Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Alissa M. Weaver"'
Autor:
Hannah Nelson, Sherman Qu, Jeffrey L. Franklin, Qi Liu, Heather H. Pua, Kasey C. Vickers, Alissa M. Weaver, Robert J. Coffey, James G. Patton
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 17-31 (2024)
Extracellular vesicles and nanoparticles (EVPs) are now recognized as a novel form of cell–cell communication. All cells release a wide array of heterogeneous EVPs with distinct protein, lipid, and RNA content, dependent on the pathophysiological s
Externí odkaz:
https://doaj.org/article/0149ce03e8b64eb8b051c0b241d31077
5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles
Autor:
Shimian Qu, Hannah M. Nelson, Xiao Liu, Yu Wang, Elizabeth M. Semler, Danielle L. Michell, Clark Massick, Jeffrey L. Franklin, John Karijolich, Alissa M. Weaver, Robert J. Coffey, Qi Liu, Kasey C. Vickers, James G. Patton
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 9, Pp n/a-n/a (2024)
Abstract 5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair.
Externí odkaz:
https://doaj.org/article/6e5702c671f04d8e9a2013298d18c044
Autor:
Lizandra Jimenez, Bahnisikha Barman, Youn Jae Jung, Lauren Cocozza, Evan Krystofiak, Cherie Saffold, Kasey C. Vickers, John T. Wilson, T. Renee Dawson, Alissa M. Weaver
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 11, Pp n/a-n/a (2023)
Abstract Extracellular vesicle (EV)‐carried miRNAs can influence gene expression and functional phenotypes in recipient cells. Argonaute 2 (Ago2) is a key miRNA‐binding protein that has been identified in EVs and could influence RNA silencing. Ho
Externí odkaz:
https://doaj.org/article/535c494cfba140799d73ec352ef56d94
Publikováno v:
Contact, Vol 5 (2022)
The mechanisms by which cytoplasmic cargoes such as RNAs are incorporated into extracellular vesicles (EVs) are poorly understood. In a recent article published in Developmental Cell, we describe a novel function of endoplasmic reticulum membrane con
Externí odkaz:
https://doaj.org/article/ca25e5da4e294805827df23d1aa32194
Autor:
Wanessa F. Altei, Bianca C. Pachane, Patty K. dos Santos, Lígia N. M. Ribeiro, Bong Hwan Sung, Alissa M. Weaver, Heloisa S. Selistre-de-Araújo
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background Extracellular vesicles (EVs) are lipid-bound particles that are naturally released from cells and mediate cell-cell communication. Integrin adhesion receptors are enriched in small EVs (SEVs) and SEV-carried integrins have been sh
Externí odkaz:
https://doaj.org/article/e9adef997f4b4b2d887eeffc4235791e
A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells
Autor:
Bong Hwan Sung, Ariana von Lersner, Jorge Guerrero, Evan S. Krystofiak, David Inman, Roxanne Pelletier, Andries Zijlstra, Suzanne M. Ponik, Alissa M. Weaver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
A prior live-cell exosome reporter showed dim fluorescence and could not be expressed stably, limiting its usefulness. Here the authors stabilise the reporter to allow long-term tracking of exosomes, and incorporate a second fluorophore to visualise
Externí odkaz:
https://doaj.org/article/a92f2f1ca0644dc2b5577af154c973ca
Autor:
Jessica J. Abner, Jeffrey L. Franklin, Margaret A. Clement, Scott A. Hinger, Ryan M. Allen, Xiao Liu, Stefanie Kellner, Junzhou Wu, John Karijolich, Qi Liu, Kasey C. Vickers, Peter Dedon, Alissa M. Weaver, Robert J. Coffey, James G. Patton
Publikováno v:
Heliyon, Vol 7, Iss 12, Pp e08519- (2021)
Extracellular vesicles (EVs) are capable of transferring cargo from donor to recipient cells, but precisely how cargo content is regulated for export is mostly unknown. For miRNA cargo, we previously showed that when compared to isogenic colorectal c
Externí odkaz:
https://doaj.org/article/0841125014be436eb18dc13a0b901a8c
Autor:
Mikin R. Patel, Alissa M. Weaver
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108829- (2021)
Summary: Neuronal synapse formation is critical for brain development and depends on secreted factors from astrocytes. Here, we report that small extracellular vesicles (EVs) secreted from primary astrocytes, but not from neurons or C6 glioma cells,
Externí odkaz:
https://doaj.org/article/ece3fc5cf23b466bbb153ec7cabb343a
Autor:
Andrew J. McKenzie, Daisuke Hoshino, Nan Hyung Hong, Diana J. Cha, Jeffrey L. Franklin, Robert J. Coffey, James G. Patton, Alissa M. Weaver
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 978-987 (2016)
Secretion of RNAs in extracellular vesicles is a newly recognized form of intercellular communication. A potential regulatory protein for microRNA (miRNA) secretion is the critical RNA-induced silencing complex (RISC) component Argonaute 2 (Ago2). He
Externí odkaz:
https://doaj.org/article/ba25df87581a4849b49879ca02acc089
Autor:
Scott A. Hinger, Diana J. Cha, Jeffrey L. Franklin, James N. Higginbotham, Yongchao Dou, Jie Ping, Lihua Shu, Nripesh Prasad, Shawn Levy, Bing Zhang, Qi Liu, Alissa M. Weaver, Robert J. Coffey, James G. Patton
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 715-725.e4 (2018)
Summary: The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distin
Externí odkaz:
https://doaj.org/article/26715246100f4262bdc6f071c3bee262