Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alissa L. W. Kleinhenz"'
Autor:
Robert J. Lefkowitz, Alissa L. W. Kleinhenz, Meredith A. Skiba, Andrew C. Kruse, Carl-Mikael Suomivuori, Conor McMahon, Dean P. Staus, Ron O. Dror, Naomi R. Latorraca, Laura M. Wingler
Publikováno v:
Science
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6a468f15f31a04e563eca4ab612dd6
https://doi.org/10.1126/science.aay9813
https://doi.org/10.1126/science.aay9813
Autor:
Robert J. Lefkowitz, William D. Capel, Michael J. Robertson, Georgios Skiniotis, Alissa L. W. Kleinhenz, Dean P. Staus, Naomi R. Latorraca, Laura M. Wingler, Hongli Hu
Publikováno v:
Nature
After activation by an agonist, G-protein-coupled receptors (GPCRs) recruit β-arrestin, which desensitizes heterotrimeric G-protein signalling and promotes receptor endocytosis1. Additionally, β-arrestin directly regulates many cell signalling path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efd599fe56055577c922d7be1c08c5
https://doi.org/10.1038/s41586-020-1954-0
https://doi.org/10.1038/s41586-020-1954-0
Autor:
Alissa L. W. Kleinhenz, Matthew C. King, Naomi R. Latorraca, Carl-Mikael Suomivuori, Robert J. Lefkowitz, Stephan Eismann, Ron O. Dror, Meredith A. Skiba, Andrew C. Kruse, Laura M. Wingler, Dean P. Staus
Publikováno v:
Science
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c630ae3efc9ed2a68c9d366e2c62f34
https://europepmc.org/articles/PMC7259329/
https://europepmc.org/articles/PMC7259329/
Autor:
Stephan Eismann, Alissa L. W. Kleinhenz, Andrew C. Kruse, Ron O. Dror, Carl-Mikael Suomivuori, Meredith A. Skiba, Robert J. Lefkowitz, Laura M. Wingler, Dean P. Staus, Matthew C. King, Naomi R. Latorraca
Publikováno v:
Biophysical Journal. 118:162a
Biased signaling, in which different ligands that bind to the same G protein-coupled receptor preferentially trigger distinct signaling pathways, holds great promise for the design of safer and more effective drugs. Its structural mechanism remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26fb96eebc6dfbd243374eb964d06f80
https://doi.org/10.1016/j.bpj.2019.11.1000
https://doi.org/10.1016/j.bpj.2019.11.1000
Autor:
Staus, Dean P., Hu, Hongli, Robertson, Michael J., Kleinhenz, Alissa L. W., Wingler, Laura M., Capel, William D., Latorraca, Naomi R., Lefkowitz, Robert J., Skiniotis, Georgios
Publikováno v:
Nature; 3/12/2020, Vol. 579 Issue 7798, p297-302, 6p, 3 Diagrams, 2 Graphs