Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alison V. Todd"'
Autor:
Sepehr N Tabrizi, Lit Y Tan, Samantha Walker, Jimmy Twin, Marin Poljak, Catriona S Bradshaw, Christopher K Fairley, Melanie Bissessor, Elisa Mokany, Alison V Todd, Suzanne M Garland
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156740 (2016)
Mycoplasma genitalium is a cause of non-gonoccocal urethritis (NGU) in men and cervicitis and pelvic inflammatory disease in women. Recent international data also indicated that the first line treatment, 1 gram stat azithromycin therapy, for M. genit
Externí odkaz:
https://doaj.org/article/b466b8e531a143cc92bb0844dda3fff9
Publikováno v:
Molecules, Vol 25, Iss 1755, p 1755 (2020)
Molecules
Volume 25
Issue 7
Molecules
Volume 25
Issue 7
The development of Subzymes demonstrates how the catalytic activity of DNAzymes can be controlled for detecting nucleic acids
however, Subzymes alone lack the sensitivity required to detect low target concentrations. To improve sensitivity, we d
however, Subzymes alone lack the sensitivity required to detect low target concentrations. To improve sensitivity, we d
Publikováno v:
Poster Presentations.
Background Major challenges in the management of infectious diseases include treatment failure due to antimicrobial resistance (AMR) and the lack of a reliable test of cure (TOC). Whilst culture is a trusted method it is slow, and with the widespread
EzyAmp signal amplification cascade enables isothermal detection of nucleic acid and protein targets
Autor:
Alison V. Todd, Evelyn Meiria Linardy, Nicole E. Lima, Elisa Mokany, Tina Lonergan, Simon Erskine
Publikováno v:
Biosensors and Bioelectronics. 75:59-66
Advancements in molecular biology have improved the ability to characterize disease-related nucleic acids and proteins. Recently, there has been an increasing desire for tests that can be performed outside of centralised laboratories. This study desc
Publikováno v:
Sensors and Actuators B: Chemical. 297:126704
Rapid, sensitive and affordable nucleic acid sensors that can operate in a point of care (POC) setting are highly desired; however, their availability and implementation remain limited. We report the development of a strategy for building sensors whi
Publikováno v:
Biosensors and Bioelectronics. 70:330-337
We have created molecular switches that consist of nucleic-acid cleaving DNAzymes which are temporarily inactivated by hybridization with blocking oligonucleotides. The unique design of the switches offers significant advantages over existing methods
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170087 (2017)
PLoS ONE
PLoS ONE
Background Whilst qPCR provides an extremely powerful tool for genetic analysis, some applications such as multiplexing variant alleles (eg SNPs, point mutations or deletions), remain challenging using current primer/probe systems. The novel design f
Publikováno v:
Analytical Chemistry. 86:9106-9113
Diagnostic tests performed in the field or at the site of patient care would benefit from using a combination of inexpensive, stable chemical reagents and simple instrumentation. Here, we have developed a universal "DNA-only Cascade" (DoC) to quantit
Autor:
Marin Poljak, Samantha Walker, Elisa Mokany, Suzanne M. Garland, Christopher K Fairley, Lit Yeen Tan, Sepehr N. Tabrizi, Catriona S. Bradshaw, Melanie Bissessor, Alison V. Todd, Jimmy Twin
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156740 (2016)
PLoS ONE
PLoS ONE
Mycoplasma genitalium is a cause of non-gonoccocal urethritis (NGU) in men and cervicitis and pelvic inflammatory disease in women. Recent international data also indicated that the first line treatment, 1 gram stat azithromycin therapy, for M. genit
Publikováno v:
Journal of the American Chemical Society
To increase the versatility and utility of nucleic acid enzymes, we developed multicomponent complexes, known as MNAzymes, which produce amplified "output" signals in response to specific "input" signals. Multiple oligonucleotide partzymes assemble i