Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Alison T. Ung"'
Autor:
Alison T. Ung, Matthew Payne
Publikováno v:
AppliedChem, Vol 3, Iss 4, Pp 509-525 (2023)
Through the Lilly Open Innovation Drug Discovery program (OIDD), we discovered five cationic bis(aryltriazol-4-yl)methyl)-6,7-dimethoxytetrahydroisoquinolinium derivatives that effectively inhibit human nicotinamide N-methyltransferase. Compounds 4a,
Externí odkaz:
https://doaj.org/article/7f4cc2e2d64b4a38bf1c18efbe8c7060
Publikováno v:
AppliedChem, Vol 3, Iss 2, Pp 256-278 (2023)
Novel SF5-bearing maleimide and acrylamide derivatives were synthesised as potential [18F]radio-prosthetic groups for radiolabelling peptides and proteins. The efficacy of selected prosthetic groups was first assessed through bioconjugation with prot
Externí odkaz:
https://doaj.org/article/38bb9aeb8a224f96bd63bdb076b44e48
Publikováno v:
Molecules, Vol 28, Iss 18, p 6677 (2023)
Acacia saligna’s secondary metabolites show promise in treating type 2 diabetes mellitus and its related conditions. We previously discovered that methanolic extracts, isolated flavonoids, and cyclitols effectively preserve mitochondria in 3T3-L1 a
Externí odkaz:
https://doaj.org/article/a7df83f1a4634e2c96ca3fafb415c481
Autor:
Panthakarn Rangsinth, Chanin Sillapachaiyaporn, Sunita Nilkhet, Tewin Tencomnao, Alison T. Ung, Siriporn Chuchawankul
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 11, Iss 2, Pp 158-172 (2021)
Background and aim: Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now become the world pandemic. There is a race to develop suitable drugs and vaccines for the disease. The anti-HIV pro
Externí odkaz:
https://doaj.org/article/c9618b9a9e94451aba5a82193fecae59
Autor:
Alison T. Ung, Anjar P. Asmara
Publikováno v:
Molecules, Vol 28, Iss 11, p 4396 (2023)
Acacia saligna is native to Western Australia. It has become an introduced and fast-growing plant in other parts of the world due to its ability to adapt to drought, saline and alkaline soils, and hast growing environments. Studies on the bioactiviti
Externí odkaz:
https://doaj.org/article/4e52534300bb44ecb64ec81e8b3f8156
Publikováno v:
Molecules, Vol 28, Iss 10, p 4054 (2023)
Our early work indicated that methanolic extracts from the flowers, leaves, bark, and isolated compounds of Acacia saligna exhibited significant antioxidant activities in vitro. The overproduction of reactive oxygen species (ROS) in the mitochondria
Externí odkaz:
https://doaj.org/article/5fa2da55616343429f050bd5096628b0
Publikováno v:
Molecules, Vol 28, Iss 3, p 1028 (2023)
Acacia saligna growing in Australia has not been fully investigated for its bioactive phytochemicals. Sequential polarity-based extraction was employed to provide four different extracts from individual parts of A. saligna. Bioactive extracts were de
Externí odkaz:
https://doaj.org/article/b106838ac93e448b9ac3e300d6de4626
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Acquired immunodeficiency syndrome (AIDS) is caused by the Human immunodeficiency virus type-1 (HIV-1). HIV-1 protease (HIV-1 PR) is an essential enzyme for the HIV replication, and therefore, it is an important target for antiret
Externí odkaz:
https://doaj.org/article/f4f2de276e2547efac3ccdf234954f28
Publikováno v:
Molecules, Vol 27, Iss 19, p 6667 (2022)
A novel 4-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-1,2,4-triazole-3,5-dione (5a) was synthesised as a potential [18F]radio-prosthetic group for radiolabelling peptides and proteins via selective bioconjugation with the phenolic side chains of tyrosine
Externí odkaz:
https://doaj.org/article/c7dbec8f33bb437381516c0c2062e3bd
Autor:
Andrew T. King, Hugh G. Hiscocks, Lidia Matesic, Mohan Bhadbhade, Roger Bishop, Alison T. Ung
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1347-1354 (2019)
The one-pot reaction of 2,6-bis(diphenylmethyl)-4-methoxyaniline with tert-butylnitrite, BTEAC and DABSO in the presence of CuCl2 provided an unexpected 3H-indazole product 8. The structure of the compound was determined by HRMS, IR, NMR and further
Externí odkaz:
https://doaj.org/article/5749363b49d24e89b0f9811125cb766f