Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Alison M. Nagle"'
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Data from Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors
Autor: Adrian V. Lee, Steffi Oesterreich, Jennifer M. Atkinson, Britta M. Jacobsen, David N. Boone, Tiffany A. Katz, Justin Kehm, Kara Burlbaugh, Julie A. Scott, Nilgun Tasdemir, Kevin M. Levine, Alison M. Nagle
Purpose: Insulin-like growth factor 1 (IGF1) signaling regulates breast cancer initiation and progression and associated cancer phenotypes. We previously identified E-cadherin (CDH1) as a repressor of IGF1 signaling and in this study examined how los
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005cff436545594f4b6949e671d4ce94
https://doi.org/10.1158/1078-0432.c.6529136
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4
Abstract 2690: Loss of E-cadherin induces IGF1R activation revealing a targetable pathway in invasive lobular breast carcinoma
Autor: Ashuvinee Elangovan, Laura Savariau, Megan E. Yates, Jagmohan Hooda, Alison M. Nagle, Steffi Oesterreich, Jennifer M. Atkinson, Adrian V. Lee
Publikováno v: Cancer Research. 82:2690-2690
Invasive Ductal Carcinoma (IDC) and Invasive Lobular Carcinoma (ILC) are two major subtypes of breast cancer with significant differences in their histological and molecular underpinnings. ILC has a unique loss of E-cadherin (CDH1) which we have prev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68b7eaf16eb79b97ebcf8f058c5cce04
https://doi.org/10.1158/1538-7445.am2022-2690
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5
Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors
Autor: Alison M. Nagle, David N. Boone, Adrian V. Lee, Tiffany A. Katz, Britta M. Jacobsen, Nilgun Tasdemir, Kara Burlbaugh, Steffi Oesterreich, Julie A. Scott, Jennifer M. Atkinson, Kevin M. Levine, Justin W Kehm
Publikováno v: Clinical Cancer Research. 24:5165-5177
Purpose: Insulin-like growth factor 1 (IGF1) signaling regulates breast cancer initiation and progression and associated cancer phenotypes. We previously identified E-cadherin (CDH1) as a repressor of IGF1 signaling and in this study examined how los
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c8f827a0391bb1d14d4ba51d772f4e
https://doi.org/10.1158/1078-0432.ccr-18-0279
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7
Tumor mutational burden and other predictive immunotherapy markers in histiocytic neoplasms
Autor: Alison M. Nagle, Karen L. Rech, N. Nora Bennani, Ronald S. Go, Jay H. Ryu, Robert Vassallo, W. Oliver Tobin, Mithun Vinod Shah, Gaurav Goyal, Matthew J. Koster, Denise Lau, Minetta C. Liu, Caroline J. Davidge-Pitts
TO THE EDITOR: Histiocytic neoplasms are rare hematological disorders that have diverse clinical manifestations and can pose significant management challenges for clinicians. Previously considered inflammatory, several of these disorders are now incl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee078817946d7fb48cb1ab7721952c3
https://europepmc.org/articles/PMC6911819/
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8
Abstract PD2-08: Potential role of prolactin signaling in development and growth of the lobular subtype of breast cancer
Autor: Tiffany A. Katz, George C. Tseng, G. J. Logan, H Rui, Adrian V. Lee, Lesley M. Butler, Zhiguang Huo, Alison M. Nagle, Kevin M. Levine, Steffi Oesterreich
Publikováno v: Cancer Research. 76:PD2-08
Invasive lobular carcinoma (ILC) is the eighth most frequently diagnosed cancer in any organ, and accounts for 8-11% of breast cancer. This histological subtype is characterized by loss of E-cadherin, and favorable prognostic factors, such as low Ki6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45b50d72263e0828b003d943ff77647e
https://doi.org/10.1158/1538-7445.sabcs15-pd2-08
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9
Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R inhibitors
Autor: David N. Boone, Nilgun Tasdemir, Adrian V. Lee, Alison M. Nagle, Tiffany A. Katz, Kara Burlbaugh, Justin W Kehm, Julie A. Scott, Britta M. Jacobsen, Steffi Oesterreich, Jennifer M. Atkinson, Kevin M. Levine
PurposeInsulin-like growth factor I (IGF1) signaling regulates breast cancer initiation and progression and associated cancer phenotypes. We previously identified E-cadherin (CDH1) as a repressor of IGF1 signaling and in this study examined how loss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3d912e77b9eb4133111efafdcf210a
https://doi.org/10.1101/253278
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10
Dietary supplementation of β-guanidinopropionic acid (βGPA) reduces whole-body and skeletal muscle growth in young CD-1 mice
Autor: Stephen T. Kinsey, A. Elaine Farmer, Alison M. Nagle, Bradley L. Baumgarner, Meagan R. Quinn
Publikováno v: Molecular and Cellular Biochemistry. 403:277-285
Increased AMP-activated protein kinase (AMPK) activity leads to enhanced fatty acid utilization, while also promoting increased ubiquitin-dependent proteolysis (UDP) in mammalian skeletal muscle. β-guanidinopropionic acid (βGPA) is a commercially a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e52cd76de43f5d2517c34ea119ba70
https://doi.org/10.1007/s11010-015-2357-7
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