Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Alison N. Hulme"'
Publikováno v:
Heritage, Vol 6, Iss 5, Pp 4042-4053 (2023)
Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient mass spectrometry technique that shows great potential for the analysis of fragile heritage objects in situ. This article focuses on the application of a recently built DESI
Externí odkaz:
https://doaj.org/article/53000f40f5cd4a8d89924039d0e45e4a
Publikováno v:
Molecules, Vol 26, Iss 19, p 6035 (2021)
Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling. However, synthetic methodology for the spiro-funct
Externí odkaz:
https://doaj.org/article/59f2140d31e54e58af8ae020bd7daeda
Autor:
Richard C. Brewster, Alison N. Hulme
Publikováno v:
Molecules, Vol 26, Iss 18, p 5461 (2021)
Post-translational modifications (PTMs) are used by organisms to control protein structure and function after protein translation, but their study is complicated and their roles are not often well understood as PTMs are difficult to introduce onto pr
Externí odkaz:
https://doaj.org/article/68691866d9b3490abcb4969e99b9992d
Autor:
Sally Vanden-Hehir, William J. Tipping, Martin Lee, Valerie G. Brunton, Anna Williams, Alison N. Hulme
Publikováno v:
Nanomaterials, Vol 9, Iss 3, p 341 (2019)
The efficacy of pharmaceutical agents can be greatly improved through nanocarrier delivery. Encapsulation of pharmaceutical agents into a nanocarrier can enhance their bioavailability and biocompatibility, whilst also facilitating targeted drug deliv
Externí odkaz:
https://doaj.org/article/499787a7d8ae4d95996eb2bde2761b10
Autor:
Jill R. Hanna, Christopher Allan, Charlotte Lawrence, Odile Meyer, Neil D. Wilson, Alison N. Hulme
Publikováno v:
Molecules, Vol 22, Iss 5, p 802 (2017)
The CuAAC ‘click’ reaction was used to couple alkyne-functionalized lanthanide-DOTA complexes to a range of fluorescent antennae. Screening of the antenna components was aided by comparison of the luminescent output of the resultant sensors using
Externí odkaz:
https://doaj.org/article/4e7c4ad53ea644c4805033aad5ccdc3c
Autor:
David Georgiev, Bartholomeus W. H. Saes, Heather J. Johnston, Sarah K. Boys, Alan Healy, Alison N. Hulme
Publikováno v:
Molecules, Vol 21, Iss 1, p 88 (2016)
The mono ortho-bromination of phenolic building blocks by NBS has been achieved in short reaction times (15–20 min) using ACS-grade methanol as a solvent. The reactions can be conducted on phenol, naphthol and biphenol substrates, giving yields of
Externí odkaz:
https://doaj.org/article/75fbe2624b844058a5a5729029db62e9
Autor:
Valerie Brunton, Martin Lee, Ander Maguregui, Craig Steven, Manasa Ravindra, Romain B. Enjalbert, Michaela Noskova, Steve Hood, Alison N. Hulme, Miguel O. Bernabeu
Publikováno v:
Advanced Chemical Microscopy for Life Science and Translational Medicine 2023.
Autor:
Craig F. Steven, Manasa Punaha-Ravindra, Martin Lee, William Brownlee, Paul Davey, Elisabetta Chiarparin, Valerie G. Brunton, Alison N. Hulme
Publikováno v:
Visualizing and Quantifying Drug Distribution in Tissue VII.
Publikováno v:
Sandström, E, Vettorazzo, C, Mackay, C L, Troalen, L G & Hulme, A N 2023, ' Development and Application of Desorption Electrospray Ionization Mass Spectrometry for Historical Dye Analysis ', Analytical Chemistry . https://doi.org/10.1021/acs.analchem.2c03281
A desorption electrospray ionization (DESI) source was built and attached to a Bruker 7T SolariX FT-ICR-MS for the in situ analysis of 14 early synthetic dyestuffs. Optimization using silk and wool cloths dyed with rhodamine B concluded that when usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a138136ef65ec67a4cb1d67421a4fbb
https://hdl.handle.net/20.500.11820/aca05b86-24be-4f8c-9ce0-d8fab8d13359
https://hdl.handle.net/20.500.11820/aca05b86-24be-4f8c-9ce0-d8fab8d13359
Publikováno v:
Angewandte Chemie (International Ed. in English)
Yiannakas, E, Grimes, M, Whitelegge, J, Fürstner, A & Hulme, A N 2021, ' An Alkyne Metathesis Based Approach to the Synthesis of the Anti-malarial Macrodiolide Samroiyotmycin A ', Angewandte Chemie International Edition . https://doi.org/10.1002/anie.202105732
Yiannakas, E, Grimes, M, Whitelegge, J, Fürstner, A & Hulme, A N 2021, ' An Alkyne Metathesis Based Approach to the Synthesis of the Anti-malarial Macrodiolide Samroiyotmycin A ', Angewandte Chemie International Edition . https://doi.org/10.1002/anie.202105732
We report the first total synthesis of samroiyotmycin A (1), a C2‐symmetric 20‐membered anti‐malarial macrodiolide isolated from Streptomyces sp. The convergent synthetic strategy orchestrates bisalkyne fragment‐assembly using an unprecedente