Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Alissa J, Cooper"'
Autor:
Alissa J. Cooper, MD, Alona Muzikansky, MA, Jochen Lennerz, MD, PhD, Farhaana Narinesingh, M.B.B.S., Mari Mino-Kenudson, MD, Yin P. Hung, MD, PhD, Zofia Piotrowska, MD, MHS, Ibiayi Dagogo-Jack, MD, Lecia V. Sequist, MD, MPH, Justin F. Gainor, MD, Jessica J. Lin, MD, Rebecca S. Heist, MD, MPH
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 9, Pp 100390- (2022)
Introduction: Co-occurring mutations in KRAS-mutant NSCLC are associated with discrete biological properties and modulate therapeutic susceptibilities. As G12D-specific inhibitors are expected to enter the clinic, we sought to investigate the charact
Externí odkaz:
https://doaj.org/article/b74d2bef942c4556b6ea5685e2ff735a
Autor:
Alissa J. Cooper, Rebecca S. Heist
Publikováno v:
Hematology/Oncology Clinics of North America. 37:623-658
Autor:
Marcelo V. Negrao, Haniel A. Araujo, Giuseppe Lamberti, Alissa J. Cooper, Neal S. Akhave, Teng Zhou, Lukas Delasos, J Kevin. Hicks, Mihaela Aldea, Gabriele Minuti, Jacobi Hines, Jacqueline V. Aredo, Michael J. Dennis, Turja Chakrabarti, Susan C. Scott, Paolo Bironzo, Matthias Scheffler, Petros Christopoulos, Albrecht Stenzinger, Jonathan W. Riess, So Yeon Kim, Sarah B. Goldberg, Mingjia Li, Qi Wang, Yun Qing, Ying Ni, Minh Truong Do, Richard Lee, Biagio Ricciuti, Joao Victor. Alessi, Jing Wang, Blerina Resuli, Lorenza Landi, Shu-Chi Tseng, Mizuki Nishino, Subba R. Digumarthy, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Ara A Vaporciyan, George R. Blumenschein, Jianjun Zhang, Dwight H. Owen, Collin M. Blakely, Giannis Mountzios, Catherine A. Shu, Christine M. Bestvina, Marina Chiara. Garassino, Kristen A. Marrone, Jhanelle E. Gray, Sandip Pravin. Patel, Amy L. Cummings, Heather A. Wakelee, Juergen Wolf, Giorgio Vittorio. Scagliotti, Federico Cappuzzo, Fabrice Barlesi, Pradnya D. Patil, Leylah Drusbosky, Don L. Gibbons, Funda Meric-Bernstam, J. Jack Lee, John V. Heymach, David S. Hong, Rebecca S. Heist, Mark M. Awad, Ferdinandos Skoulidis
Publikováno v:
Cancer Discovery.
Molecular modifiers of KRAS G12C inhibitor (KRAS G12Ci) efficacy in advanced KRAS G12C-mutant NSCLC are poorly defined. In a large unbiased clinico-genomic analysis of 424 NSCLC patients, we identified and validated co-alterations in KEAP1, SMARCA4 a
Publikováno v:
Nat Rev Clin Oncol
The discoveries of EGFR mutations and ALK rearrangements as actionable oncogenic drivers in non-small-cell lung cancer (NSCLC) has propelled a biomarker-directed treatment paradigm for patients with advanced-stage disease. Numerous EGFR and ALK tyros
Autor:
Geoffrey R. Oxnard, Pasi A Jänne, Lynette M. Sholl, Nikhil Wagle, Michael S. Rabin, Daniel B. Costa, Tom Nguyen, Deepa Rangachari, Jiaqi Li, Emily S. Chambers, Suzanne E. Dahlberg, Sasha Kravets, Sarah E. Clifford, Dewey Kim, Yoshihisa Kobayashi, Alissa J. Cooper
Supplementary Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a28c0a9311ef71cba32659450ad1737
https://doi.org/10.1158/1078-0432.22477760.v1
https://doi.org/10.1158/1078-0432.22477760.v1
Autor:
Geoffrey R. Oxnard, Pasi A Jänne, Lynette M. Sholl, Nikhil Wagle, Michael S. Rabin, Daniel B. Costa, Tom Nguyen, Deepa Rangachari, Jiaqi Li, Emily S. Chambers, Suzanne E. Dahlberg, Sasha Kravets, Sarah E. Clifford, Dewey Kim, Yoshihisa Kobayashi, Alissa J. Cooper
Thirteen patients were enrolled and underwent at least one cycle of therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb66c5a7ebcfef23c2aa089f0e94a74
https://doi.org/10.1158/1078-0432.22477766
https://doi.org/10.1158/1078-0432.22477766
Autor:
Geoffrey R. Oxnard, Pasi A Jänne, Lynette M. Sholl, Nikhil Wagle, Michael S. Rabin, Daniel B. Costa, Tom Nguyen, Deepa Rangachari, Jiaqi Li, Emily S. Chambers, Suzanne E. Dahlberg, Sasha Kravets, Sarah E. Clifford, Dewey Kim, Yoshihisa Kobayashi, Alissa J. Cooper
Screening with drugs targeting sunitinib related receptor tyrosine kinases (RTK) or MAPK pathway were performed in PC9TMEM87A-RASGRF1 clone 1. Relative viability compared with control (treated with DMSO) was shown. A modest inhibitory effect was seen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a632bc56561f6194a53b41684539db4
https://doi.org/10.1158/1078-0432.22477763.v1
https://doi.org/10.1158/1078-0432.22477763.v1
Autor:
Geoffrey R. Oxnard, Pasi A Jänne, Lynette M. Sholl, Nikhil Wagle, Michael S. Rabin, Daniel B. Costa, Tom Nguyen, Deepa Rangachari, Jiaqi Li, Emily S. Chambers, Suzanne E. Dahlberg, Sasha Kravets, Sarah E. Clifford, Dewey Kim, Yoshihisa Kobayashi, Alissa J. Cooper
Purpose:We pursued genomic analysis of an exceptional responder with non–small cell lung cancer (NSCLC) through a multi-platform effort to discover novel oncogenic targets.Experimental Design:In this open-label, single-arm phase II study (NCT018292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9912984979633083346795b1d40dac90
https://doi.org/10.1158/1078-0432.c.6529754.v1
https://doi.org/10.1158/1078-0432.c.6529754.v1
Autor:
Geoffrey R. Oxnard, Pasi A Jänne, Lynette M. Sholl, Nikhil Wagle, Michael S. Rabin, Daniel B. Costa, Tom Nguyen, Deepa Rangachari, Jiaqi Li, Emily S. Chambers, Suzanne E. Dahlberg, Sasha Kravets, Sarah E. Clifford, Dewey Kim, Yoshihisa Kobayashi, Alissa J. Cooper
Post-baseline toxicity incidence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccacd050c50dae9d90d6d4ae615cfce
https://doi.org/10.1158/1078-0432.22477751.v1
https://doi.org/10.1158/1078-0432.22477751.v1
Autor:
Alissa J. Cooper, Justin F. Gainor
Publikováno v:
Journal of Clinical Oncology. 40:693-697