Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Alison M. Bendele"'
Autor:
Erik Lindström, Biljana Rizoska, Karin Tunblad, Charlotte Edenius, Alison M. Bendele, Don Maul, Michael Larson, Neha Shah, Valerie Yoder Otto, Chris Jerome, Urszula Grabowska
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to anterior cruciate ligament transection (ACLT), and the pr
Externí odkaz:
https://doaj.org/article/091b4e96d00f43a7a8556bd402944cd7
Autor:
Daniel E. Lieberman, Nicholas B. Holowka, Tyson L. Hedrick, Nicolai Konow, Ian J. Wallace, Daniel J. Brooks, Rebecca Landau, Grant J. Riew, Alison M. Bendele
Publikováno v:
American Journal of Biological Anthropology. 177:223-231
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b5e644689c19e1f836674e1fd73c35
https://doi.org/10.1002/ajpa.24429
https://doi.org/10.1002/ajpa.24429
Publikováno v:
Eur J Med Chem
Osteoarthritis (OA) is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Current treatments for OA primarily involve providing only relief of symptoms but doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b33d233202a127308fc5fbf12da2ed8
https://europepmc.org/articles/PMC8511113/
https://europepmc.org/articles/PMC8511113/
Autor:
Benjamin A. Lakin, Benjamin G. Cooper, Mark W. Grinstaff, Brian D. Snyder, Alison M. Bendele, Michel Wathier, Jonathan D. Freedman, Luai Zakaria, Daniel J. Grasso
Publikováno v:
ACS Biomaterials Science & Engineering. 5:3060-3067
A poly(7-oxanorbornene-2-carboxylate) polymer containing pendent triethyleneglycol (TEG) chains of 2.8 MDa (“2.8M TEG”) was synthesized and evaluated for long-term lubrication and wear reduction of ex vivo bovine cartilage as well as for synoviti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b75f9d49b2fecf8d7698f073a827f8
https://doi.org/10.1021/acsbiomaterials.9b00085
https://doi.org/10.1021/acsbiomaterials.9b00085
Autor:
Armaghan Emami, Jeff Tepper, Jay H Chang, Alvaro F Cisternas, R. Daniel Mellon, Tony L. Yaksh, Alison M Bendele, Brian Short, Thulasi Ramani
Publikováno v:
International journal of toxicology, vol 37, iss 1
As the need for nasal, ocular, spinal, and articular therapeutic compounds increases, toxicology assessments of drugs administered via these routes play an important role in human safety. This symposium outlined the local and systemic evaluation to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5242a93f06634924701839e8c257eb1
https://doi.org/10.1177/1091581817741840
https://doi.org/10.1177/1091581817741840
Autor:
Sarah M. Y. Ng, Andrew Craig Donohue, Adrian Sulistio, Cindy C. Shu, John F. Quinn, Stephen Lonsdale Birkett, Michael R. Whittaker, Thomas P. Davis, David Valade, Christopher B. Little, Anton Blencowe, Alison M. Bendele, Friederike M. Mansfeld, Asha M. D’Souza, Felisa Reyes-Ortega, Russell John Tait, Greg G. Qiao
The most common treatment for osteoarthritis is daily oral administration of a nonsteroidal anti-inflammatory drug such as diclofenac. This daily dosage regime is often associated with severe side effects. In this study, we explored the potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a30b61e9ea86a32c81bda06881c0240
https://hdl.handle.net/11541.2/138572
https://hdl.handle.net/11541.2/138572
Autor:
Kathryn E. Gropp, Lonnie E Grantham, Alison M. Bendele, Brian C Omura, David L. Shelton, Mark Zorbas, Susan Hurst, Thomas Cummings, Cedo M. Bagi, Timothy P. LaBranche
Publikováno v:
Annals of the Rheumatic Diseases
ObjectiveTo investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials.MethodsMale Lewis rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a6c55a59479fe9827aa22658df7c41
https://doi.org/10.1136/annrheumdis-2015-208913
https://doi.org/10.1136/annrheumdis-2015-208913
Autor:
Karensa L. Douglas, Alison M. Bendele, Alvaro Ortiz, Brandee Wagner, Xueqing Liu, Ken Song, Connor Ohlsen, Nicholas R. Smith, Sole Gatto, Melissa Walker, Nhin Lu, Adam Pavlicek, Robert O'Connell, Jing Qian, Steve Govek, Kyoung-Jin Lee, Pauline Chai, Douglas Zook, Johnny Y. Nagasawa, Angelica Milik
Publikováno v:
Gastroenterology. 158:S-159
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd2a2f4e9195c6ac1fb4639f528d2e2
https://doi.org/10.1016/s0016-5085(20)31085-4
https://doi.org/10.1016/s0016-5085(20)31085-4
Autor:
Kyoung-Jin Lee, Douglas Zook, Johnny Y. Nagasawa, Angelica Milik, Steve Govek, Pauline Chai, Brandee Wagner, Ken Song, Robert O'Connell, Connor Ohlsen, Xueqing Liu, Jing Qian, Karensa L. Douglas, Alison M. Bendele, Alvaro Ortiz, Nicholas R. Smith, Nhin Lu, Melissa Walker
Publikováno v:
Gastroenterology. 158:S11
Introduction Farnesoid X receptor (FXR) is a ligand-activated nuclear hormone receptor expressed in the gastrointestinal tract, with high expression levels in the intestinal epithelium. Previously we have shown that FXR agonists with sustained activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9b8bf53719b800993a7caa2379e813
https://doi.org/10.1053/j.gastro.2019.11.062
https://doi.org/10.1053/j.gastro.2019.11.062
Autor:
Benjamin A. Lakin, Prashant N. Bansal, Alison M. Bendele, Brian D. Snyder, Benjamin G. Cooper, Michel Wathier, Vahid Entezari, Hideki Suzuki, Mark W. Grinstaff
Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af06e8b465c9df4baa961894fb34a12
https://europepmc.org/articles/PMC6287749/
https://europepmc.org/articles/PMC6287749/