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pro vyhledávání: '"Alison K. Thomson"'
Autor:
Laura H Comley, Rachel A Kline, Alison K Thomson, Victoria Woschitz, Eric Villalón Landeros, Erkan Y Osman, Christian L Lorson, Lyndsay M Murray
Publikováno v:
Human Molecular Genetics. 31:3107-3119
Spinal muscular atrophy (SMA) is a childhood motor neuron disease caused by anomalies in the SMN1 gene. Although therapeutics have been approved for the treatment of SMA, there is a therapeutic time window, after which efficacy is reduced. Hallmarks
Publikováno v:
Cell Death and Disease, Vol 10, Iss 7, Pp 1-14 (2019)
Cell Death & Disease
Courtney, N L, Mole, A J, Thomson, A K & Murray, L M 2019, ' Reduced P53 levels ameliorate neuromuscular junction loss without affecting motor neuron pathology in a mouse model of spinal muscular atrophy ', Cell Death and Disease, vol. 10, 515 . https://doi.org/10.1038/s41419-019-1727-6
Cell Death & Disease
Courtney, N L, Mole, A J, Thomson, A K & Murray, L M 2019, ' Reduced P53 levels ameliorate neuromuscular junction loss without affecting motor neuron pathology in a mouse model of spinal muscular atrophy ', Cell Death and Disease, vol. 10, 515 . https://doi.org/10.1038/s41419-019-1727-6
Spinal Muscular Atrophy (SMA) is a childhood motor neuron disease caused by mutations or deletions within the SMN1 gene. At endstages of disease there is profound loss of motor neurons, loss of axons within ventral roots and defects at the neuromuscu
Autor:
Richard R. Ribchester, Lyndsay M. Murray, Sarah Bell, Alison K. Thomson, Alannah J. Mole, Kosala N. Dissanayake
Publikováno v:
Journal of Anatomy
Mole, A J, Bell, S, Thomson, A K, Dissanayake, K N, Ribchester, R R & Murray, L M 2020, ' Synaptic withdrawal following nerve injury is influenced by postnatal maturity, muscle-specific properties, and the presence of underlying pathology in mice ', Journal of Anatomy, vol. 237, no. 2, pp. 263-274 . https://doi.org/10.1111/joa.13187
Mole, A J, Bell, S, Thomson, A K, Dissanayake, K N, Ribchester, R R & Murray, L M 2020, ' Synaptic withdrawal following nerve injury is influenced by postnatal maturity, muscle-specific properties, and the presence of underlying pathology in mice ', Journal of Anatomy, vol. 237, no. 2, pp. 263-274 . https://doi.org/10.1111/joa.13187
Axonal and synaptic degeneration occur following nerve injury and during disease. Traumatic nerve injury results in rapid fragmentation of the distal axon and loss of synaptic terminals, in a process known as Wallerian degeneration (WD). Identifying
Autor:
Simon H. Parson, Hannah K. Shorrock, Thomas H. Gillingwater, Alison K. Thomson, Rachael A. Powis, Kathryn J. Swoboda, Eilidh Somers, Kelley J. Murphy
Publikováno v:
Thomson, A, Somers, E, Powis, R, Shorrock, H K, Murphy, K, Swoboda, K J, Gillingwater, T & Parson, S H 2016, ' Survival of motor neurone protein is required for normal postnatal development of the spleen ', Journal of Anatomy . https://doi.org/10.1111/joa.12546
Spinal muscular atrophy (SMA), traditionally described as a predominantly childhood form of motor neurone disease, is the leading genetic cause of infant mortality. Although motor neurones are undoubtedly the primary affected cell type, the severe in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2056ed27ed09345adeb468d6002f01
https://hdl.handle.net/20.500.11820/2e1a6a31-a480-4112-8139-fdadb62c2eba
https://hdl.handle.net/20.500.11820/2e1a6a31-a480-4112-8139-fdadb62c2eba