Výsledky vyhledávání - "Alissa A Hare"

Akademický článek

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.

Autor: Amanda E Hargrove, Thomas F Martinez, Alissa A Hare, Alexis A Kurmis, John W Phillips, Sudha Sud, Kenneth J Pienta, Peter B Dervan

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143161 (2015)

Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen respons

Externí odkaz: https://doaj.org/article/0e0f266dcfb74ee5b9dab35d6f5d1fe0

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Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides

Autor: Amanda Silberstein, Lina He, Bogdan Olenyuk, Joseph W. Stiles, Tiezheng Jia, Thomas F. Martinez, Alissa A. Hare, Yang Li, Bangyan L. Stiles, Peter B. Dervan, John Gallagher, Chien-Yu Chen

Publikováno v: Med Chem Res
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, vol 29, iss 4

The orphan nuclear receptors estrogen-related receptors (ERRs) bind to the estrogen-related receptor response element (ERRE) to regulate transcriptional programs in cellular metabolism and cancer cell growth. In this study, we evaluated the potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4ef2e105e0b11764d04977cd0da9e9
https://resolver.caltech.edu/CaltechAUTHORS:20200226-143501183

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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

Autor: Adam D. Wier, Jun Xu, Michael A. Cianfrocco, Alissa A. Hare, Wei Wang, Peter B. Dervan, Jenny Chong, Indrajit Lahiri, Frank DiMaio, Andres E. Leschziner, Dong Wang

Publikováno v: Nature. 551:653-657

Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-pathway of nucleotide excision repair that preferentially removes DNA lesions from the template strand that block translocation of RNA polymerase II (Pol II). Cockay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa3da216cab6da36d0b4cb1a33ae4f8
https://doi.org/10.1038/nature24658

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Design, Synthesis, and Protein Crystallography of Biaryltriazoles as Potent Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor

Autor: Michael J. Robertson, Nadia E. Danford, José A. Cisneros, Pawel Dziedzic, Richard H. G. Baxter, William L. Jorgensen, Alissa A. Hare

Publikováno v: Journal of the American Chemical Society. 137:2996-3003

Optimization is reported for biaryltriazoles as inhibitors of the tautomerase activity of human macrophage migration inhibitory factor (MIF), a proinflammatory cytokine associated with numerous inflammatory diseases and cancer. A combined approach wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c6da02473879e3ebb0f01f5731feb2
https://doi.org/10.1021/ja512112j

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RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

Autor: Alissa A. Hare, Timothy R. Welch, Jeffrey N. Strathern, Liang Xu, Dong Wang, Ji Hyun Shin, Peter B. Dervan, Wei Wang, Fei Yang, Benjamin C. Li, Jenny Chong, Deanna Gotte

RNA polymerase II (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, DNA lesions, and nucleosomes. Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA with programmable sequence specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940e020de05acfdca9748b12e7a37fe9
https://resolver.caltech.edu/CaltechAUTHORS:20161020-165432331

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Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)

Autor: William L. Jorgensen, Xin Du, Alissa A. Hare, Sunilkumar Gandavadi, Lin Leng, Zoe Cournia, Richard Bucala

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:5811-5814

The cytokine MIF is involved in inflammation and cell proliferation via pathways initiated by its binding to the transmembrane receptor CD74. MIF also exhibits keto–enol tautomerase activity, believed to be vestigial in mammals. Starting from a 1 �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f39505f4bd87dc03681a8c461312c7d
https://doi.org/10.1016/j.bmcl.2010.07.129

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Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide

Autor: Peter B. Dervan, Thomas F. Martinez, John W. Phillips, Sudha Sud, Alexis A. Kurmis, Amanda E. Hargrove, Alissa A. Hare, Kenneth J. Pienta

Publikováno v: PloS one, vol 10, iss 11
PLoS ONE, Vol 10, Iss 11, p e0143161 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75a3b2d2d326a7dd4ae4b7679b3d331
https://escholarship.org/uc/item/9jr0m0h9

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Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction

Autor: Xiaoyan Yan, Chao Tong, Alissa A. Hare, Eddie D Yeung, Lin Leng, Huabao Xiong, Yibang Chen, Richard Bucala, Changxing Ma, William L. Jorgensen, Sunilkumar Gandavadi, Jingying Wang, Xin Du, Ji Li, Lawrence H. Young

Publikováno v: Circulation. 128(3)

Background— Macrophage migration inhibitory factor (MIF) exerts a protective effect on ischemic myocardium by activating AMP-activated protein kinase (AMPK). Small molecules that increase the affinity of MIF for its receptor have been recently desi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714aab7944aa197ba7395cfdccf6645c
https://pubmed.ncbi.nlm.nih.gov/23753877

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Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor

Autor: Julian Tirado-Rives, Alissa A. Hare, Alvaro Baeza Garcia, Markus K. Dahlgren, Lin Leng, Richard Bucala, William L. Jorgensen

Publikováno v: Journal of medicinal chemistry. 55(22)

The Plasmodium falciparum ortholog of the human cytokine, macrophage migratory inhibitory factor (PfMIF), is produced by the parasite during malaria infection and modulates the host’s immune response. As for other MIF orthologs, PfMIF has tautomera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc19ca61c4313485baf6d973d19787c
https://pubmed.ncbi.nlm.nih.gov/23067344

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Benzisothiazolones as modulators of macrophage migration inhibitory factor

Autor: Alissa A. Hare, Lin Leng, Richard Bucala, Alexander Trofimov, William L. Jorgensen, Xin Du

Substituted N-phenylbenzisothiazolones have been investigated as inhibitors of the tautomerase activity of the proinflammatory cytokine MIF (macrophage migration inhibitory factor). Numerous compounds were found to possess antagonist activity in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40905f0e38b9357b040b7f0e9bbead09
https://europepmc.org/articles/PMC3139435/

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