Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alison Mbekeani"'
Autor:
J. Steele, B. Kebede, C. Regnault, S.K. Wrigley, Michael P. Barrett, Lynn Evans, Paul W. Denny, Alison Mbekeani, J. Elliot, R.S. Jones, M. Bassas Llorens
Publikováno v:
International journal for parasitology : drugs and drug resistance, 2019, Vol.11, pp.118-128 [Peer Reviewed Journal]
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss, Pp 118-128 (2019)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss, Pp 118-128 (2019)
Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the World's poorest, however vaccines are absent and drug therapy limited. Recently, public-private
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f72ead6f3f9f17e76bb40edd4b2fcff
http://dro.dur.ac.uk/28513/
http://dro.dur.ac.uk/28513/
Autor:
Katie J. Ewer, Tom Ford, Jill Gilmour, Nicola Winstone, Len Dally, Claire Wenden, Josephine H. Cox, Alison Mbekeani, Merribeth Morin, Adrian V. S. Hill
Publikováno v:
Vaccine
Ex vivo functional immunoassays such as ELISpot and intracellular cytokine staining (ICS) by flow cytometry are crucial tools in vaccine development both in the identification of novel immunogenic targets and in the immunological assessment of sample
Publikováno v:
Parasitology, 2018, Vol.145(2), pp.148-155 [Peer Reviewed Journal]
SUMMARYToxoplasma gondiiis an obligate intracellular protozoan parasite of the phylum Apicomplexa, and toxoplasmosis is an important disease of both humans and economically important animals. With a limited array of drugs available there is a need to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa86dce8d00ccf489e9203f6a81f1d4c
http://dro.dur.ac.uk/21777/1/21777.pdf
http://dro.dur.ac.uk/21777/1/21777.pdf
Autor:
Paul M. O'Neill, Alison Mbekeani, Janet Hemingway, Giancarlo A. Biagini, Neil G. Berry, Alison E. Shone, Richard Amewu, Michael J. Delves, Bénédicte Pacorel, Nicholas Fisher, Chandrakala Pidathala, Suet C. Leung, David W. Hong, Robert E. Sinden, James Chadwick, Jill Davies, Murad A. Mubaraki, Gemma L. Nixon, Raman Sharma, Thomas Antoine, Stephen A. Ward, Alisdair Hill, Alexandre S. Lawrenson, Sitthivut Charoensutthivarakul, Abhishek Srivastava, Olivier Berger, Clemens H. M. Kocken, Lee Taylor, Ashley J. Warman, Paul A. Stocks, Anne-Marie Zeeman, Peter Gibbons
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8298-8303
There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during t
Autor:
Alasdair Hill, Peter Gibbons, Alison E. Shone, David William Cronk, Gemma L. Nixon, Stephen A. Ward, Chandrakala Pidathala, David W. Hong, Ian K. Gowers, Richard Amewu, Alison Mbekeani, Raman Sharma, Joanne Lesley Shearer, Serge P. Parel, Alexandre S. Lawrenson, Giancarlo A. Biagini, Paul A. Stocks, Ashley J. Warman, Paul M. O'Neill, Suet C. Leung, James Chadwick, Nicholas Fisher, Neil G. Berry
Publikováno v:
Journal of Medicinal Chemistry
Malaria is responsible for approximately 1 million deaths annually; thus, continued efforts to discover new antimalarials are required. A HTS screen was established to identify novel inhibitors of the parasite's mitochondrial enzyme NADH:quinone oxid
Autor:
Suet C. Leung, Peter Gibbons, Richard Amewu, Gemma L. Nixon, Chandrakala Pidathala, W. David Hong, Bénédicte Pacorel, Neil G. Berry, Raman Sharma, Paul A. Stocks, Abhishek Srivastava, Alison E. Shone, Sitthivut Charoensutthivarakul, Lee Taylor, Olivier Berger, Alison Mbekeani, Alasdair Hill, Nicholas E. Fisher, Ashley J. Warman, Giancarlo A. Biagini, Stephen A. Ward, Paul M. O’Neill
Publikováno v:
Journal of Medicinal Chemistry
Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule s
Autor:
Abhishek Srivastava, Suet C. Leung, Neil G. Berry, Paul M. O'Neill, Richard Amewu, Alison Mbekeani, Alison E. Shone, Olivier Berger, Gemma L. Nixon, Sitthivut Charoensutthivarakul, Stephen A. Ward, Paul A. Stocks, W. David Hong, Bénédicte Pacorel, Alasdair Hill, Nicholas Fisher, Raman Sharma, Chandrakala Pidathala, Peter Gibbons, Giancarlo A. Biagini, Lee Taylor, Ashley J. Warman
Publikováno v:
Journal of Medicinal Chemistry
A program was undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a dehydrogenase of the mitochondrial electron transport chain of the malaria parasite Plasmodium falciparum. PfNDH2 has only one known inhibitor, hydr
Autor:
Louise Le Pensee, Ashley J. Warman, Richard Amewu, Alison E. Shone, Alison Mbekeani, David W. Hong, Alasdair Hill, Steve A. Ward, Peter Gibbons, Neil G. Berry, Nicholas Fisher, Gemma L. Nixon, Chandra Pidathala, Giancarlo A. Biagini, Raman Sharma, Victoria Barton, Paul A. Stocks, James Chadwick, Paul M. O'Neill
Publikováno v:
Malaria Journal
NADH:quinone oxidoreductase (PfNDH2) represents a metabolic choke point in the respiratory chain of Plasmodium falciparum mitochondria and is the focus of a drug discovery programme. A miniaturised assay for recombinant PfNDH2 with robust assay perfo
Autor:
Alasdair Hill, Peter Gibbons, Paul M. O'Neill, Alison E. Shone, David W. Hong, James Chadwick, Giancarlo A. Biagini, Ashley J. Warman, Gemma L. Nixon, Chandra Pidathala, Paul A. Stocks, Raman Sharma, Victoria Barton, Neil G. Berry, Nicholas Fisher, Steve A. Ward, Louise Le Pensee, Richard Amewu, Alison Mbekeani
Publikováno v:
Malaria Journal
Malaria Journal, Vol 9, Iss Suppl 2, p I14 (2010)
Europe PubMed Central
Malaria Journal, Vol 9, Iss Suppl 2, p I14 (2010)
Europe PubMed Central
The mitochondrial respiratory chain of the malaria parasite Plasmodium falciparum differs from that of its human host in that it lacks a canonical protonmotive NADH:ubiquinone oxidoreductase (Complex I), containing instead a single sub-unit, non-prot