Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alissa M. Wong"'
Autor:
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES.
Major genomic drivers of hepatocellular carcinoma (HCC) are nowadays well recognized, although models to establish their roles in human HCC initiation remain scarce. Here, we used human liver organoids in experimental systems to mimic the early stage
Publikováno v:
Cancer Research. 83:3959-3959
The Ubiquitin-Proteasome System (UPS) is the major pathway in eukaryotic cells that regulates intracellular protein degradation and turnover. Cumulative evidence has suggested that defects in the UPS machinery are involved in the pathogenesis of huma
Publikováno v:
Cancer Research. 83:3987-3987
Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, has an overall 5-year survival rate of around 20%, making it the third leading cause of cancer-related death worldwide. Upregulated nucleotide metabolism is frequently iden
Autor:
Mingjing Xu, Yue Liu, Ho Lee Wan, Alissa M. Wong, Xiaofan Ding, Wenxing You, Wing Sze Lo, Kelvin K-C Ng, Nathalie Wong
Publikováno v:
Cancer letters. 548
Uracil misincorporation during DNA replication is a major cell toxic event, of which cancer cells overcome by activating the dUTPase enzyme. The DUT gene is the only known dUTPase in human. Despite reports on common upregulations in cancers, the role
Autor:
Nathalie Wong, Chit Chow, Aden K-Y. Chan, James Y.W. Lau, Paul A. Johnston, Herbert H. Loong, Xiaofan Ding, Maggie Cheung, Danny T-M. Chan, Wai Sang Poon, Alissa M. Wong
Publikováno v:
Journal of Clinical Neuroscience. 78:400-402
Despite significant medical advances, glioblastoma multiforme (GBM) remains a formidable therapeutic challenge. Advent of targeted capture sequencing and patients-derived organoid cultures may hold the key to scientifically sound individualized treat
Autor:
Maggie M. T. Wong, Helena Lam, Matthew K.H. Man, Paul A. Johnston, Zhe Zhang, Hui Chen, Aikha M. Wong, Paul B.S. Lai, Alissa M. Wong, Winnie K. Cheung, David A Close, Anthony T.C. Chan, Joseph Kwong, Nathalie Wong
Publikováno v:
Cancer Research. 80:3911-3911
Current in vitro models of primary liver cancer insufficiently recapitulates the tumor heterogeneity and pathophysiology of the original patient's tumor. This significantly hinders translational studies and often leads to the high rate of clinical tr
Autor:
Ka Fai To, Arthur K.K. Ching, Anthony W.H. Chan, Tingting Sun, Mian He, Ngai Na Co, Henry Lik-Yuen Chan, Nathalie Wong, Paul B.S. Lai, Chi-Chiu Lau, Jing-Woei Li, Joanna H.M. Tong, Alissa M. Wong, Ting-Fung Chan, Raymond W.M. Lung, Pik-Shan Li
Publikováno v:
Cancer cell. 25(3)
SummaryThe mutagenic effect of hepatitis B (HBV) integration in predisposing risk to hepatocellular carcinoma (HCC) remains elusive. In this study, we performed transcriptome sequencing of HBV-positive HCC cell lines and showed transcription of viral