Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alison L. Althaus"'
Autor:
Alison L, Althaus, Michael A, Ackley, Gabriel M, Belfort, Steven M, Gee, Jing, Dai, David P, Nguyen, Tatiana M, Kazdoba, Amit, Modgil, Paul A, Davies, Stephen J, Moss, Francesco G, Salituro, Ethan, Hoffmann, Rebecca S, Hammond, Albert J, Robichaud, Michael C, Quirk, James J, Doherty
Publikováno v:
Neuropharmacology
Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABAA receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABAA receptor curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::803df3ac66651e96237254d26cf7e615
https://pubmed.ncbi.nlm.nih.gov/32976892
https://pubmed.ncbi.nlm.nih.gov/32976892
Autor:
Francesco G. Salituro, Gabriel Martinez Botella, James J. Doherty, Rebecca S. Hammond, Alison L. Althaus, Carla Maciag, Albert J. Robichaud, Michael A. Ackley
Publikováno v:
Epilepsy Research. 134:16-25
Despite the availability of multiple antiepileptic drugs (AED), failure to adequately control seizures is a challenge for approximately one third of epilepsy patients, and new therapies with a differentiated mechanism of action are needed. The neuroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ebdf33e1a2544115114f31f08ce039
https://doi.org/10.1016/j.eplepsyres.2017.05.001
https://doi.org/10.1016/j.eplepsyres.2017.05.001
Autor:
Ethan Hoffman, Cecelia E. Jackson, James J. Doherty, John H. McDonough, Carl D. Smith, Albert J. Robichaud, Hilary S. McCarren, Alison L. Althaus, Aymen Alqazzaz, Rebecca S. Hammond
Publikováno v:
Epilepsy & Behavior. 68:22-30
Organophosphorus nerve agents (OPNAs) are irreversible inhibitors of acetylcholinesterase that pose a serious threat to public health because of their use as chemical weapons. Exposure to high doses of OPNAs can dramatically potentiate cholinergic sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d874169c0e40070626c865b31540039
https://doi.org/10.1016/j.yebeh.2016.12.024
https://doi.org/10.1016/j.yebeh.2016.12.024
Dysregulated adult hippocampal neurogenesis occurs in many temporal lobe epilepsy (TLE) models. Most dentate granule cells (DGCs) generated in response to an epileptic insult develop features that promote increased excitability, including ectopic loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a79bdbee0ddb4dc40be97d5e776a10
https://europepmc.org/articles/PMC6750946/
https://europepmc.org/articles/PMC6750946/
Autor:
Paul Davies, Albert J. Robichaud, Ethan Hoffmann, James J. Doherty, Tatiana M. Kazdoba, Amit Modgil, Steven M. Gee, Stephen J. Moss, Rebecca S. Hammond, Gabriel M. Belfort, Alison L. Althaus, David P. Nguyen, Jing Dai, Michael Quirk, Francesco G. Salituro, Michael A. Ackley
Publikováno v:
Neuropharmacology. 181:108333
Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABAA receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABAA receptor curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99890c8b94a6266c6c6c30159fa25bcf
https://doi.org/10.1016/j.neuropharm.2020.108333
https://doi.org/10.1016/j.neuropharm.2020.108333
Publikováno v:
Journal of Neurophysiology. 113:1184-1194
Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3651eba0c1de992bd1f5ec1682c229
https://doi.org/10.1152/jn.00835.2014
https://doi.org/10.1152/jn.00835.2014
Autor:
Ethan Hoffmann, Carlos M. Loya, Albert J. Robichaud, Boyd L. Harrison, Richard Thomas Beresis, Jing Dai, Gabriel M. Belfort, Alison L. Althaus, Michael A. Ackley, James J. Doherty, Maria-Jesus Blanco, Zhu Bai, Scott J. Grossman, Francesco G. Salituro, Gabriel Martinez Botella
Publikováno v:
Journal of medicinal chemistry. 60(18)
Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series of 5β-nor-19-pregnan-20-one analogues bearing substituted pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92adadab7380c7344ed988b15618ea47
https://pubmed.ncbi.nlm.nih.gov/28753313
https://pubmed.ncbi.nlm.nih.gov/28753313
Autor:
James P. Roach, Leonard M. Sander, Quinton M. Skilling, Alison L. Althaus, Geoffrey G. Murphy, Michal Zochowski
The granule cells born during adult neurogenesis in the dentate gyrus (DG) are thought to be involved in formation of new memory representations. At the same time, they are implicated in exacerbation of the pathology during epilepsy. Moreover, it has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aed7ae04e67104487adb6bfedf0c06bf
https://doi.org/10.1016/b978-0-12-803784-3.00019-6
https://doi.org/10.1016/b978-0-12-803784-3.00019-6
Autor:
James B. Aimone, Alison L. Althaus, Rosanna C. Barnard, Suzanna Becker, Luc Berthouze, Panagiotis Bozelos, Craig E. Brown, Markus Butz-Ostendorf, Kristofor D. Carlson, Hermann Cuntz, Will DeBello, Gustavo Deco, Moritz Deger, Thomas Deller, Simon F. Farmer, Michael Fauth, Henrique M. Fernandes, Rory Finnegan, Tomoki Fukai, Shaoyu Ge, Kimberly Gerrow, Keren Grafen, Naoki Hiratani, Felix Z. Hoffmann, Anthony Holtmaat, Frances Hutchings, Peter Jedlicka, Marcus Kaiser, Vassilis Kehayas, Gregory W. Kirschen, Istvan Z. Kiss, Florence Kleberg, Andreas Knoblauch, Morten L. Kringelbach, Sol Lim, Paul Miller, Daniel Miner, Geoffrey G. Murphy, Mikaël Naveau, Steffen Platschek, Mark Plitt, Panayiota Poirazi, Ivan Raikov, Sebastian Rinke, James Roach, Fred Rothganger, Kurt A. Sailor, Leonard Sander, Vittorio Sanguineti, Mark Shaw, Quinton Skilling, Ivan Soltesz, Angus B.A. Stevner, Christian Tetzlaff, Gertraud Teuchert-Noodt, Jochen Triesch, Tim J. van Hartevelt, Arjen van Ooyen, Felix Wolf, Florentin Wörgötter, Karen Zito, Michal Zochowski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::571692cf3c7fb0005226e2b43af3e7c5
https://doi.org/10.1016/b978-0-12-803784-3.00034-2
https://doi.org/10.1016/b978-0-12-803784-3.00034-2
Autor:
Alison L. Althaus, Jack M. Parent
Publikováno v:
Endogenous Stem Cell-Based Brain Remodeling in Mammals ISBN: 9781489973986
Adult neurogenesis in the dentate gyrus is profoundly disrupted by seizure activity in experimental models. The relationship between this disruption, seizure-induced plasticity, and the pathogenesis of epilepsy is complex and not well understood, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017be13966fdcdadbe5c794447cbbf34
https://doi.org/10.1007/978-1-4899-7399-3_5
https://doi.org/10.1007/978-1-4899-7399-3_5