Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alissa M. Pham"'
Autor:
Alissa M. Pham, Benjamin R. tenOever
Publikováno v:
Viruses, Vol 2, Iss 1, Pp 55-72 (2010)
The ability of a cell to combat an intracellular pathogen requires a mechanism to recognize the threat and elicit a transcriptional response against it. In the context of virus infection, the cell must take measures to inhibit viral replication, mean
Externí odkaz:
https://doaj.org/article/2eaa21787fa843598c00fcf13665229e
Autor:
Alissa M Pham, Felicia Gilfoy Santa Maria, Tanaya Lahiri, Eugene Friedman, Isabelle J Marié, David E Levy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005489 (2016)
Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. Mounting evidence suggests tha
Externí odkaz:
https://doaj.org/article/cb33bc7fc130467bb092f0b5d42cdf1e
Autor:
Leah R. Sabin, Sara Cherry, Jillian S. Shapiro, Bernard Moss, Benjamin R. tenOever, Ismarc Reyes, Simone Backes, Alissa M. Pham
Publikováno v:
Cell Host & Microbe. 12(2):200-210
SUMMARY The life cycle of several viruses involves host or virally encoded small noncoding RNAs, which play important roles in posttranscriptional regulation. Small noncoding RNAs include microRNAs (miRNAs), which modulate the transcriptome, and smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f666ded9fa45419aa1a888e3fc6fb4
Publikováno v:
Molecular Therapy. 20:367-375
The discovery of microRNAs (miRNAs) revealed an unappreciated level of post-transcriptional control used by the cell to maintain optimal protein levels. This process has represented an attractive strategy for therapeutics that is currently limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c0599b9fa8f160cdc6e86416c23f42
https://doi.org/10.1038/mt.2011.244
https://doi.org/10.1038/mt.2011.244
Publikováno v:
RNA. 16:2068-2074
Cellular utilization of RNA interference (RNAi) as a mechanism to combat virus infection is thought to be restricted to plants and invertebrates. In vertebrates, antiviral defenses are largely dependent on interferons (IFNs), with the use of small RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0167c9b342abbf2335ab04221c60a9
https://doi.org/10.1261/rna.2303610
https://doi.org/10.1261/rna.2303610
Autor:
Uri Hershberg, Stuart C. Sealfon, James G. Wetmur, Jeremy Seto, Jamie L. Duke, Elena Zaslavsky, Susanna Marquez, Alissa M. Pham, Steven H. Kleinstein, Benjamin R. tenOever
Publikováno v:
The Journal of Immunology. 184:2908-2917
The dendritic cell (DC) is a master regulator of immune responses. Pathogenic viruses subvert normal immune function in DCs through the expression of immune antagonists. Understanding how these antagonists interact with the host immune system require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce027a89d5593fc40de4b5bb9bd13b7
https://doi.org/10.4049/jimmunol.0903453
https://doi.org/10.4049/jimmunol.0903453
Publikováno v:
Virology Journal
Background The outcome of a viral infection is regulated by complex interactions of viral and host factors. SARS coronavirus (SARS-CoV) engages and regulates several innate immune response pathways during infection. We have previously shown that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b625491956fa7c49f33ca9dbf4483d
https://doi.org/10.1186/s12985-014-0209-9
https://doi.org/10.1186/s12985-014-0209-9
Autor:
Carles Martínez-Romero, Alissa M. Pham, Adolfo García-Sastre, Benjamin R. tenOever, Giuseppe Pisanelli, Juliet Morrison, Juan Ayllon, Maudry Laurent-Rolle, Ricardo Rajsbaum, Lisa Miorin, Jesica M. Levingston Macleod
Publikováno v:
Cell host & microbe, vol 16, iss 3
SummaryTo successfully establish infection, flaviviruses have to overcome the antiviral state induced by type I interferon (IFN-I). The nonstructural NS5 proteins of several flaviviruses antagonize IFN-I signaling. Here we show that yellow fever viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee29219480553c7324dc6c9358694e3a
https://escholarship.org/uc/item/8h37m402
https://escholarship.org/uc/item/8h37m402
Autor:
Eugene Friedman, Tanaya Lahiri, Felicia Gilfoy Santa Maria, David E. Levy, Isabelle Marie, Alissa M. Pham
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005489 (2016)
PLoS Pathogens
PLoS Pathogens
Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. Mounting evidence suggests tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571a3d402fc5cc736db3c75b7c898f00
https://doi.org/10.1371/journal.ppat.1005489
https://doi.org/10.1371/journal.ppat.1005489
Publikováno v:
RNA (New York, N.Y.). 18(7)
microRNAs (miRNAs) represent a class of noncoding RNAs that fine-tune gene expression through post-transcriptional silencing. While miRNA biogenesis occurs in a stepwise fashion, initiated by the nuclear microprocessor, rare noncanonical miRNAs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5b6c6d30821373eecebffca88c4013
https://pubmed.ncbi.nlm.nih.gov/22635403
https://pubmed.ncbi.nlm.nih.gov/22635403