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pro vyhledávání: '"Alissa Basehoar"'
Autor:
Alissa Basehoar, Donald M. Simons, Andrew J. Caton, Soyoung Oh, Elizabeth Kropf, Malinda Aitken, Victoria Garcia
Publikováno v:
The Journal of Immunology. 190:3134-3141
We have examined mechanisms underlying the formation of pathologic Th17 cells using a transgenic mouse model in which autoreactive CD4+ T cells recognize influenza virus hemagglutinin (HA) as a ubiquitously expressed self-Ag and induce inflammatory a
Autor:
Elizabeth Kropf, Soyoung Oh, Malinda Aitken, Victoria Garcia, Alissa Basehoar, Andrew J. Caton, Donald M. Simons
Publikováno v:
The Journal of Immunology. 188:4171-4180
CD4+CD25+Foxp3+ regulatory T cells (Tregs) are required to restrain the immune system from mounting an autoaggressive systemic inflammatory response, but why their activity can prevent (or allow) organ-specific autoimmunity remains poorly understood.
Autor:
Laura Panarey, Alissa Basehoar, Andrew J. Caton, Soyoung Oh, Malinda Aitken, Cristina Cozzo Picca
Publikováno v:
European Journal of Immunology. 39:3301-3306
Autoreactive CD4+ T cells can undergo deletion and/or become CD25+Foxp3+ Treg as they develop intrathymically, but how these alternative developmental fates are specified based on interactions with self-peptide(s) is not understood. We show here that