Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Alison M. Leese"'
Autor:
Jill M Brooks, Heather M Long, Rose J Tierney, Claire Shannon-Lowe, Alison M Leese, Martin Fitzpatrick, Graham S Taylor, Alan B Rickinson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005549 (2016)
Epstein-Barr virus, a B-lymphotropic herpesvirus, is the cause of infectious mononucleosis, has strong aetiologic links with several malignancies and has been implicated in certain autoimmune diseases. Efforts to develop a prophylactic vaccine to pre
Externí odkaz:
https://doaj.org/article/1dfc125317dd48d1bfb10be0d65fcd47
Autor:
Shamanthi Jayasooriya, Thushan I de Silva, Jainaba Njie-jobe, Chilel Sanyang, Alison M Leese, Andrew I Bell, Karen A McAulay, Peng Yanchun, Heather M Long, Tao Dong, Hilton C Whittle, Alan B Rickinson, Sarah L Rowland-Jones, Andrew D Hislop, Katie L Flanagan
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004746 (2015)
Epstein-Barr virus (EBV) infection often occurs in early childhood and is asymptomatic. However, if delayed until adolescence, primary infection may manifest as acute infectious mononucleosis (AIM), a febrile illness characterised by global CD8+ T-ce
Externí odkaz:
https://doaj.org/article/9f7656ff746e49acba6b99d0dc0a6fc4
Autor:
Eddie A. James, Alison M. Leese, Gordon B. Ryan, James E. McLaren, Kristin Ladell, David Price, Benjamin J Meckiff, Heather M. Long
Publikováno v:
The Journal of Immunology Author Choice
Key Points Primary EBV infection drives highly cytotoxic virus-specific CD4+ T cell responses. EBV-specific memory CD4+ T cells are polyfunctional but lack cytotoxic activity. Acute EBV-specific CD4-CTLs differ transcriptionally from classical memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd6d641576b4d5c842ef1b072a560d0
https://doi.org/10.4049/jimmunol.1900377
https://doi.org/10.4049/jimmunol.1900377
Autor:
Rachel J, Abbott, Annette, Pachnio, Isabela, Pedroza-Pacheco, Alison M, Leese, Jusnara, Begum, Heather M, Long, Debbie, Croom-Carter, Andrea, Stacey, Paul A H, Moss, Andrew D, Hislop, Persephone, Borrow, Alan B, Rickinson, Andrew I, Bell
Publikováno v:
Journal of Virology
Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. In contrast, infection later in life often leads to infectious mononucleosis (IM), a febrile illness characterized by anti-EBV IgM antibody positivity, high loads of circul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97ad1248a9c330a8a3f0e355420a780b
https://pubmed.ncbi.nlm.nih.gov/28835490
https://pubmed.ncbi.nlm.nih.gov/28835490
Autor:
Alan B. Rickinson, Odette Chagoury, Rachel J. M. Abbott, Shereen Sabbah, Alison M. Leese, Heather M. Long, Eddie A. James, William W. Kwok, Gordon B. Ryan, Laura T. Morton
Publikováno v:
The Journal of Experimental Medicine
Characterization of the human EBV-specific CD4+ T cell response using MHC II tetramers reveals the latent EBV antigen response is more frequent than the lytic response with a delayed EBNA1 response that coincides with diminished cross-presentation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dcf2fb4db80a556994b8643d69dfcf
http://europepmc.org/articles/PMC3646497
http://europepmc.org/articles/PMC3646497
Autor:
Martin Fitzpatrick, Alan B. Rickinson, Heather M. Long, Graham S. Taylor, Jill Brooks, Rose J. Tierney, Claire Shannon-Lowe, Alison M. Leese
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 4, p e1005549 (2016)
PLoS Pathogens, Vol 12, Iss 4, p e1005549 (2016)
Epstein-Barr virus, a B-lymphotropic herpesvirus, is the cause of infectious mononucleosis, has strong aetiologic links with several malignancies and has been implicated in certain autoimmune diseases. Efforts to develop a prophylactic vaccine to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4333062ba5589d31a7ebd57132dc4713
http://europepmc.org/articles/PMC4838210
http://europepmc.org/articles/PMC4838210
Autor:
Paul Moss, Mike Salmon, Alison M. Leese, Alan Bernard Rickinson, S. John Curnow, Delphine Sauce, Andrew D. Hislop, Martin Larsen
Publikováno v:
Blood. 108:11-18
In mice, interleukin-7 (IL-7) and IL-15 are involved in T-cell homeostasis and the maintenance of immunologic memory. Here, we follow virus-induced responses in infectious mononucleosis (IM) patients from primary Epstein-Barr virus (EBV) infection in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf05fee11d980db9492644ba179c8e1
https://doi.org/10.1182/blood-2006-01-0144
https://doi.org/10.1182/blood-2006-01-0144
Publikováno v:
The Journal of Experimental Medicine
Antigen immunodominance is an unexplained feature of CD8+ T cell responses to herpesviruses, which are agents whose lytic replication involves the sequential expression of immediate early (IE), early (E), and late (L) proteins. Here, we analyze the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c814a586eb61ff2ae22715c7f6de73d7
http://europepmc.org/articles/PMC2213038
http://europepmc.org/articles/PMC2213038
Autor:
Jens Kuhle, Sofia Sisay, Alan B. Rickinson, Gavin Giovannoni, Jusnara Begum, Annette Pachnio, Caren Ramien, Sreeram V. Ramagopalan, Paul Moss, Ute-Christiane Meier, Giulio Disanto, Alison M. Leese
Publikováno v:
Multiple Sclerosis Journal. 20:751-753
Late Epstein-Barr virus infection and hypovitaminosis-D as environmental risk factors in the pathogenesis of multiple sclerosis are gaining great interest. We, therefore, tested for in-vivo interdependence between Epstein-Barr-virus (EBV)-status and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a204b37aade2e17463db426dd114da05
https://doi.org/10.1177/1352458513509507
https://doi.org/10.1177/1352458513509507
Publikováno v:
The Journal of Experimental Medicine
Primary virus infection often elicits a large CD8(+) T cell response which subsequently contracts to a smaller memory T cell pool; the relationship between these two virus-specific populations is not well understood. Here we follow the human CD8(+) T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb1be5af28b9b27c73b10c25e0900b6
https://doi.org/10.1084/jem.20011692
https://doi.org/10.1084/jem.20011692