Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Alison L Tutt"'
Autor:
C Ian Mockridge, Kerry L Cox, Martin J Glennie, Mark S Cragg, Monika Semmrich, Linda Mårtensson, Ingrid Teige, Jordana Griffiths, Khiyam Hussain, Hannah L Smith, Theodore Sanders, Jinny Kim, Tatyana Inzhelevskaya, Chris A Penfold, Alison L Tutt, HT Claude Chan, Vikki English, Ruth F French, Bjorn L Frendeus, Jane E Willoughby
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Previous data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells which could evoke therapeutic responses. Human trials with anti-OX4
Externí odkaz:
https://doaj.org/article/86d9cb4f413b4935a92592aca78649b9
Autor:
Alexander P. Simpson, Ali Roghanian, Robert J. Oldham, H.T. Claude Chan, Christine A. Penfold, Hyung J. Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Yury D. Bogdanov, Sonya James, Alison L. Tutt, Daniel Rycroft, Peter Morley, Lekh N. Dahal, Ingrid Teige, Björn Frendeus, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Cell Reports. 40:111099
Many therapeutic antibodies deplete target cells and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are negatively regulated by the inhibitory FcγRIIB (CD32B). Dogma suggests inhibiti
Autor:
Claude H.T. Chan, Hannah L Smith, Theodore Sanders, Mark S. Cragg, Vikki English, Björn Frendéus, Martin J. Glennie, Ingrid Teige, Jordana Griffiths, Ruth R. French, Khiyam Hussain, Chris Penfold, Kerry L. Cox, Jane E. Willoughby, Tatyana Inzhelevskaya, Alison L. Tutt, Ian M Mockridge, Monika Semmrich, Jinny Kim, Aymen Al-Shamkhani, Linda Mårtensson
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundPrevious data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells which could evoke therapeutic responses. Human trials with anti-OX40
Autor:
Mei Cong, Maria J. Leandro, Patrick J. Duriez, Venkat Reddy, Brock Binkowski, Mark S. Cragg, H.T. Claude Chan, Robert J. Oldham, Geraldine Cambridge, Dun Li, Falk Nimmerjahn, Richard J. Stopforth, Philip G. Hargreaves, Alison L. Tutt, Anja Lux, Chad Zimprich
Publikováno v:
The Journal of Immunology. 200:1937-1950
Fc gamma receptors (FcγR) are involved in multiple aspects of immune cell regulation, are central to the success of monoclonal antibody (mAb) therapeutics and underpin the pathology of several autoimmune diseases. However, reliable assays capable of
Autor:
Anna H, Turaj, Kerry L, Cox, Christine A, Penfold, Ruth R, French, C Ian, Mockridge, Jane E, Willoughby, Alison L, Tutt, Jordana, Griffiths, Peter W M, Johnson, Martin J, Glennie, Ronald, Levy, Mark S, Cragg, Sean H, Lim
Publikováno v:
Scientific Reports
CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumou
Autor:
Christine A. Penfold, Mark S. Cragg, Betty Lau, H.T. Claude Chan, C. Ian Mockridge, Ali Roghanian, Emily L Williams, Alison L. Tutt, Kerry L. Cox, J. Sjef Verbeek, Ruth R. French, Martin J. Glennie
Publikováno v:
European Journal of Immunology. 42:2109-2120
Fc receptors (FcRs) play a key role in regulating and coordinating responses from both innate and adaptive arms of the immune system. The inhibitory Fc gamma receptor II (FcγRIIB; CD32) is central to this regulation with FcγRIIB−/− mice demonst
Autor:
Marjolein van Egmond, Marielle A. Otten, Jantine E. Bakema, Alison L. Tutt, Jan G. J. van de Winkel, Cornelis W. Tuk, Martin J. Glennie, R.H.J. Beelen
Publikováno v:
European Journal of Immunology. 42:1815-1821
Neutrophils potently kill tumour cells in the presence of anti-tumour antibodies in vitro. However, for in vivo targeting, the neutrophils need to extravasate from the circulation by passing through endothelial barriers. To study neutrophil migration
Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration
Autor:
Jessica L. Teeling, Martin J. Glennie, V. Hugh Perry, Katie Lunnon, Mark S. Cragg, Alison L. Tutt
Publikováno v:
The Journal of Immunology. 186:7215-7224
Chronic neurodegeneration is a major worldwide health problem, and it has been suggested that systemic inflammation can accelerate the onset and progression of clinical symptoms. A possible explanation is that systemic inflammation “switches” the
Publikováno v:
Journal of Immunological Methods. 363:1-8
As part of a Phase I chimeric anti-CD40 monoclonal antibody clinical trial, two enzyme-linked immunosorbent assays (ELISAs) were developed for secondary endpoints: 1) for the pharmacokinetic (PK) monitoring of serum antibody levels and 2) for immunog
Autor:
Hideo Yagita, Nathan A. Franklin, Alison L. Tutt, Drew J. Roberts, Lara M. Kingeter, Timothy N. J. Bullock, Martin J. Glennie
Publikováno v:
Journal of Immunotherapy. 33:769-779
The immune response to the tumor can be enhanced by targeting costimulatory molecules on T cells. As the CD70-CD27 costimulatory axis plays an important role in the activation, survival, and differentiation of lymphocytes, we have examined the effica