50b0c65617d7ab
Autor:
Vilius Savickas, Adrian J Stewart, Melanie Rees-Roberts, Vanessa Short, Sukvinder K Bhamra, Sarah A Corlett, Alistair Mathie, Emma L Veale
Publikováno v:
PLoS Medicine, Vol 17, Iss 7, p e1003197 (2020)
BackgroundGrowing prevalence of atrial fibrillation (AF) in the ageing population and its associated life-changing health and resource implications have led to a need to improve its early detection. Primary care is an ideal place to screen for AF; ho
Externí odkaz:
https://doaj.org/article/ad280f059d3a48bcb6089dcc8b246244
Autor:
Vilius Savickas, Emma L Veale, Sukvinder K Bhamra, Adrian J Stewart, Alistair Mathie, Sarah Corlett
Publikováno v:
BJGP Open, Vol 4, Iss 3 (2020)
Background: Atrial fibrillation (AF) affects up to 10% of people aged ≥65 years, yet a third of all cases remain undetected. Practice-based pharmacists are in an ideal position to facilitate opportunistic AF screening, while increasing general prac
Externí odkaz:
https://doaj.org/article/303f3aa60e404614b0a73bae6a4e3e8a
Autor:
Diego Fernández-Fernández, Alba Cadaveira-Mosquera, Lola Rueda-Ruzafa, Salvador Herrera-Pérez, Emma L Veale, Antonio Reboreda, Alistair Mathie, J Antonio Lamas
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199282 (2018)
Two-pore domain potassium channels (K2P) constitute major candidates for the regulation of background potassium currents in mammalian cells. Channels of the TREK subfamily are also well positioned to play an important role in sensory transduction due
Externí odkaz:
https://doaj.org/article/99f52cef04d7426eaeae18e1c4931dc6
Publikováno v:
Frontiers in pharmacology. 13