Výsledky vyhledávání - "Alison W. Tisdale"

Data from A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling

Autor: K. Dane Wittrup, Michael T. Hemann, Christian J. Braun, Ryan L. Kelly, Alison W. Tisdale, Monique J. Kauke

Mutated in approximately 30% of human cancers, Ras GTPases are the most common drivers of oncogenesis and render tumors unresponsive to many standard therapies. Despite decades of research, no drugs directly targeting Ras are currently available. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43eee4f01b70dca9119d86936d6043a5
https://doi.org/10.1158/1535-7163.c.6537837.v1

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Supplementary figures from A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling

Autor: K. Dane Wittrup, Michael T. Hemann, Christian J. Braun, Ryan L. Kelly, Alison W. Tisdale, Monique J. Kauke

Supplementary Figure S1. Cell lines constitutively express R11.1.6 or control proteins YW1 and EGFP. a, Flow cytometry histograms of human cancer cell lines A431, HT-29, LS180, and HPAF-II, transduced to constitutively express EGFP, R11.1.6 (and an E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3821b86b5e150248cb82275e07830ab9
https://doi.org/10.1158/1535-7163.22504734.v1

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PR_b functionalized stealth liposomes for targeted delivery to metastatic colon cancer

Autor: Brent S. Sorenson, R. Scott McIvor, Rachel M. Levine, Lalitha R. Belur, Alison W. Tisdale, Efrosini Kokkoli, Timothy R. Pearce, Maroof M. Adil

Publikováno v: Biomaterials science. 1(4)

A gene delivery system was designed to carry a payload to integrin overexpressing cells. Branched-polyethyleneimine (bPEI) condensed plasmid DNA was encapsulated into targeted stealth liposomes, thereby combining the condensing and transfection prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1b7e53362b2e40372014e6eed0dce0
https://pubmed.ncbi.nlm.nih.gov/32481904

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Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library

Autor: Michael W, Traxlmayr, Jonathan D, Kiefer, Raja R, Srinivas, Elisabeth, Lobner, Alison W, Tisdale, Naveen K, Mehta, Nicole J, Yang, Bruce, Tidor, K Dane, Wittrup

Publikováno v: The Journal of Biological Chemistry

The Sso7d protein from the hyperthermophilic archaeon Sulfolobus solfataricus is an attractive binding scaffold because of its small size (7 kDa), high thermal stability (Tm of 98 °C), and absence of cysteines and glycosylation sites. However, as a

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https://pubmed.ncbi.nlm.nih.gov/27582495

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Evaluating Oversight of Human Drugs and Medical Devices: A Case Study of the FDA and Implications for Nanobiotechnology

Autor: Alison W. Tisdale, Ralph F. Hall, Efrosini Kokkoli, Jordan Paradise

Publikováno v: Journal of Law, Medicine & Ethics. 37:598-624

This article evaluates the oversight of drugs and medical devices by the U.S. Food and Drug Administration (FDA) using an integration of public policy, law, and bioethics approaches and employing multiple assessment criteria, including economic, soci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6b7cde7aa8204bfc8f758d5c6a8ce9
https://doi.org/10.1111/j.1748-720x.2009.00434.x

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Developing U.S. oversight strategies for nanobiotechnology: learning from past oversight experiences

Autor: Efrosini Kokkoli, Alison W. Tisdale, Jennifer Kuzma, Aliya Kuzhabekova, Jordan Paradise, Susan M. Wolf, Gurumurthy Ramachandran

Publikováno v: The Journal of law, medicineethics : a journal of the American Society of Law, MedicineEthics. 37(4)

The emergence of nanotechnology, and specifically nanobiotechnology, raises major oversight challenges. In the United States, government, industry, and researchers are debating what oversight approaches are most appropriate. Among the federal agencie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a41419756363633ed8020438df1ce6d
https://pubmed.ncbi.nlm.nih.gov/20122110

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Targeting Colon Cancer Cells Using PEGylated Liposomes Modified With a Fibronectin-Mimetic Peptide

Autor: Alison W. Tisdale, Efrosini Kokkoli, Ashish Garg

Publikováno v: Journal of Medical Devices. 3

The ability to target cancer cells using an appropriate drug delivery system can significantly reduce the associated side effects from cancer therapies and can help in improving overall quality of life post cancer survival. Integrin α5β1 is express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3aed1878a3bf983d99a4284916e8ca86
https://doi.org/10.1115/1.3135154

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Targeting colon cancer cells using PEGylated liposomes modified with a fibronectin-mimetic peptide

Autor: Alison W. Tisdale, Ashish Garg, Eman Haidari, Efrosini Kokkoli

Integrin alpha(5)beta(1) is expressed on several types of cancer cells, including colon cancer, and plays an important role in tumor growth and metastasis. The ability to target the integrin alpha(5)beta(1) using an appropriate drug delivery nano-vec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5bf021b848c603111cd826ee3eab8e
https://europepmc.org/articles/PMC2660894/

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Exploring emerging nanobiotechnology drugs and medical devices

Autor: Jordan, Paradise, Gail Mattey, Diliberto, Alison W, Tisdale, Efrosini, Kokkoli

Publikováno v: Food and drug law journal. 63(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb0901b7adefd60ffe28553c40c6468c
https://pubmed.ncbi.nlm.nih.gov/18561467

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