Impairment of Lon-Induced Protection Against the Accumulation of Oxidized Proteins in Senescent Wi-38 Fibroblasts

Autor: Daniela A. Bota, Kelvin J.A. Davies, Jenny K. Ngo, Alison L. Koop, Laura C.D. Pomatto

Publikováno v: Ngo, Jenny K; Pomatto, Laura CD; Bota, Daniela A; Koop, Alison L; & Davies, Kelvin JA. (2011). Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts.. The journals of gerontology. Series A, Biological sciences and medical sciences, 66(11), 1178-1185. doi: 10.1093/gerona/glr145. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/6695c9sw

Oxidative damage to mitochondrial proteins is thought to contribute to the aging process, but the Lon protease normally degrades such proteins. In early-passage WI-38 human lung fibroblasts, Lon expression is rapidly induced during H(2)O(2) stress, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0e9b331dbbe0c8b1873a16a73c6705
https://doi.org/10.1093/gerona/glr145

THE IMMUNOPROTEASOME, THE 20S PROTEASOME, AND THE PA28αβ PROTEASOME REGULATOR ARE OXIDATIVE STRESS‐ADAPTIVE PROTEOLYTIC COMPLEXES

Autor: Gennady Ermak, Kelvin J.A. Davies, Andrew M. Pickering, Tilman Grune, Alison L. Koop, Cheryl Teoh Pimental

Publikováno v: The FASEB Journal. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f0a8ddb146ac2648d34b92177b6aa50
https://doi.org/10.1096/fasebj.24.1_supplement.841.1