Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alissa M. Rittenhour"'
Autor:
Seemab S. Shaikh, Bianka Prinz, Juergen H. Nett, Adam Nylen, Fang Li, Alissa M. Rittenhour, Angela Kull, Irina Burnina, Nathan Sharkey, Teresa Mitchell, Natarajan Sethuraman, Thomas I. Potgieter, Terrance A. Stadheim, Dongxing Zha, Piotr Bobrowicz, Heather Lynaugh, Gavin C. Barnard, Youwei Jiang, Sandra Rios
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 37:961-971
The methylotrophic yeast Pichia pastoris has recently been engineered to express therapeutic glycoproteins with uniform human N-glycans at high titers. In contrast to the current art where producing therapeutic proteins in mammalian cell lines yields
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bac6c25035d40fbff8195c96fa5cfaa
https://doi.org/10.1007/s10295-010-0746-1
https://doi.org/10.1007/s10295-010-0746-1
Autor:
Seemab S. Shaikh, Song Lin, Zheng Shen, Alissa M. Rittenhour, Piotr Bobrowicz, Bianka Prinz, Nathan Sharkey, Stephen R. Hamilton, Beata Bobrowicz, Tej Venkatachalam Pavoor, Terrance A. Stadheim, Dongxing Zha, Thomas I. Potgieter
Publikováno v:
Journal of Immunological Methods. 358:66-74
A simple cell labeling method for sorting yeast Pichia pastoris antibody expressing strains is described. A small portion of secreted recombinant antibody retained on the cell surface was labeled with fluorescence detection antibody. The signal inten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb5e6bd7651d3ddc5e094f1f0f5ca8f
https://doi.org/10.1016/j.jim.2010.03.007
https://doi.org/10.1016/j.jim.2010.03.007
Autor:
Youwei Jiang, Nga Rewa Houston-Cummings, Marc d’Anjou, Troy McKelvey, Adam Nylen, Michael Cukan, Alissa M. Rittenhour, Fang Li, Teresa Mitchell, Thomas I. Potgieter, Muralidhar R. Mallem, Heather Lynaugh, Terrance A. Stadheim, Dongxing Zha, James E. Drummond
Publikováno v:
Journal of Biotechnology. 139:318-325
The growing antibody market and the pressure to improve productivity as well as reduce cost of production have fueled the development of alternative expression systems. The therapeutic function of many antibodies is influenced by N-linked glycosylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8c080d7505b30aa74d4f3d687108c6
https://doi.org/10.1016/j.jbiotec.2008.12.015
https://doi.org/10.1016/j.jbiotec.2008.12.015
Autor:
Sujatha Gomathinayagam, Huijuan Li, Juergen H. Nett, Nathan J Sharkey, Min Du, Khanita Karaveg, Stephen R. Hamilton, Terrance A. Stadheim, Alissa M. Rittenhour, Teresa Mitchell, Erik Hoyt, Daniel Hopkins
Publikováno v:
Glycobiology. 21(12)
The methylotrophic yeast, Pichia pastoris, is an important organism used for the production of therapeutic proteins. However, the presence of fungal-like glycans, such as those containing β-mannose (Man) linkages, can elicit an immune response or bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff41c0f48463c1ca0ebb03dcbd91ce58
https://pubmed.ncbi.nlm.nih.gov/21840970
https://pubmed.ncbi.nlm.nih.gov/21840970
Autor:
Teresa I. Mitchell, Piotr Bobrowicz, Huijuan Li, Stephen R. Hamilton, Stefan Wildt, Terrance A. Stadheim, Byung-Kwon Choi, Juergen Hermann Nett, Beata Bobrowicz, Robert C. Davidson, Tillman U. Gerngross, Alissa M. Rittenhour
Publikováno v:
Yeast (Chichester, England). 28(3)
To humanize the glycosylation pathway in the yeast Pichia pastoris, we developed several combinatorial genetic libraries and used them to properly localize active eukaryotic mannosidases and sugar transferases. Here we report the details of the fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632e826afa5af1e010f65151a90a143d
https://pubmed.ncbi.nlm.nih.gov/21360735
https://pubmed.ncbi.nlm.nih.gov/21360735