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pro vyhledávání: '"Alissa N. Novak"'
Autor:
Olha Melnyk, Charanya Muralidharan, Bryce E. Duffett, Alissa N. Novak, Glorian Perez-Aviles, Michelle M. Martinez, Justin J. Crowder, Amelia K. Linnemann
The catabolic pathway of autophagy is critical for pancreatic beta-cell function and is defective in established type 1 diabetes (T1D). However, it is unclear when and how this critical cell process becomes defective during diabetes pathogenesis. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db9b65f7443fbb1bfea9dca85e12eb5
https://doi.org/10.1101/2023.05.23.541935
https://doi.org/10.1101/2023.05.23.541935
Publikováno v:
Proceedings of IMPRS. 5
Background and Hypothesis: It has been demonstrated that the protective degradative process of autophagy is defective in the context of human T1D. Additionally, a type I interferon-inducible transcriptional signature has been detected in blood cells
Publikováno v:
Islets. 14:128-138
Metabolic dysfunction of β-cells has been implicated as a contributor to diabetes pathogenesis, and efforts are ongoing to optimize analytical techniques that evaluate islet metabolism. High-resolution respirometry offers sensitive measurements of t
Autor:
Anish P. Patel, Alissa N. Novak, Tanmaye N. Chakravarthula, Nathan J. Alves, Amelia K. Linnemann
Publikováno v:
Proceedings of IMPRS. 4
Background and Hypothesis: Type 1 Diabetes (T1D) is a progressive disease in which the insulin-producing beta-cells of the pancreas are damaged by autoimmune attack, often associated with accumulation of reactive oxygen species (ROS) in the early pat