Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alissa, Myrick"'
Autor:
Preshendren Govender, Rudolf Müller, Kawaljit Singh, Virsinha Reddy, Charles J. Eyermann, Stephen Fienberg, Sandeep R. Ghorpade, Lizbé Koekemoer, Alissa Myrick, Dirk Schnappinger, Curtis Engelhart, Jaclynn Meshanni, Jo Ann W. Byl, Neil Osheroff, Vinayak Singh, Kelly Chibale, Gregory S. Basarab
Publikováno v:
J Med Chem
This is the accepted manuscript version of the work published in its final form as Govender, P., Müller, R., Singh, K., Reddy, V., Eyermann, C. J., Fienberg, S., Ghorpade, S. R., Koekemoer, L., Myrick, A., Schnappinger, D., Engelhart, C., Meshanni,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998b904662397f27672f135b544426e0
https://doi.org/10.1021/acs.jmedchem.2c00266
https://doi.org/10.1021/acs.jmedchem.2c00266
Autor:
Stephen Fienberg, Gregory S. Basarab, Anne J. Lenaerts, Virsinha Reddy, Sandeep R. Ghorpade, Mathew Njoroge, Grant A. Boyle, Charles J. Eyermann, Clifton E. Barry, Timothy G. Myers, Efrem Abay, Nina Lawrence, Alissa Myrick, Helena I. Boshoff, Vinayak Singh, Lutete Peguy Khonde, Lisa M. Massoudi, Paul D. van Helden, Frederick A. Sirgel, Gregory T. Robertson, Rudolf Müller, Kelly Chibale, Aloysius T. Nchinda, Qin Su
Publikováno v:
Journal of Medicinal Chemistry. 64:12790-12807
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd5171702dfa2d1b82d5b9180cddebb
https://doi.org/10.1021/acs.jmedchem.1c00837
https://doi.org/10.1021/acs.jmedchem.1c00837
Autor:
Anthony J. Smith, Dale Taylor, Anne J. Lenaerts, Thomas R. Ioerger, Nina Lawrence, Kelly Chibale, Rudolf Mueller, Vinayak Singh, Claire Le Manach, Aloysius T. Nchinda, Alissa Myrick, Mathew Njoroge, Paul M. Njaria, Elizabeth J. Brooks, Atica Moosa, Jessica N. Akester, Gregory T. Robertson
Publikováno v:
ACS Infectious Diseases
Phenotypic whole-cell screening against Mycobacterium tuberculosis (Mtb) in glycerol-alanine-salts supplemented with Tween 80 and iron (GASTE-Fe) media led to the identification of a 2-aminoquinazolinone hit compound, sulfone 1 which was optimized fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5442c3902e05983890e5f02f889b02
http://europepmc.org/articles/PMC7359024
http://europepmc.org/articles/PMC7359024
Autor:
Lutete Peguy, Khonde, Rudolf, Müller, Grant A, Boyle, Virsinha, Reddy, Aloysius T, Nchinda, Charles J, Eyermann, Stephen, Fienberg, Vinayak, Singh, Alissa, Myrick, Efrem, Abay, Mathew, Njoroge, Nina, Lawrence, Qin, Su, Timothy G, Myers, Helena I M, Boshoff, Clifton E, Barry, Frederick A, Sirgel, Paul D, van Helden, Lisa M, Massoudi, Gregory T, Robertson, Anne J, Lenaerts, Gregory S, Basarab, Sandeep R, Ghorpade, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(17)
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9d052174dfa5e731d4d84ef57053ad6
https://pubmed.ncbi.nlm.nih.gov/34414766
https://pubmed.ncbi.nlm.nih.gov/34414766
Autor:
Kirsteen I. Buchanan, Clifton E. Barry, Simon Green, Gregory S. Basarab, Qin Su, Charles J. Eyermann, Curtis A. Engelhart, Anuradha Kumar, Paul D. van Helden, Frederick A. Sirgel, Paul G. Wyatt, Nina Lawrence, Sandeep R. Ghorpade, Dirk Schnappinger, Dale Taylor, Sandile B. Simelane, Helena I. Boshoff, Christel Brunschwig, Vinayak Singh, Kelly Chibale, Peter C. Ray, Tracy Bayliss, Candice Soares de Melo, Alissa Myrick, Tanya Parish, Timothy G. Myers
Publikováno v:
Journal of Medicinal Chemistry
Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of Mtb sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5eafa1e33ac7c64b2164da5d55d9f9
https://pubmed.ncbi.nlm.nih.gov/33395287
https://pubmed.ncbi.nlm.nih.gov/33395287
Autor:
Dana Boyd, Holly K. Arnold, Ludmila Bronstain, Brian M. Meehan, Shoko Minami, Cristina Landeta, Eric J. Rubin, Na Ke, Alissa Myrick, Feras Hatahet, Rachel J. Dutton, Jessica L. Blazyk, Bruce Furie, Barbara C. Furie, Jon Beckwith, Markus Eser
Publikováno v:
Nature chemical biology
In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond. These proteins include numerous bacterial virulence factors, and thus bacterial enzymes that promote disulfide bond formation represent targets fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a6751ee8fe06ead584779d5fc0b11b
http://europepmc.org/articles/PMC4366281
http://europepmc.org/articles/PMC4366281
Autor:
Likai Song, Huan-Xiang Zhou, Frantz Jean-Francois, Alissa Myrick, Eric J. Rubin, Lu Yu, Piotr G. Fajer, Jian Dai, Timothy A. Cross
Publikováno v:
Journal of Molecular Biology. 426:436-446
MgtR, a highly hydrophobic peptide expressed in Salmonella enterica serovar Typhimurium,inhibits growth in macrophages through binding to the membrane protein MgtC that has been identified as essential for replication in macrophages. While the Mycoba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab777998d29c36c9ece5a247aa0deb
https://doi.org/10.1016/j.jmb.2013.10.014
https://doi.org/10.1016/j.jmb.2013.10.014
Autor:
Alissa Myrick, Carolyn K. Dong, Karine G. Le Roch, Dyann F. Wirth, Jennifer S. Sims, Elizabeth A. Winzeler, Todd Gierahn, Kevin T. Militello, Anusha Gunasekera
Publikováno v:
Molecular and Biochemical Parasitology. 153:19-30
Control of gene expression is poorly understood in the Plasmodium system, where relatively few homologues to known eukaryotic transcription factors have been uncovered. Recent evidence suggests that the parasite may utilize a combinatorial mode of ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae5b7fcf93d3859a412e3a19410e3bf
https://doi.org/10.1016/j.molbiopara.2007.01.011
https://doi.org/10.1016/j.molbiopara.2007.01.011
Autor:
Karen P. Day, Alissa Myrick, Dyann F. Wirth, Sarah K. Volkman, Lara Bethke, Stanley Sawyer, Alyssa E. Barry, Daniel L. Hartl, Trevor Bedford, Elena R. Lozovsky
Publikováno v:
Gene. 387:1-6
The density and distribution of single-nucleotide polymorphisms (SNPs) across the genome has important implications for linkage disequilibrium mapping and association studies, and the level of simple-sequence microsatellite polymorphisms has importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986102f3f534fbedf4b4b2a76a4333c5
https://doi.org/10.1016/j.gene.2006.07.026
https://doi.org/10.1016/j.gene.2006.07.026
Autor:
Philip J. Rosenthal, Elaine J. Carlson, Jonathan M. Woo, Grant Dorsey, Bryan Greenhouse, Christian Dokomajilar, Alissa Myrick
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 75:836-842
Genotyping methods for Plasmodium falciparum drug efficacy trials have not been standardized and may fail to accurately distinguish recrudescence from new infection, especially in high transmission areas where polyclonal infections are common. We dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6641179f7f9d345a879ad0d08e24192
https://doi.org/10.4269/ajtmh.2006.75.836
https://doi.org/10.4269/ajtmh.2006.75.836