Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Alison Roos"'
Autor:
Mylan R. Blomquist, Ryan Eghlimi, Angad Beniwal, Dustin Grief, David G. Nascari, Landon Inge, Christopher P. Sereduk, Serdar Tuncali, Alison Roos, Hannah Inforzato, Ritin Sharma, Patrick Pirrotte, Shwetal Mehta, Shannon P. Fortin Ensign, Joseph C. Loftus, Nhan L. Tran
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6279 (2024)
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with few effective treatments. EGFR alterations, including expression of the truncated variant EGFRvIII, are among the most frequent genomic changes in these tumors. EGFRv
Externí odkaz:
https://doaj.org/article/f44d13bf32f84893b0f046234c83c2ca
Autor:
Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy, Minjee Kim, Alison Roos, David Calligaris, Michael S. Regan, Shiv K. Gupta, Ann C. Mladek, Brett L. Carlson, Aaron J. Johnson, Fa-Ke Lu, X. Sunney Xie, Brian A. Joughin, Raven J. Reddy, Sen Peng, Walid M. Abdelmoula, Pamela R. Jackson, Aarti Kolluri, Katherine A. Kellersberger, Jeffrey N. Agar, Douglas A. Lauffenburger, Kristin R. Swanson, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y. R. Agar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib,
Externí odkaz:
https://doaj.org/article/17219987055045cbbd74e20d4356a523
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults with a 5-year survival rate of 5% despite intensive research efforts. The poor prognosis is due, in part, to aggressive invasion into the surrounding brain parenchyma. I
Externí odkaz:
https://doaj.org/article/6070e5cece874593939a1061737d334a
Autor:
Alison Roos, Lucio Gordan, Michael Diaz, Anjan Patel, Matthew Fink, David Wenk, John Jiang, Janice Tam, Pratheesh Sathyan, Phil Febbo
Publikováno v:
Journal of the National Comprehensive Cancer Network. 21:CGE23-073
Autor:
Joseph C. Loftus, Nhan L. Tran, Jennifer M. Eschbacher, Patrick Pirrotte, Sen Peng, Harshil Dhruv, Jean Kloss, Alison Roos, Zonghui Ding
Glioblastoma is the most frequent primary brain tumor in adults and a highly lethal malignancy with a median survival of about 15 months. The aggressive invasion of the surrounding normal brain makes complete surgical resection impossible, increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ff3fb6babe47fcb78e158efbd39933
https://doi.org/10.1158/1541-7786.c.6540342
https://doi.org/10.1158/1541-7786.c.6540342
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 6. SGEF protein levels across a panel of primary parental versus TMZ-R xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4611b39fd6f3970f0abc32476f9187
https://doi.org/10.1158/1541-7786.22511431
https://doi.org/10.1158/1541-7786.22511431
Autor:
Nhan L. Tran, Jeffrey A. Winkles, Joseph C. Loftus, Jennifer M. Eschbacher, Zachary Mayo, Nghia Millard, Michael Pineda, Serdar Tuncali, Landon J. Inge, Sen Peng, Harshil D. Dhruv, Alison Roos
Specificity of siRNAs targeting Stat isoforms in GBM cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864260ffbb1811c3dd6ba23d388b8121
https://doi.org/10.1158/1541-7786.22513464
https://doi.org/10.1158/1541-7786.22513464
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Glioblastoma (GB) is the highest grade and most common form of primary adult brain tumors. Despite surgical removal followed by concomitant radiation and chemotherapy with the alkylating agent temozolomide, GB tumors develop treatment resistance and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391a81596584efe054a2285399ced34c
https://doi.org/10.1158/1541-7786.c.6539941.v1
https://doi.org/10.1158/1541-7786.c.6539941.v1
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 1. Depletion of SGEF expression does not alter glioma cell proliferation or cell cycle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6af9b553a070be890d5ac78ce4e604
https://doi.org/10.1158/1541-7786.22511446
https://doi.org/10.1158/1541-7786.22511446
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 4. TMZ treatment induces nuclear RhoG activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9f16a3e56a257bb187dea79f8f9bcd
https://doi.org/10.1158/1541-7786.22511437
https://doi.org/10.1158/1541-7786.22511437