Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alison K. Hottes"'
Autor:
Hani Goodarzi, Bryson D Bennett, Sasan Amini, Marshall L Reaves, Alison K Hottes, Joshua D Rabinowitz, Saeed Tavazoie
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-12 (2010)
Abstract Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may
Externí odkaz:
https://doaj.org/article/638c5ed792a74e36a1c4c627d228ebc0
Autor:
Alison K Hottes, Peter L Freddolino, Anupama Khare, Zachary N Donnell, Julia C Liu, Saeed Tavazoie
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003617 (2013)
The metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each species' native ecological niche. In a new environment, however, the same bacteria may grow poorly due
Externí odkaz:
https://doaj.org/article/2ac6d6e037ea4a3495bbf6d2b1ad9d85
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002298 (2011)
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolera
Externí odkaz:
https://doaj.org/article/e1c5c86b9e40472f801bd85614809484
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5629 (2009)
BACKGROUND:Antibiotic exposure rapidly selects for more resistant bacterial strains, and both a drug's chemical structure and a bacterium's cellular network affect the types of mutations acquired. METHODOLOGY/PRINCIPAL FINDINGS:To better characterize
Externí odkaz:
https://doaj.org/article/38feb6d8ac8a42fdab7e63fc696b8dd0
National biodefense is a critical element of national security. Environmental biodetection and human biosurveillance are part of the foundation of national biodefense. This report examines the Department of Homeland Security's chemical and biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b68cff0b6d4a121ed971f57c5a26e5b
https://doi.org/10.7249/rr2398
https://doi.org/10.7249/rr2398
Publikováno v:
Molecular Cell. 35:247-253
Protein-DNA interactions are fundamental to core biological processes, including transcription, DNA replication, and chromosomal organization. We have developed in vivo protein occupancy display (IPOD), a technology that reveals protein occupancy acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb65fc98983555a14655c5cf0cc259c
https://doi.org/10.1016/j.molcel.2009.06.035
https://doi.org/10.1016/j.molcel.2009.06.035
Autor:
Patrick T. McGrath, Alison K. Hottes, Harley H. McAdams, Joseph C. Chen, Patrick H. Viollier, Lucy Shapiro
Publikováno v:
The EMBO Journal. 25:377-386
We demonstrate that successive cleavage events involving regulated intramembrane proteolysis (Rip) occur as a function of time during the Caulobacter cell cycle. The proteolytic substrate PodJ L is a polar factor that recruits proteins required for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366e0952f898aa80f26dbe0d49951964
https://doi.org/10.1038/sj.emboj.7600935
https://doi.org/10.1038/sj.emboj.7600935
Publikováno v:
Molecular Microbiology. 58:1340-1353
The level of DnaA, a key bacterial DNA replication initiation factor, increases during the Caulobacter swarmer-to-stalked transition just before the G1/S transition. We show that DnaA coordinates DNA replication initiation with cell cycle progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c737e7d042d7077c729340533fa9c06e
https://doi.org/10.1111/j.1365-2958.2005.04912.x
https://doi.org/10.1111/j.1365-2958.2005.04912.x
Publikováno v:
Nature methods
Nature methods, vol 6, iss 8
Nature methods, vol 6, iss 8
Although modern DNA sequencing enables rapid identification of genetic variation, characterizing the phenotypic consequences of individual mutations remains a labor-intensive task. Here we describe array-based discovery of adaptive mutations (ADAM),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e694f05bf41933df03af818736f454
https://doi.org/10.1038/nmeth.1352
https://doi.org/10.1038/nmeth.1352
Autor:
National Research Council, National Academy of Sciences, Division on Earth and Life Studies, Board on Life Sciences, Policy and Global Affairs, Committee on International Security and Arms Control, Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories, Fran Sharples, Benjamin Rusek, Alison K. Hottes
During July 10-13, 2011, 68 participants from 32 countries gathered in Istanbul, Turkey for a workshop organized by the United States National Research Council on Anticipating Biosecurity Challenges of the Global Expansion of High-containment Biologi