Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alissa Trzeciak"'
Autor:
Alissa Trzeciak, Raj Kumar Mongre, Ma Rie Kim, Kihong Lim, Rafael A. Madero, Christopher N. Parkhurst, Anthony P. Pietropaoli, Minsoo Kim
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sepsis is a life-threatening systemic inflammatory condition causing approximately 11 million annual deaths worldwide. Although key hyperinflammation-based organ dysfunctions that drive disease pathology have been recognized, our understanding of the
Externí odkaz:
https://doaj.org/article/f4fc9b38ae7c4c05956a1183de6570d8
Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
Autor:
Jiqiang Lin, Lu Yang, Hernandez Moura Silva, Alissa Trzeciak, Yongwon Choi, Susan R. Schwab, Michael L. Dustin, Juan J. Lafaille
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue
Externí odkaz:
https://doaj.org/article/0e0b6c0f56ef4a0d8b0da62b638522a4
Autor:
Justin Perry, Alissa Trzeciak, Waleska Saitz Rojas, Adam Krebs, Giulia Zago, Ya-Ting Wang, Zhaoquan Wang, Pedro Saavedra, Jian Xie, Chou-Long Huang, Michael Overholtzer, Michael Glickman, Christopher Parkhurst, Thomas Vierbuchen, Christopher Lucas
The appropriate development of myeloid progenitors into macrophages, the body’s professional phagocyte, is essential for organismal development, especially in mammals1. This dependence is exemplified by the observation that loss-of-function mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b849bf3b9f52f7367b2767fc1e988c95
https://doi.org/10.21203/rs.3.rs-1344322/v1
https://doi.org/10.21203/rs.3.rs-1344322/v1
Autor:
Pedro H. V. Saavedra, Alissa Trzeciak, Zhaoquan Wang, Waleska Saitz Rojas, Giulia Zago, Melissa D. Docampo, Jacob G. Verter, Marcel R. M. van den Brink, Christopher D. Lucas, Christopher J. Anderson, Alexander Y. Rudensky, Justin S. A. Perry
The phagocytic clearance of dying cells, termed efferocytosis, is essential for both tissue homeostasis and tissue health during cell death-inducing treatments. Failure to efficiently clear dying cells augments the risk of pathological inflammation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f88d8bbaea31816b390ff1793ac56b0
https://doi.org/10.1101/2022.08.17.504322
https://doi.org/10.1101/2022.08.17.504322
Autor:
Ya-Ting Wang, Alissa Trzeciak, Waleska Saitz Rojas, Pedro Saavedra, Yan-Ting Chen, Rachel Chirayil, Jon Iker Etchegaray, Christopher D. Lucas, Daniel J. Puleston, Kayvan R. Keshari, Justin S. A. Perry
SummaryApoptotic cell clearance (efferocytosis), a process essential for organismal homeostasis, is performed by phagocytes that inhabit a wide range of environments, including physiologic hypoxia. Here, we find macrophages, the predominant tissue-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b3abe2ffec01f183d10e0d9ca53b00
https://doi.org/10.1101/2022.08.04.502838
https://doi.org/10.1101/2022.08.04.502838
Autor:
Alissa Trzeciak, Yelena V. Lerman, Marc W. Halterman, Ma Rie Kim, Nguyen Mai, Tae-Hyoun Kim, Minsoo Kim
Publikováno v:
J Immunol
Severe sepsis, a systemic inflammatory response to infection, is an increasing cause of morbidity in intensive care units. During sepsis, the vasculature is profoundly altered, leading to release of microbial virulence factors and proinflammatory med
Publikováno v:
Cell Metab
Clearance of apoptotic cells, or ‘efferocytosis’, is essential for diverse processes including embryonic development, tissue turnover, organ regeneration, and immune cell development. The human body is estimated to remove approximately 1% of its
Biomarkers and Associated Immune Mechanisms for Early Detection and Therapeutic Management of Sepsis
Publikováno v:
Immune Network
Sepsis is conceptually defined as life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Although there has been significant advancement in recent decades in defining and understanding sepsis pathology, clinic
Autor:
Pranita P. Sarangi, Alissa Trzeciak, Eric J. Harrower, Hyunwook Lee, Alireza R. Rezaie, Yelena V. Lerman, Minsoo Kim
Publikováno v:
The Journal of Immunology. 199:2930-2936
The host injury involved in multiorgan system failure during severe inflammation is mediated, in part, by massive infiltration and sequestration of hyperactive neutrophils in the visceral organ. A recombinant form of human activated protein C (rhAPC)
Autor:
Alissa Trzeciak, Hen Prizant, Kihong Lim, Deborah J. Fowell, Tae-Hyoun Kim, Minsoo Kim, David J. Topham, Emma C. Reilly, Andrea Amitrano
Publikováno v:
Nat Immunol
Early recruitment of neutrophils from the blood to sites of tissue infection is a hallmark of innate immune responses. However, little is known about the mechanisms by which apoptotic neutrophils are cleared in infected tissues during resolution and