Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alison S Salvatori"'
Autor:
Wieke Freudenburg, Madhav Gautam, Pradipta Chakraborty, Jared James, Jennifer Richards, Alison S Salvatori, Aaron Baldwin, Jill Schriewer, R Mark L Buller, John A Corbett, Dorota Skowyra
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e52408 (2013)
Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with th
Externí odkaz:
https://doaj.org/article/ce511bb44e184cc4a11634b4d99f5488
Autor:
Mollisa M. Elrick, Lauren M. Stein, John A. Corbett, Willis K. Samson, Grant R. Kolar, Gina L. C. Yosten, Alison S. Salvatori
Publikováno v:
Physiology & Behavior. 162:147-150
Insulin-dependent individuals with diabetes are at risk for a severe hypoglycemic event that may predispose them to several repeat episodes during which the normal counter regulatory mechanisms that protect against hypoglycemia fail to be activated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3c54dc167007c238d2fa7989672848
https://doi.org/10.1016/j.physbeh.2016.04.012
https://doi.org/10.1016/j.physbeh.2016.04.012
Autor:
Gina L. C. Yosten, Aaron Naatz, John A. Corbett, Grant R. Kolar, Willis K. Samson, Alison S. Salvatori, Lauren M. Stein, Mollisa M. Elrick
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 310:R143-R155
Neuronostatin (NST) is a recently described peptide that is produced from the somatostatin preprohormone in pancreatic δ-cells. NST has been shown to increase glucagon secretion from primary rat pancreatic islets in low-glucose conditions. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a778ba39b30a4c868189deb80e4ed95b
https://doi.org/10.1152/ajpregu.00369.2014
https://doi.org/10.1152/ajpregu.00369.2014
Publikováno v:
Diabetes
OBJECTIVE Glucose-stimulated islet insulin or C-peptide secretion experiments are a fundamental tool for studying and assessing islet function. The goal of this work was to develop Ab-based fluorescent homogenous sensors that would allow rapid, inexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848def354166fe270ab392da315216c6
https://doi.org/10.2337/db10-0088
https://doi.org/10.2337/db10-0088
Autor:
Gordon P. Meares, Katherine J. Hughes, Christopher J. Rhodes, Kimberly F. Jaimes, Alison S. Salvatori, John A. Corbett
Publikováno v:
Journal of Biological Chemistry. 285:3191-3200
During the initial autoimmune response in type 1 diabetes, islets are exposed to a damaging mix of pro-inflammatory molecules that stimulate the production of nitric oxide by beta-cells. Nitric oxide causes extensive but reversible cellular damage. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d0241cdd95b565c804aa83a381af43
https://doi.org/10.1074/jbc.m109.047365
https://doi.org/10.1074/jbc.m109.047365
Autor:
Lauren M. Stein, Alison S. Salvatori, Gina L. C. Yosten, Grant R. Kolar, Mollisa M. Elrick, Jun Ren, John A. Corbett, Willis K. Samson
The Human Genome Project provided the opportunity to use bioinformatic approaches to discover novel, endogenous hormones. Using this approach we have identified two novel peptide hormones and review here our strategy for the identification and charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb1354f3ab1276415f332201510a44c
https://europepmc.org/articles/PMC4641813/
https://europepmc.org/articles/PMC4641813/
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 306(11)
Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011da67c8e96694052f492830a1d629f
https://pubmed.ncbi.nlm.nih.gov/24735892
https://pubmed.ncbi.nlm.nih.gov/24735892
Publikováno v:
The FASEB Journal. 28
Neuronostatin (NST) is produced in pancreatic delta cells from the somatostatin preprohormone, and has been shown to inhibit glucose-stimulated insulin secretion from beta cells of primary islets, but not from isolated beta cell cultures. We have dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bbc7be3c59af0df537e6aed7a8d16c6
https://doi.org/10.1096/fasebj.28.1_supplement.1108.3
https://doi.org/10.1096/fasebj.28.1_supplement.1108.3
Autor:
Aaron C. Baldwin, Pradipta Chakraborty, Dorota Skowyra, Wieke Freudenburg, R. Mark L. Buller, Madhav Gautam, Jennifer P. Richards, Alison S. Salvatori, Jill Schriewer, John A. Corbett, Jared James
Publikováno v:
Journal of clinicalcellular immunology. 4(2)
Type 1 diabetes results from autoimmune destruction of the insulin producing pancreatic β-cells. The immunoproteasome, a version of the proteasome that collaborates with the 11S/PA28 activator to generate immunogenic peptides for presentation by MHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a7c675f7c8f61d60d671d2b0d1cdf6
https://pubmed.ncbi.nlm.nih.gov/23956946
https://pubmed.ncbi.nlm.nih.gov/23956946
Autor:
Steven E. Shoelson, Gordon C. Weir, Jennifer Hollister-Lock, Yongjing Guo, Brooke Morris, Susan Bonner-Weir, Dongsheng Cai, John A. Corbett, Alison S. Salvatori, Aileen King
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77452 (2013)
King, A J F, Guo, Y, Cai, D, Hollister-Lock, J, Morris, B, Salvatori, A, Corbett, J A, Bonner-Weir, S, Shoelson, S E & Weir, G C 2013, ' Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes ', PL o S One, vol. 8, no. 10, e77452 . https://doi.org/10.1371/journal.pone.0077452
PLoS ONE
King, A J F, Guo, Y, Cai, D, Hollister-Lock, J, Morris, B, Salvatori, A, Corbett, J A, Bonner-Weir, S, Shoelson, S E & Weir, G C 2013, ' Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes ', PL o S One, vol. 8, no. 10, e77452 . https://doi.org/10.1371/journal.pone.0077452
PLoS ONE
The activation of the transcription factor NF-κB leads to changes in expression of many genes in pancreatic β-cells. However, the role of NF-κB activation in islet transplantation has not been fully elucidated. The aim of the present study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c760a7d4df2bd04d0f40ffdceddcf76
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204831/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204831/pdf/?tool=EBI